Product Name: dl-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
Synonyms: Propranolol hydrochloride (racemic)
CAS Number: 318-98-9
Recommended Use: Pharmaceutical intermediate and research chemical
Supplier: Manufacturer details available upon request; refer to specific procurement records for supplier addresses.
Emergency Contact: Chemtrec 1-800-424-9300 (USA); for regions outside, refer to local poison control.
Classification: Acute toxicity (oral, dermal, inhalation), specific target organ toxicity (single exposure), irritant (eyes, skin, respiratory)
Label Elements: Danger signal word; skull and crossbones pictogram; exclamation mark
Hazard Statements: Toxic if swallowed, in contact with skin, or if inhaled. Causes serious eye irritation. May cause drowsiness or dizziness.
Precautionary Statements: Avoid breathing dust or vapors. Wash thoroughly after handling. Store locked up, only use with adequate ventilation. Wear protective gloves, eye and face protection.
Chemical Name: dl-1-(isopropylamino)-3-(1-naphthyloxy)-2-propanol hydrochloride
Synonyms: Propranolol hydrochloride (racemic)
Molecular Formula: C16H21NO2•HCl
Molecular Weight: 295.80 g/mol
Concentration: ≥ 98%
Impurities: Trace solvents & byproducts may be present & should be verified by the manufacturer’s batch testing records.
Inhalation: Move affected person outdoors to fresh air immediately. Seek medical attention if symptoms of respiratory distress, dizziness, or unconsciousness occur.
Skin Contact: Rinse area with generous amounts of water and remove contaminated clothing. Wash with soap and water for a minimum of 15 minutes. Seek medical attention if irritation or signs of toxicity appear.
Eye Contact: Flush eyes with running water for at least 15 minutes, holding eyelids open. Do not allow victim to rub eyes. Get medical attention, especially if redness, pain, or visual disturbance persists.
Ingestion: Do not induce vomiting unless instructed by a medical professional. Rinse mouth with water. Never give anything by mouth to an unconscious person. Call a poison center or doctor immediately.
Important Symptoms: May cause cardiovascular, nervous system, or respiratory effects. Drowsiness, slow heartbeat, shortness of breath, skin or eye irritation are possible.
Advice for Doctors: Treat symptomatically and provide supportive care. Monitor blood pressure, heart and respiratory function. Activated charcoal may reduce absorption.
Suitable Extinguishing Media: Use carbon dioxide, foam, dry chemical powder, or water spray.
Unsuitable Extinguishing Media: Direct water jets can disperse powders and increase risk of exposure.
Specific Hazards: Thermal decomposition generates toxic gases including nitrogen oxides, hydrochloric acid vapors, carbon monoxide, and carbon dioxide.
Advice for Firefighters: Wear self-contained breathing apparatus and full protective suit. Isolate incident scene and keep unauthorized personnel away.
Explosion Data: Powder can potentially form combustible dust clouds in air, risk of explosion exists under certain conditions.
Personal Precautions: Evacuate unnecessary people from area. Avoid breathing powders or vapors. Use respirator, chemical safety goggles, gloves, and protective clothing.
Environmental Precautions: Prevent further leakage or spillage if safe. Do not let chemical enter drain, water systems, or soil.
Cleanup Methods: Damp down powders to minimize dust. Sweep up and place into suitable containers for disposal. After initial clean-up, wash contaminated area with soap and water.
Decontamination: Properly dispose all materials used to clean the spill. Ventilate area and prevent accumulation of dust.
Handling: Avoid contact with skin, eyes, and clothing. Do not breathe dust or vapors. Use in fume hood or well-ventilated area. Avoid sources of ignition.
Hygiene: Wash hands thoroughly after handling. Remove contaminated clothing; launder before reuse. Do not eat, drink, or smoke while working.
Storage: Store in tightly closed, labeled containers away from moisture, heat, and incompatible substances such as oxidizers and strong acids or bases. Keep locked and in a cool, dry, well-ventilated area dedicated to hazardous materials.
Storage Temperature: Ambient, but avoid extremes of temperature.
Control Parameters: No established OSHA, NIOSH, or ACGIH exposure limits for this compound; use as low as reasonably achievable (ALARA) principle.
Engineering Controls: Use process enclosures, local exhaust ventilation, and other engineering controls to keep airborne levels below recommended exposure limits.
