Product Name: DL-Phenylpropanolamine Hydrochloride
Chemical Formula: C9H13NO·HCl
CAS Number: 51-12-7
EC Number: 200-085-6
Manufacturers: Pharmaceutical and chemical suppliers worldwide
Synonyms: α-(1-Aminoethyl)benzyl alcohol hydrochloride, PPA·HCl
Intended Use: Pharmaceutical manufacturing, laboratory research
Recommended Restrictions: Not intended for food, cosmetic, or household applications
Classification: Acute Toxicity (Oral), Eye Irritation, Specific Target Organ Toxicity
GHS Labels: Warning, exclamation mark
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause drowsiness or dizziness
Potential Health Effects: Inhalation can irritate airways, contact causes redness in eyes and skin, ingestion may upset digestive system, large doses cause cardiovascular and neurological effects
Environmental Hazard: Not classified as environmentally hazardous, but care needed to avoid contamination
Other Risks: May pose additional hazards as a precursor in regulated drug synthesis
Main Component: DL-Phenylpropanolamine Hydrochloride
Percentage: >99% pure substance
Impurities: Residual organic solvents from synthesis, not typically exceeding 0.1%
Stabilizers or Additives: None
Excipients/Fillers: None
Inhalation: Move exposed individual into fresh air, provide oxygen if breathing is difficult, seek medical attention for persistent symptoms
Eye Contact: Wash thoroughly with running water for at least 15 minutes, lift eyelids to ensure thorough rinsing, seek immediate advice if irritation remains
Skin Contact: Remove contaminated clothing, wash skin with plenty of soap and water, get medical help if irritation occurs
Ingestion: Rinse mouth thoroughly, do not induce vomiting, provide water to dilute if victim is conscious, medical attention advised due to possible cardiovascular effects
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, alcohol-resistant foam
Specific Hazards: Product decomposes at high temperature producing potentially toxic fumes (nitrogen oxides, hydrochloric acid, carbon monoxide)
Protective Equipment: Full protective gear, self-contained breathing apparatus
Advice for Firefighters: Approach from upwind to avoid hazardous vapors, keep containers cool with water spray if exposed to fire, prevent runoff to drains or water bodies
Personal Precautions: Avoid inhalation of dust, avoid direct contact with skin and eyes, wear gloves and goggles
Spill Response: Ventilate the area, prevent entry of spill into drains or watercourses, collect material using non-sparking tools, transfer to a secure, labeled waste container
Clean-Up Methods: Wash contaminated area with water and detergent after removal, dispose in compliance with local regulations
Environmental Precautions: Prevent contamination of soil, water, and sewers by containing and collecting material promptly
Handling: Work in a ventilated area, prevent dust formation, avoid breathing dust, avoid contact with skin, eyes, or clothing, wash hands after use, keep away from incompatible substances (strong oxidizers, acids)
Storage: Store in tightly closed container, in a cool, dry, and well-ventilated place, away from sunlight and heat sources, maintain temperature below 30°C, segregate from food and strong chemicals, secure storage from unauthorized access
Occupational Exposure Limits: No established limits, handle with care as if exposure limits exist
Engineering Controls: Use local exhaust ventilation, fume hood, or other engineering controls to keep airborne levels low
Personal Protective Equipment: Safety goggles, gloves (nitrile or neoprene), laboratory coat, dust respirator if powder is handled in bulk
Hygiene Measures: Wash hands before breaks and at end of work, keep work space clean, do not eat or drink in work area
Environmental Controls: Prevent release to wastewater and outside environment, use spill containment measures
Appearance: White to off-white crystalline powder
Odor: Slight, characteristic odor
Melting Point: 188–190°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, slightly soluble in alcohol, insoluble in ether
pH (1% solution): 4–6
Vapor Pressure: Negligible at room temperature
Relative Density: 1.2–1.3 g/cm³
Partition Coefficient (log Kow): Not determined
Flashpoint: Not applicable for solids
Autoignition Temperature: Not available
Chemical Stability: Stable under normal temperatures and pressures, degrades on prolonged heating
Reactivity: Reacts vigorously with strong oxidizing agents, reducing agents, strong acids
Conditions to Avoid: Moisture, prolonged exposure to light, excessive heat
Incompatible Materials: Oxidizers (peroxides, nitrates), acids, alkalis
Decomposition Products: Nitrogen oxides, hydrogen chloride, carbon monoxide, carbon dioxide
Acute Toxicity: Oral LD50 (rat): 1,300 mg/kg; symptoms can include headache, palpitations, tremors, hypertension
Skin Irritation: May cause mild irritation on prolonged exposure
Eye Irritation: Produces redness, pain, and tearing
Chronic Effects: Repeated or prolonged exposure can affect blood pressure, nervous system
Sensitization: Not reported in routine chemical handling
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Mutagenicity/Teratogenicity: Data limited, not classified for these effects
Additional Risks: Possible interaction with medications such as monoamine oxidase inhibitors
Eco-Toxicity: May pose slight risk to aquatic life due to acute toxicity in high concentrations
Persistence and Degradability: Pyridine ring structure degrades slowly in environment
Bioaccumulation Potential: Not expected due to moderate water solubility
Mobility in Soil: Expected to be mobile in moist soils due to solubility
Other Adverse Effects: Avoid disposal to the environment, do not release untreated material to sewers or surface waters
Waste Treatment Methods: Dispose through licensed chemical waste contractor
Disposal of Product: Place in labeled, sealed container, dispose of in compliance with local, regional, national regulations
Contaminated Packaging: Rinse with copious water, then dispose as chemical waste
Recycling: Not suitable for recycling due to pharmaceutical restrictions
Avoidance: Do not discharge to natural waters, public sewers, or soil
UN Number: Not classified as hazardous for transport
Proper Shipping Name: Chemical, non-hazardous
Transport Hazard Class: N/A
Packing Group: N/A
Special Precautions: Keep upright, avoid release during transport, keep away from incompatible substances, transport in secure containers
Additional Information: For bulk shipments, ensure compliance with all customs and substance control regulations
U.S. Regulations: Listed on TSCA inventory, subject to DEA notice due to precursor status, SARA and CERCLA reporting not required
European Union Regulations: Listed under REACH inventory, substance-of-interest in narcotics control, requires compliance with national chemical safety protocols
Asia-Pacific Regulations: Listed in key national chemical inventories (China IECSC, Japan ENCS, Korea ECL)
Label Requirements: GHS-compliant labeling in all jurisdictions, warning statements for toxicological and environmental risks
Worker Registration: Required for high-risk applications, restricted to authorized personnel in some regions
National Legislation: Follows specific country requirements regarding therapeutic, precursor, or environmental control
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