Product Name: Ketanserine tartrate
Chemical Formula: C22H22FN3O4 · C4H6O6
CAS Number: 63597-64-4
Synonyms: Ketanserin hydrogen tartrate
Recommended Use: Laboratory use, analytical reference, pharmaceutical research
Supplier: Manufacturer or distributor information listed on label
Emergency Contact: Refer to chemical supplier or national poison control center
GHS Classification: Acute Toxicity (Oral) Category 4, Eye Irritation Category 2A
Pictogram: Exclamation mark
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation
Precautionary Statements: Keep away from food/drink, wash hands after handling, avoid inhalation
Potential Health Effects: Inhalation or ingestion causes irritation, eye and skin contact brings risk of redness or pain, longer exposure elevates risk for serious health harm
Substance: Ketanserine tartrate
Chemical Name: 3-[2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl]quinazoline-2,4(1H,3H)-dione tartrate
CAS Number: 63597-64-4
Percent: >97% (purity may vary by supplier batch)
Impurities: Typically less than 2% by weight, consult certificate of analysis
Molecular Weight: 582.57 g/mol
Inhalation: Move person to fresh air, monitor for labored breathing, medical attention recommended for persistent symptoms
Skin Contact: Remove contaminated clothing, flush affected area with plenty of water and soap
Eye Contact: Rinse eyes with running water for several minutes, lift eyelids to ensure thorough rinsing, seek medical evaluation
Ingestion: Rinse mouth, never induce vomiting without instruction from medical professional, consult medical care for discomfort
Most Important Symptoms: Nausea, dizziness, irritation to airways or mucosa, intense discomfort in eyes or skin
Note to Physician: Treat symptomatically, monitor blood pressure, consider consultation with toxicologist
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical powder, carbon dioxide
Incompatible Extinguishing Media: Avoid direct jet of water, risk of spreading chemical
Hazards from Product: Combustion forms hazardous fumes, such as nitrogen oxides, carbon oxides, hydrogen fluoride and toxic organic vapors
Protective Equipment for Firefighters: Full protective suit, self-contained breathing apparatus
Advice for Firefighters: Move undamaged containers, prevent run-off to drains, keep upwind in firefighting scenario
Personal Precautions: Use gloves, lab coat, goggles, avoid breathing dust or vapors
Environmental Precautions: Prevent entry into drains, surface water, or soil
Cleanup Method: Scoop up with non-sparking tools, place into airtight containers for disposal, ventilate the area
Decontamination: Wash spill area with water and detergent, collect and dispose of cleaning media
Reference for Emergency Responders: Wear certified respiratory protection in enclosed space, isolate danger area
Safe Handling: Handle in well-ventilated area, avoid formation of dust, minimize exposure via handling aids
Hygiene: No eating, drinking, or smoking in use area, wash hands and forearms thoroughly after use
Storage Conditions: Store in tightly sealed container, cool and dry place away from heat, oxidizing agents or moisture
Storage Incompatibility: Keep away from strong bases, acids, oxidizers
Special Requirements: Use secondary containment for larger quantities, ensure containers are clearly labeled
Threshold Limit Value (TLV): Not established, handle as hazardous chemical
Engineering Controls: Use fume hood, local exhaust ventilation, eye-wash stations
Personal Protective Equipment (PPE): Chemical-resistant gloves, splash-proof goggles, lab coat, respiratory protection during dust formation
Environmental Exposure Controls: Prevent discharge to sewers, secure waste in sealed containers
Work Hygiene: Structural requirements for chemical work areas, shower and eyewash facilities nearby
Appearance: White to off-white crystalline powder
Odor: Odorless or faint odor
Odor Threshold: Not available
pH: Slightly acidic (aqueous solution)
Melting Point: 195–200 °C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not flammable by GHS classification
Solubility: Soluble in water, DMSO, ethanol
Vapor Pressure: Not determined
Vapor Density: Not determined
Relative Density: ~1.5 g/cm3
Partition Coefficient (logP): Not available
Decomposition Temperature: Above 200 °C
Chemical Stability: Stable under recommended storage conditions
Reactivity: No dangerous reactions expected under standard conditions
Incompatible Materials: Avoid strong oxidizing agents, acids, bases, moisture
Hazardous Decomposition Products: Releases nitrogen oxides, carbon oxides, hydrogen fluoride with heat or fire
Polymerization: Not known to polymerize
Acute Toxicity: Harmful if swallowed; oral LD50 in rodents ranges from 100 to 400 mg/kg (species-dependent)
Chronic Effects: Extended exposure linked to effects on blood pressure, central nervous system disorders
Routes of Exposure: Inhalation, ingestion, skin, eyes
Symptoms of Exposure: Irritation to eye, nose, throat, nausea, headache, possible hypertension or central nervous system depression
Carcinogenicity: No evidence from available data
Mutagenicity: No data indicate mutagenic effects
Reproductive Toxicity: Not sufficiently studied in humans
Sensitization: No data on sensitizing effect
Ecotoxicity: Harmful to aquatic organisms, limited data on long-term impacts
Persistence and Degradability: Not readily biodegradable in soil or aquatic environment
Bioaccumulation Potential: Data not available, but structurally possible for moderate accumulation in terrestrial or aquatic organisms
Mobility in Soil: Low mobility expected based on physical properties
Other Adverse Effects: No special hazards unless released in large quantities, potential to contaminate waterways with improper disposal
Waste Treatment Methods: Collect as hazardous waste in certified container
Disposal of Product: Use certified chemical incineration or hazardous waste landfill according to local, state, and national regulations
Disposal of Contaminated Packaging: Treat empty containers as hazardous, puncture and triple rinse if allowed, send for specialized waste processing
Environmental Precautions: Do not release to environment, prevent container breakage, always secure during transport
UN Number: Not classified as dangerous for transport
UN Proper Shipping Name: Not regulated
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions for User: Pack according to chemical safety guidance, keep sealed, prevent rupture or spillage during shipment, label visibly with chemical name, origin, and destination
Environmental Hazards: Not marine pollutant under GHS or IMDG
Transport in Bulk: Handle only in closed containers with spill containment measures
Safety, Health and Environmental Regulations: Subject to chemical safety rules by OSHA (USA), WHMIS (Canada), REACH (EU), and local national controls
Inventory Status: Listed or notified under TSCA (USA), EINECS/ELINCS (EU), AICS (Australia)
Labeling Requirements: GHS-compliant hazard and precautionary labels, include chemical name and handling pictograms
Specific legislation: Users required to review local, regional, and international regulations before commercial use or transfer
Restrictions: No restrictions for laboratory or analytical use but must comply with export/import permit rules or restrictions in pharmaceutical applications
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