MSDS for Erythromycin, 6-O-methyl-, 4-O-beta-D-galactopyranosyl-D-gluconate (salt)

Identification

Product Name: Erythromycin, 6-O-methyl-, 4-O-beta-D-galactopyranosyl-D-gluconate (salt)
Synonyms: Erythromycin 6-O-methyl, Erythromycin derivative, Antibiotic salt
Chemical Family: Macrolide antibiotic derivative
Intended Use: Pharmaceutical ingredient, laboratory research
Supplier Information: Refer to company’s main point of contact for sourcing, product inquiries, and emergency numbers
Emergency Contact: For health or spill emergencies, reach out to poison control or local emergency services
Product Code: Specific to the manufacturer, not standardized
Recommended Use Restrictions: Not for food, domestic, or veterinary use unless specifically authorized
Physical Form: Powder or crystalline solid depending on supplier

Hazard Identification

GHS Classification: Skin sensitization (Category 1), Eye irritation (Category 2), Acute toxicity (Oral, Category 4)
Pictograms: Exclamation Mark
Signal Word: Warning
Hazard Statements: May cause an allergic skin reaction, harmful if swallowed, causes serious eye irritation
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, wear protective gloves/eye protection
Potential Health Effects: Eyes: Severe irritation, redness, tearing, blurred vision. Skin: Rash, redness, itching, possible eczema. Inhalation: Coughing, respiratory discomfort. Ingestion: Nausea, vomiting, abdominal cramps, diarrhea
Long-term Effects: Repeat exposure may trigger hypersensitivity reactions
Environmental Hazards: Harmful to aquatic organisms, avoid release to environment

Composition / Information on Ingredients

Chemical Name: Erythromycin, 6-O-methyl-, 4-O-beta-D-galactopyranosyl-D-gluconate
CAS Number: Supplier-specific, verify with batch sheet
Concentration: Active content above 90% by weight, balance includes trace salts and excipients depending on the form
Impurities: Minimal, generally controlled by good manufacturing practice standards
Other Components: Residual solvent and hydration water are possible in minor traces

First Aid Measures

Eye Contact: Rinse immediately with plenty of clean, lukewarm water for at least 15 minutes, holding eyelids apart, seek medical help without delay
Skin Contact: Wash with soap and copious amounts of water, remove contaminated clothing, if signs of irritation or allergy appear, consult a doctor
Inhalation: Move person to fresh air, keep them at rest, provide oxygen if breathing is difficult, get immediate medical attention for persistent symptoms
Ingestion: Rinse mouth, do not induce vomiting, never give anything by mouth to an unconscious person, contact poison control and medical professionals
Notes to Physician: Treat symptomatically, monitor for possible allergic or hypersensitivity reaction, supportive therapy as required

Fire-Fighting Measures

Extinguishing Media: Use dry chemical, CO2, or water foam as suitable for surrounding materials. Avoid direct water jet on product
Specific Hazards: Products of combustion include carbon monoxide, carbon dioxide, nitrogen oxides, and unidentified organic compounds
Protective Equipment: Full protective gear, self-contained breathing apparatus required for firefighting
Fire Hazards: Fine dust dispersed in air can form explosive mixtures; avoid creating dust clouds
Special Procedures: Move intact containers away from the fire area if safe to do so. Cool exposed containers with spray. Do not flush product into drains or natural waterways

Accidental Release Measures

Personal Protection: Suitable PPE including gloves, lab coat, goggles, NIOSH-approved respirator if dust likely
Environmental Protection: Prevent spillage from entering drains, watercourses, or soil
Cleanup Method: Collect spilled powder using non-sparking tools, minimize dust, place into a secure, labeled container for proper disposal
Decontamination: Wipe low-level residues with damp cloth or absorbent, followed by safe disposal
Local Regulations: Dispose of according to regional, national, or local regulations

