Material Safety Data Sheet – Epinephrine Hydrogen Tartrate

Identification

Product Name: Epinephrine Hydrogen Tartrate
Chemical Formula: C9H13NO3·C4H6O6
Synonyms: Adrenaline Tartrate, Epinephrinum Hydrogen Tartrate
CAS Number: 51-42-3
Recommended Use: Pharmaceutical, laboratory use
Supplier Contact: Emergency response numbers and responsible company details listed on shipping documentation or chemical label according to local regulations

Hazard Identification

GHS Classification: Acute toxicity (oral), Skin irritation, Eye irritation, Respiratory system effects
Label Elements: Signal word: Danger; Hazard pictograms include skull and crossbones, exclamation mark
Hazard Statements: Toxic if swallowed, Causes skin and eye irritation, May cause allergic skin reaction, May cause respiratory distress, May cause central nervous system effects
Precautionary Statements: Avoid breathing dust, Do not ingest, Wear protective clothing, Wash hands thoroughly after handling, Avoid contact with skin, eyes, and clothing

Composition / Information on Ingredients

Chemical Name: Epinephrine hydrogen tartrate
Concentration: 98-100%
Other Components: No significant impurities affecting classification
Molecular Weight: 333.3 g/mol

First Aid Measures

Inhalation: Move the exposed individual to fresh air, keep at rest, seek immediate medical attention for breathing difficulty or irritation
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water and soap, consult a physician if symptoms develop
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing, call for medical attention
Ingestion: Immediately call a poison center or doctor, rinse mouth with water, do not induce vomiting without medical advice
Most Important Symptoms: Tachycardia, hypertension, anxiety, sweating, palpitations, nausea, possible allergic reactions

Fire-Fighting Measures

Extinguishing Media: Use water spray, foam, dry powder, or carbon dioxide
Special Hazards: Emits toxic fumes (carbon oxides, nitrogen oxides) on combustion
Protective Equipment: Wear full protective gear including self-contained breathing apparatus
Specific Procedures: Remove containers from fire area if safe, keep containers cool with water spray to prevent rupture

Accidental Release Measures

Personal Precautions: Use personal protective equipment, avoid generating dust, ensure adequate ventilation
Environmental Precautions: Prevent further leakage, do not let product enter drains or watercourses
Cleanup Procedures: Sweep up carefully, avoid dust formation, collect in suitable containers for disposal, wash contaminated area with water, ventilate area after cleanup

Handling and Storage

Safe Handling Guidelines: Avoid contact with skin, eyes, clothing, minimize dust generation, use with local exhaust ventilation, wash hands after handling
Storage Conditions: Store in a tightly sealed container, keep in a cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers and acids, protect from light, store below room temperature but not freezing

Exposure Controls and Personal Protection

Exposure Limits: No established occupational exposure limits, limit exposure as low as reasonably achievable
Engineering Controls: Use fume hood or local exhaust
Eye Protection: Wear safety glasses with side shields or chemical goggles
Skin Protection: Use chemical-resistant gloves, lab coat or apron
Respiratory Protection: Use NIOSH-approved respirator if dust or aerosols are generated
General Hygiene: Do not eat, drink, or smoke while handling the product, remove contaminated clothing before leaving the work area

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Odorless or faint
Melting Point: 150–155°C (decomposition)
Solubility: Soluble in water, slightly soluble in ethanol
pH (1% solution): 3.0–5.0
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Not significant at room temperature
Flash Point: Not applicable
Partition Coefficient: Log Pow -1.3 (estimated)

Stability and Reactivity

Chemical Stability: Stable if stored properly away from light and moisture
Conditions to Avoid: Excess heat, light, moisture, strong acids, oxidizing agents
Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, tar and irritating fumes
Hazardous Polymerization: Will not occur

Toxicological Information

Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity (Oral): LD50 (rat): 3 mg/kg (as base)
Health Effects: Increased heart rate, hypertension, tremor, insomnia, anxiety, restlessness, possible allergic reactions
Chronic Exposure: May affect cardiovascular and nervous systems with repeated exposure
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity & Reproductive Effects: No data suggesting mutagenic or reproductive hazards in humans at occupational exposures

Ecological Information

Aquatic Toxicity: Data limited, not expected to be highly toxic to aquatic life but may cause local effects
Persistence and Degradability: Expected to biodegrade over time
Bioaccumulation: Low potential for bioaccumulation
Mobility in Soil: Likely mobile if released due to water solubility
Other Effects: Chemical can disrupt local microorganism populations if released in large quantities, follow proper disposal guidance to avoid environmental contamination

Disposal Considerations

Waste Disposal Methods: Dispose of contents in accordance with local, regional, and national regulations
Packaging: Rinse containers thoroughly before disposal, dispose of as hazardous waste
Precautions for Disposal: Do not release to the environment, use sealed, labeled containers for collection

Transport Information

UN Number: 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (Epinephrine hydrogen tartrate)
Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Environmental Hazard: Not classified as marine pollutant
Special Precautions: Transport in secure containers, protect from physical damage and moisture

Regulatory Information

OSHA: Hazardous chemical under OSHA Hazard Communication Standard
TSCA Status: Listed or exempt
EINECS/ELINCS: Listed
EU Classification: Toxic (T), Irritant (Xi)
DSL/NDSL (Canada): Listed
SARA/Title III: Not subject to reporting under Sections 302, 304, 313
California Proposition 65: Not listed as a carcinogen or reproductive toxin