Material Safety Data Sheet: Di-o-toluoyl-D-tartaric acid

Identification

Product Name: Di-o-toluoyl-D-tartaric acid
Chemical Formula: C18H16O8
CAS Number: 32634-68-7
Synonyms: 2,3-Dihydroxy-1,4-bis(o-toluoyl)-D-tartaric acid
Supplier: Manufacturer or distributor contact details must appear on product labeling
Recommended Use: Chiral resolving agent in chemical laboratories and pharmaceutical synthesis
Emergency Contact: Local poison control center or emergency response number listed on product packaging

Hazard Identification

GHS Classification: Not classified as hazardous based on available data, but dust can cause minor irritation
Signal Word: None required
Hazard Statements: Prolonged or repeated exposure can cause mild skin and eye irritation; inhalation of dusts may irritate respiratory tract
Precautionary Statements: Avoid inhalation, contact with skin and eyes; use good laboratory hygiene; handle with protective gear
Potential Health Effects: Eyes—Redness, tearing, itching. Skin—Dryness or mild rash in sensitive individuals. Inhalation—Cough, throat irritation. Ingestion—Nausea or gastrointestinal upset if large quantities are swallowed

Composition / Information on Ingredients

Chemical Name: Di-o-toluoyl-D-tartaric acid
Percentage: >98% pure
Impurities: Trace organic residues from manufacturing, not anticipated to present additional hazard
Molecular Weight: 360.32 g/mol
Contaminants: None typically present at significant levels

First Aid Measures

Eye Contact: Flush continuously with plenty of water for up to 15 minutes; seek medical advice if symptoms persist
Skin Contact: Remove contaminated clothing, wash affected area with soap and water; seek medical attention for irritation
Inhalation: Remove to fresh air, support breathing as needed; medical assistance if respiratory symptoms occur
Ingestion: Rinse mouth thoroughly, drink water to dilute, seek medical attention if feeling unwell or if large amount is ingested
Self-Protection: Use disposable gloves and safety goggles during handling; always wash hands after exposure
Notes to Physician: Treat based on symptoms; no specific antidote available

Fire-Fighting Measures

Extinguishing Media: Use carbon dioxide, dry chemical, or foam for small fires; water spray for larger scenarios, but avoid direct stream
Special Hazards: Combustion can generate carbon oxides and irritating fumes; no unusual explosion risk
Fire Fighting Instructions: Firefighters should wear self-contained breathing apparatus and full protective clothing
Thermal Decomposition: Releases carbon monoxide, carbon dioxide, benzoic acid vapors

Accidental Release Measures

Personal Precautions: Wear gloves, goggles, and lab coat or apron; avoid breathing dust; restrict access to area
Cleanup Methods: Sweep up spillage using non-sparking tools and collect for proper disposal; ventilate area
Environmental Precautions: Prevent powder from getting into drains or water systems; sweep carefully to minimize powder in air
Decontamination: Rinse residue with water, collect washings for authorized chemical waste disposal
Disposal: Place collected solid in sealed labeled containers for disposal as hazardous waste

Handling and Storage

Precautions for Safe Handling: Avoid generating dust; handle inside well-ventilated hood or with extraction; use protective gloves and eyewear
Storage Conditions: Store in tightly sealed container in dry, cool place, away from direct sunlight or heat sources
Incompatible Materials: Strong bases, strong oxidizing agents
Segregation: Store away from food, beverage, and incompatible chemicals
Recommended Packaging: Keep in original packaging or compatible secondary containment labeled for laboratory chemicals

Exposure Controls and Personal Protection

Engineering Controls: Provide local exhaust or full enclosure to minimize airborne dust; standard laboratory ventilation systems
Personal Protection: Wear chemical-resistant gloves (nitrile or neoprene), safety goggles or glasses with side shields, disposable lab coat
Respiratory Protection: Dust mask or particulate respirator if dust generation is expected
Hygiene: Wash hands before breaks and after handling; launder contaminated clothing before reuse
Exposure Limits: No established occupational limits; avoidance of unnecessary exposure advised

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Faint, not distinctive
Odor Threshold: Not available
pH: Slightly acidic in water solution
Melting Point: 168–170°C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water; readily soluble in alcohol, acetone, and other organic solvents
Density: Approximately 1.51 g/cm³
Flash Point: Data not available; not expected to be highly flammable
Vapor Pressure: Not relevant (solid at standard conditions)
Partition Coefficient (log Kow): Not determined
Autoignition Temperature: Not established
Explosive Properties: No evidence of explosive properties under typical lab conditions

Stability and Reactivity

Chemical Stability: Stable at room temperature in dry, closed containers
Conditions to Avoid: Excess heat, moisture, dust generation
Incompatible Substances: Strong oxidizers, strong bases can degrade material or cause hazardous reactions
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, various organic acids
Polymerization: No hazardous polymerization reported

Toxicological Information

Acute Toxicity: Not classified as acutely toxic; data from animal studies suggest low oral and dermal toxicity
Chronic Effects: No long-term effects reported in humans; repeat or prolonged exposure can cause minor irritation
Skin Corrosion/Irritation: Mild irritation possible with prolonged contact
Serious Eye Damage/Irritation: May cause discomfort, redness, watering
Respiratory Sensitization: Not known to trigger allergic response
Carcinogenicity: Not listed by NTP, IARC, OSHA
Mutagenicity: No laboratory evidence
Reproductive Toxicity: No data suggesting a risk

Ecological Information

Ecotoxicity: No specific data available; expected to have low environmental toxicity due to limited water solubility and low usage volumes
Persistence and Degradability: Degrades slowly in the environment by hydrolysis and microbial action
Bioaccumulation: Not expected to accumulate in organisms
Mobility: Low mobility in soil and water
Other Adverse Effects: Prevent release into waterways to reduce unnecessary chemical burden

Disposal Considerations

Waste Handling: Collect and transfer spilled or unused material in sealed labeled waste containers
Disposal Methods: Incineration preferred by licensed chemical waste handler, or disposal in accordance with local regulations
Non-Contaminated Packaging: May be recycled or disposed of as non-hazardous waste depending on local policy
Additional Guidance: Avoid discharge to public wastewater and inform hazardous waste authorities prior to disposal

Transport Information

UN Number: Not regulated as a dangerous good for land, sea, or air transport
Proper Shipping Name: Not classified as hazardous for shipping
Transport Hazard Class: None assigned
Packing Group: Not required
Environmental Hazards: Not considered environmentally hazardous under current regulations
Transport Precautions: Keep container tightly closed, secure against physical damage, protect from moisture and heat during transit

Regulatory Information

Labeling Requirements: Follow lab or workplace chemical labeling rules including pictograms for skin/eye irritation
Inventory Listings: May appear on chemical inventories such as TSCA, EINECS, DSL based on supplier location
OSHA: Not specifically regulated beyond general chemical safety standards
SARA Title III: Not listed as an extremely hazardous substance
REACH: Registration may apply in Europe for larger importers or manufacturers
Other Information: Always consult national workplace and environmental safety legislation before use, storage, or disposal