Handling and Storage

Handling Precautions: Keep container tightly sealed after opening, avoid generating dust, wash hands before breaks and after work, avoid contact with skin, eyes, clothing
Storage Requirements: Store in a dry, cool, well-ventilated place, protect from light and moisture
Incompatible Materials: Strong acids, strong bases, oxidizing agents
Storage Container: Use original, properly labeled, corrosion-resistant containers
Specific End Use: Only qualified personnel should handle in pharmaceutical or laboratory environments

Exposure Controls and Personal Protection

Engineering Controls: Use in well-ventilated area with local exhaust where dust is possible, enclose process where feasible
Personal Protective Equipment (PPE): Chemical-resistant gloves, safety goggles, lab coat, dust mask or respirator if airborne particles possible
Hygiene Measures: No eating or drinking in exposure area, wash thoroughly after handling
Exposure Limits: No established OSHA, ACGIH, or NIOSH exposure limits, but avoid exposure as much as possible in line with good laboratory practices
Environmental Controls: Prevent product from reaching water or soil through effective containment

Physical and Chemical Properties

Appearance: White to off-white powder or crystalline solid
Odor: Faint, medicinal
Odor Threshold: Not established
pH: 7.0–9.0 (5% solution)
Melting Point: Decomposes above 140 °C
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Combustible as dust
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Solubility in Water: Freely soluble
Partition Coefficient: Not available
Auto-ignition Temperature: Not established
Decomposition Temperature: Around 140 °C
Viscosity: Not available

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No hazardous reactivity under normal processing
Conditions to Avoid: Prolonged heating, moisture, light exposure, and incompatible substances
Incompatible Materials: Strong oxidizing agents, strong acids, bases
Hazardous Decomposition Products: Releases carbon oxides, nitrogen oxides, and unidentified organic compounds on decomposition
Polymerization: Will not occur under normal storage

Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Gastrointestinal upset, allergic skin reactions, mild respiratory distress on large exposures
Chronic Toxicity: Sensitization possible with repeat or long-term exposure, especially skin
Carcinogenicity: No data indicates carcinogenic risk in humans
Mutagenicity: Not known to be mutagenic
Reproductive Effects: No definitive studies, caution recommended for women of childbearing age
Sensitization: Confirmed risk for allergic reactions in susceptible individuals
LD50 (Oral, Rat): Specific value unavailable, expected moderate toxicity

Ecological Information

Ecotoxicity: Toxic to aquatic life with possible long-term adverse effects
Persistence and Degradability: Moderately persistent, not rapidly biodegradable
Bioaccumulative Potential: Limited data, likely low due to water solubility
Mobility in Soil: Moderate, may leach to surface water if released in quantity
Other Environmental Effects: Antibiotic properties pose ecological disruption risks to microbial communities
Water Hazard Classification: May require specialized disposal to avoid waterway contamination

Disposal Considerations

Waste Disposal: Treat as pharmaceutical waste, incinerate in approved facility where permitted, avoid landfill or sewer disposal
Contaminated Packaging: Dispose with same precautions as unused product, do not reuse containers
Disposal Precautions: Minimize dust during transfer and handling, comply with local waste regulations
Community Impact: Never flush down household drains; professional chemical disposal recommended

Transport Information

UN Number: Not regulated for ground or sea transport
Proper Shipping Name: Not hazardous as defined by transport authorities
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Labeling Requirements: Standard product labeling for identification, include toxic pictogram if available
Special Precautions: Protect containers from physical damage, moisture, and sunlight during transit

Regulatory Information

OSHA Status: Not specifically listed as hazardous, general chemical hygiene applies
TSCA Status: Not listed as a commercial chemical
EU Regulation: Not subject to REACH registration as medicinal product
WHMIS Classification (Canada): Pharmaceutical, not generally classified under workplace hazards
Other Regulations: Must comply with applicable national regulations on waste, water protection, and pharmaceutical handling; observe prescription drug regulations where applicable
Workplace Exposure Control: No threshold limit value assigned; local risk management standard should guide PPE and administrative controls
Product Labeling: Detailed batch and traceability information required per current GMP for pharmaceutical components