Material Safety Data Sheet – Calcium Gluconate

Identification

Product Name: Calcium Gluconate
Chemical Formula: C12H22CaO14
CAS Number: 299-28-5
Synonyms: Calcium D-gluconate, Gluconic acid calcium salt
Recommended Use: Used in medicine for treating hypocalcemia, in food as a nutritional supplement
Supplier: Common pharmaceutical and chemical distribution companies
Contact Information for Emergency: National Poison Control Center, supplier-specific emergency lines

Hazard Identification

Classification: Not classified as hazardous under most GHS guidelines
Physical Hazards: May cause slight irritation to eyes, mild respiratory tract irritation in sensitive individuals
Label Elements: No universally required signal word, pictogram, or hazard statement
Hazard Statements: Prolonged exposure to dust may be irritating
Precautionary Statements: Use adequate ventilation, avoid unnecessary dust inhalation

Composition / Information on Ingredients

Chemical Name: Calcium Gluconate
Purity: Typically above 98% for pharmaceutical use
Impurities: Trace levels may include water, gluconic acid, other calcium salts
Component: Calcium Gluconate Single Substance
INCI: Calcium Gluconate
EINECS Number: 206-075-8

First Aid Measures

Inhalation: Move affected person to fresh air, seek medical attention if symptoms persist
Skin Contact: Wash thoroughly with mild soap and water, remove contaminated clothing
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lift eyelids occasionally
Ingestion: Rinse mouth, do not induce vomiting, seek medical advice especially for large exposures or symptoms
Most Important Symptoms: Mild eye, skin, or throat irritation possible

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Specific Hazards: Does not burn, may decompose at high temperatures to produce irritating fumes
Protective Equipment: Firefighters should wear standard protective gear and self-contained breathing apparatus
Advice: Avoid inhalation of combustion products, use water spray to cool containers

Accidental Release Measures

Personal Precautions: Avoid dust formation, ventilate area, use personal protective equipment
Environmental Precautions: Prevent further leakage or spillage if safe to do so, avoid discharge into drains
Containment and Cleaning: Sweep up and shovel, dispose of contents in a suitable container, wash spill area with water
Methods for Disposal: Place spilled material in approved waste container, flush residue with water

Handling and Storage

Handling: Handle in accordance with good industrial hygiene, avoid breathing dust, avoid contact with eyes
Storage: Store tightly closed in a cool, dry, well-ventilated area, protect from moisture and direct sunlight
Incompatible Materials: Strong oxidizing agents
General Hygiene: Wash hands after handling, keep away from food or beverages

Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific limit established for calcium gluconate, treat as nuisance dust (generally 10 mg/m³)
Engineering Controls: Ensure adequate ventilation, use local exhaust where dust is generated
Personal Protective Equipment: Safety glasses, gloves, dust mask in areas of high dust generation, lab coat
Hygiene Measures: Wash hands before eating, keep work clothing separate from other laundry

Physical and Chemical Properties

Appearance: White to almost white, crystalline powder or granules
Odor: Odorless
pH: Slightly acidic, around 6.0 – 8.0 for 10% solution
Solubility: Freely soluble in water, almost insoluble in ethanol
Melting Point: Decomposes before melting, above 200°C
Boiling Point: Not applicable (decomposes)
Density: Around 1.65 g/cm³
Molecular Weight: 430.37 g/mol
Flash Point: Not flammable
Vapor Pressure: Not applicable

Stability and Reactivity

Chemical Stability: Stable under normal conditions
Conditions to Avoid: Excessive heat, exposure to moisture
Incompatible Materials: Strong oxidizers
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, calcium oxides when decomposed at high temperatures
Polymerization: Will not occur under recommended handling and storage

Toxicological Information

Acute Toxicity: Low toxicity, oral LD50 in rats exceeds 5000 mg/kg
Chronic Effects: No known chronic toxicity when used properly
Skin Irritation: May cause mild irritation in sensitive persons
Eye Irritation: Dust can cause slight, transient eye irritation
Respiratory Sensitization: Inhalation of dust may lead to mild irritation
Mutagenicity / Carcinogenicity: Not classified as mutagenic or carcinogenic
Reproductive Toxicity: No reported effects on reproduction at therapeutic levels

Ecological Information

Aquatic Toxicity: No evidence of significant risk to aquatic life
Mobility in Soil: Highly soluble in water, may leach into ground if released in significant quantities
Bioaccumulative Potential: Does not accumulate in aquatic organisms
Persistence and Degradability: Readily biodegradable, breaks down to calcium and gluconic acid
Other Adverse Effects: Large spills can cause temporary imbalances in water hardness and mineral content

Disposal Considerations

Waste Disposal Methods: Dispose of in accordance with local, regional, and national regulations
Contaminated Packaging: Wash empty containers before final disposal or recycling
Special Precautions: Prevent residue from entering watercourses, avoid large uncontrolled releases
Regulatory Information: Not classified as a hazardous waste, but minimize environmental release

Transport Information

UN Number: Not regulated
UN Proper Shipping Name: Not dangerous for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not a marine pollutant
Special Precautions: Keep containers tightly closed during transport, protect from moisture

Regulatory Information

TSCA: Listed
DSL/NDSL (Canada): Listed
REACH (EU): Registered
OSHA Hazards: Not hazardous by OSHA criteria
WHMIS Classification: Non-controlled
FDA / Food Additive Status: GRAS (Generally Recognized As Safe) for intended food and medicinal uses
Other Regulations: Check specific country regulations for any restrictions or special labeling