Material Safety Data Sheet — Ethyl (R)-nipecotate L-tartrate

Identification

Product Name: Ethyl (R)-nipecotate L-tartrate
Synonyms: Ethyl (R)-nipecotate, L-tartaric acid salt
Chemical Formula: C10H17NO2 · C4H6O6
CAS Number: 1386147-20-7
Molecular Weight: 263.32 g/mol
Manufacturer: Details on request
Use: Intermediate in pharmaceutical synthesis, research applications
Recommended Restrictions: Laboratory and industrial use only
Emergency Phone: Provided by supplier or facility

Hazard Identification

GHS Classification: Not classified as hazardous under GHS guidelines in most jurisdictions
Hazard Statements: May cause mild skin and eye irritation; inhalation of dust can cause respiratory discomfort
Signal Word: Warning
Pictograms: Exclamation Mark
Precautionary Statements: Avoid breathing dust, wash skin thoroughly after handling, wear gloves, protect eyes and face
Potential Health Effects: Inhalation: coughing, shortness of breath; Skin: slight redness or dryness; Eyes: redness, watering; Ingestion: nausea, mild gastrointestinal distress
Aggravation of Pre-Existing Conditions: No known aggravations reported at standard laboratory exposures

Composition / Information On Ingredients

Chemical Identity: Ethyl (R)-nipecotate L-tartrate
Concentration: ≥98% (w/w)
Impurities: Water ≤0.5%, residual solvents ≤0.5%
Stabilizers: None present
Other Components: None

First Aid Measures

Inhalation: Remove person to fresh air, keep at rest, seek medical attention if symptoms persist
Skin Contact: Wash thoroughly with soap and water for several minutes, remove contaminated clothing
Eye Contact: Rinse gently with water for at least 15 minutes, lift eyelids occasionally, seek medical help if irritation persists
Ingestion: Rinse mouth without swallowing, drink small amount of water, get medical advice if feeling unwell
Acute Exposure Symptoms: Skin/eye redness, mild coughing, nausea
Note for Physicians: Treat symptomatically, consider observation for delayed allergic or irritant effects

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Media: Do not use strong water jet may cause product to spread
Fire Hazards: Combustion products may include carbon oxides, nitrogen oxides
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Special Precautions: Move containers from fire area if possible, cool exposed containers with water spray to prevent rupture
Specific Hazards: Fine dust in air could create explosion risk, ventilate area after fire

Accidental Release Measures

Personal Precautions: Avoid contact with skin and eyes, avoid inhalation of powder or dust, use respirator if needed
Protective Equipment: Gloves (nitrile or latex), goggles or face shield, lab coat
Environmental Precautions: Prevent product from entering drains, sewers, or natural waterways
Methods for Cleanup: Ventilate area, sweep or use HEPA-filtered vacuum to collect material into sealable plastic containers, avoid raising dust
Small Spills: Sweep up carefully, wipe affected area with damp cloth
Large Spills: Notify appropriate authorities, contain spill with dikes if needed, dispose according to regulations

Handling and Storage

Precautions for Safe Handling: Work in well-ventilated area, avoid dust generation, avoid contact with eyes and skin, wash hands after handling, do not eat or drink in workspace
Storage Conditions: Store in tight, light-resistant containers, keep out of reach of children, maintain between 2°C – 8°C in dry area
Incompatibilities: Strong acids, strong oxidizing agents, moisture
Specific End Use: Intended for pharmaceutical synthesis and specialized laboratory research only

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established OSHA/ACGIH limits for this compound
Engineering Controls: Use fume hood or local exhaust ventilation to minimize dust
Personal Protective Equipment: Splash goggles, chemical-resistant gloves, lab coat, respirator if airborne concentrations expected to exceed nuisance dust levels
Respiratory Protection: NIOSH-approved dust mask/P100 filter for dust and powder handling
Hand Protection: Chemical-resistant gloves (nitrile, latex)
Eye Protection: Tight-fitting safety goggles or face shield
Skin Protection: Long-sleeved clothing, closed shoes
Hygiene Measures: Wash hands after handling, remove contaminated clothing before break or leaving work area

Physical and Chemical Properties

Appearance: White or off-white crystalline powder
Odor: Odorless or faint organic odor
pH (5% solution): Neutral (6–7.5)
Melting Point: 142–148°C
Boiling Point: Not applicable (decomposes)
Solubility in Water: Moderately soluble
Solubility in Other Solvents: Soluble in ethanol, methanol; slightly soluble in acetone; insoluble in non-polar solvents
Density: 1.38 g/cm³
Vapor Pressure: Negligible at ambient temperature
Partition Coefficient (Kow): Not established
Flash Point: Not established
Explosive Properties: Not expected, dust may present risk if dispersed in air
Auto-Ignition Temperature: Not available

Stability and Reactivity

Chemical Stability: Stable under standard laboratory conditions
Thermal Decomposition: Decomposes at high temperatures, emits CO, CO2, NOx
Possibility of Hazardous Reactions: No hazardous polymerization reported
Incompatible Materials: Strong oxidizers, acids, bases, moisture
Conditions to Avoid: Heat, flames, sparks, direct sunlight, humid environment
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, possible organic vapors

Toxicological Information

Acute Toxicity: No toxicity data available for oral, dermal, or inhalation routes; structurally similar compounds show low acute toxicity
Skin Corrosion/Irritation: Mild irritation possible after prolonged or repeated exposure
Serious Eye Damage/Irritation: Slight irritation may occur
Respiratory Sensitization: Unlikely at standard exposure levels
Mutagenicity/Carcinogenicity: No data available suggesting mutagenic or carcinogenic potential
Reproductive Toxicity: No specific data; avoid unnecessary exposure during pregnancy
Other Effects: No reports of cumulative or chronic toxicity under normal handling conditions

Ecological Information

Ecotoxicity: No experimental data available; not expected to be acutely hazardous to aquatic organisms at standard laboratory concentrations
Persistence and Degradability: Estimated to be biodegradable, not persistent in environment
Bioaccumulation Potential: Low; structure implies little risk of bioaccumulation
Mobility in Soil: Expected moderate mobility if released to environment; avoid uncontrolled release
Other Adverse Effects: None known, but prevent direct entry into the environment

Disposal Considerations

Waste Treatment Methods: Dispose by incineration in accordance with local, state, and national regulations
Product Waste: Collect into a sealed, labeled, chemical waste container; incinerate with proper controls
Contaminated Packaging: Rinse containers, dispose as hazardous laboratory waste where required
Special Precautions: Do not wash down drains or natural waterways

Transport Information

UN Number: Not regulated under current UN criteria
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Use chemical-resistant packaging, label clearly, avoid exposure to moisture
Environmental Hazards: Not considered hazardous for transport under ADR, IATA, IMDG
Transport in Bulk: Not applicable

Regulatory Information

US Regulations: Not listed on the US TSCA Inventory for unrestricted use; for research purposes exempt
EU Regulations: Not listed under REACH Annex XVII; not classified as hazardous substance or mixture
Other Inventories: Not widely listed; consult country-specific requirements
Restrictions: For academic, industrial, or research use only; not for food, drug, or household uses
SDS Revision Date: As indicated by supplier