Personal Protective Equipment: Nitrile or rubber gloves, standard laboratory goggles, and lab coat. For bulk handling or cleaning spills, use NIOSH-approved respirator and chemical splash suit.
Environmental Controls: Prevent material from entering water systems or soil. Use containment where possible.
Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical odor
Boiling Point: Data not available; decomposes before boiling
Melting Point: 163-166 °C (hydrochloride salt)
Solubility: Soluble in water and methanol; sparingly soluble in ethanol; insoluble in most organic solvents
Vapor Pressure: Negligible at room temperature
Density: Not established (typical solid densities apply)
pH: Slightly acidic in solution
Partition Coefficient (log Pow): Approximately 1.5
Chemical Stability: Stable under normal laboratory and storage conditions (sealed, dry, cool).
Reactivity: Avoid strong oxidizers, acids, and bases that may lead to decomposition.
Decomposition Products: Releases toxic gases such as NOx, CO, CO2, and HCl on combustion or in contact with incompatible substances.
Polymerization: No data suggesting hazardous polymerization under expected conditions.
Incompatibility: Avoid finely divided metals, peroxides, oxidizing agents, and alkali metals.
Acute Toxicity: Oral LD50 (rat): 331 mg/kg (as propranolol HCl); inhalation and dermal toxicity significant based on structure and class information.
Skin Irritation: May cause moderate skin irritation; prolonged contact increases effect.
Eye Irritation: Risk of serious eye irritation and possible corneal injury.
Chronic Effects: Risk of cumulative effects due to systemic absorption; possible cardiovascular or CNS effects.
Sensitization: No known evidence, but caution warranted for individuals with history of drug allergies.
Carcinogenicity, Mutagenicity, Reproductive Effects: Not listed by IARC, NTP, OSHA as carcinogenic; limited evidence of reproductive or mutagenic effects in animal studies for related compounds.
Target Organ Effects: Heart, central nervous system, liver.
Ecotoxicity: May be toxic to aquatic life with long lasting effects; beta-blockers and related compounds have shown adverse effects at low concentrations in laboratories.
Persistence and Degradability: Partial biodegradability; breakdown may take place over weeks to months in natural environments.
Bioaccumulation Potential: Low to moderate; has been detected in surface waters impacted by pharmaceutical waste.
Mobility in Soil: Expected to have moderate mobility; avoid discharge to terrestrial or aquatic environments.
Other Adverse Effects: No specific data on ozone layer depletion, indirect photo-oxidative effects are possible but not well documented.
Waste Disposal: Dispose of in accordance with local, regional, and national regulations. Incineration in a chemical incinerator equipped with afterburner and scrubber preferred for large quantities.
Container Disposal: Rinse containers with solvents compatible with waste handling facility instructions before discarding.
Precautions: Do not dispose of into sewer, natural waterways, or general solid waste stream.
Unused Product: Return to authorized waste handler or disposal contractor trained for cytotoxic or hazardous drugs.
UN Number: Not assigned (consult with shipping provider for most current number according to local regulations).
Proper Shipping Name: Pharmaceutical intermediate, toxic, n.o.s.
Hazard Class: 6.1 (Toxic Substance)
Packing Group: III (Moderate hazard)
Labeling Requirements: Toxic substance labeling required; comply with International Air Transport Association (IATA), International Maritime Dangerous Goods (IMDG), and Department of Transportation (DOT) standards.
Special Precautions: Avoid transport with foodstuffs, animal feed, or oxidizing materials. Ensure secure packaging and proper documentation.
Regulatory Status: Not listed as a controlled substance, but subject to chemical safety regulations in many regions.
OSHA Status: Hazardous chemical as defined by Hazard Communication Standard (29 CFR 1910.1200).
TSCA Status: Substance may require reporting under Toxic Substances Control Act.
ECHA/REACH Status: Registration or authorization may be required within the European Union if quantity thresholds are met.
WHMIS (Canada): Class D2B - Toxic material.
Other International Listings: Specific country-level regulation may apply for import, use and disposal.
Risk Phrases: R25 (Toxic if swallowed), R22 (Harmful if swallowed), R36/37/38 (Irritating to eyes, respiratory system, and skin).
Safety Phrases: S1/2 (Keep locked up and out of reach of children), S28 (After contact with skin, wash immediately with plenty of water), S36/37/39 (Wear suitable protective clothing, gloves, and eye/face protection).
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