Product Name: d-threo-(-)-2-amino-1-(p-nitrophenyl)-1,3-propanediol
Synonyms: N/A
CAS Number: 55-98-1
Recommended Use: Laboratory research, chemical synthesis, reference compound
Manufacturer Information: Refer to supplier or purchase documentation for contact details
Emergency Contact: Local Poison Control Center or Emergency Medical Services
Classification: Acute Toxicity (oral, dermal, inhalation) – Category 3; Eye Irritation – Category 2A; Specific Target Organ Toxicity – Single Exposure, Category 3
Signal Word: Danger
Hazard Statements: Toxic if swallowed, in contact with skin, or if inhaled. Causes serious eye irritation. May cause respiratory irritation.
Pictograms: GHS06 (skull and crossbones), GHS07 (exclamation mark)
Precautionary Statements: Avoid breathing dust or vapors. Wash hands thoroughly after handling. Wear protective gloves, clothing, and eye/face protection. Do not eat, drink or smoke when using this product.
Chemical Identity: d-threo-(-)-2-amino-1-(p-nitrophenyl)-1,3-propanediol
Chemical Formula: C9H12N2O4
Concentration: 98–100%
Impurities: Trace manufacturing by-products below reporting thresholds
Additives: None known
Inhalation: Remove affected person to fresh air. Seek medical attention if symptoms persist. Ensure victim is breathing and keep airways clear.
Skin Contact: Remove contaminated clothing and wash exposed skin with plenty of water for at least 15 minutes. Get medical help if irritation develops or persists.
Eye Contact: Flush eyes under running water for several minutes, lifting eyelids occasionally. Remove contact lenses if present and easy to do, resume rinsing. Obtain medical attention immediately.
Ingestion: Rinse mouth thoroughly with water. Do not induce vomiting. Never give anything by mouth to someone unconscious. Seek medical care at once.
Most Important Symptoms: Burning sensation, cough, shortness of breath, headache, dizziness, gastrointestinal discomfort, confusion.
Suitable Extinguishing Media: Carbon dioxide, dry powder, foam, or water spray. Use agents suitable for surrounding fire.
Hazards from Combustion: Toxic fumes including nitrogen oxides, carbon monoxide, carbon dioxide, and other hazardous gases may form.
Firefighting Equipment: Self-contained breathing apparatus (SCBA), full protective suit.
Precautions: Evacuate non-essential personnel. Move containers from fire area if possible without risk. Use water spray to cool unopened containers.
Special Procedures: Fight fire from a safe distance, avoid inhalation of combustion products.
Personal Precautions: Use personal protective equipment including gloves, goggles, lab coat, and respiratory protection if dust is produced. Keep away from unprotected people and pets. Ventilate the area.
Environmental Precautions: Keep material out of sewers, drains, and natural waterways. Prevent soil contamination.
Cleanup Methods: Sweep up without creating dust, place in clearly labeled container for disposal following local regulations. Avoid use of dry sweeping if dust clouds may form—use damp cloth or mop if possible.
Disposal: Refer to section on Disposal Considerations.
Decontamination: Wash area and equipment with water and detergent.
Safe Handling: Avoid inhaling dust and avoid contact with skin, eyes, and clothing. Use in a chemical fume hood. Only handle with appropriate safety gear. Prevent ingestion or inhalation by never eating, drinking, or smoking in the work area.
Storage Conditions: Store in a tightly closed container, in a cool, dry, well-ventilated area away from incompatible materials such as strong acids, strong bases, and oxidizers. Protect from light, heat, and moisture.
Incompatibilities: Oxidizing agents, acids, bases.
Segregation: Store apart from food, drink, and animal feed.
Security: Restrict access to those trained in handling hazardous chemicals.
Occupational Exposure Limits: None established for this compound. Use general dust exposure limit (10 mg/m³ for total dust, 3 mg/m³ for respirable dust) as guidance.
Engineering Controls: Work in a chemical fume hood with adequate local exhaust ventilation. Use enclosure or process isolation as needed.
Personal Protective Equipment: Protective lab coat, safety glasses with side shields or chemical splash goggles, chemical-resistant gloves (nitrile or neoprene recommended), and appropriate dust respirator where potential for airborne exposure exists; use a certified P2 or N95 respirator as minimum.
Hygiene Measures: Wash hands and face thoroughly after handling and before eating, drinking, or smoking. Remove contaminated clothing and wash before reuse.
Environmental Control: Contain discharges and prevent spread to environment; use closed transfer systems to prevent emissions.
Appearance: Pale yellow crystalline powder
Odor: Odorless or faint chemical odor
pH: No data available (solution dependent)
Melting Point: Approximately 140–142°C
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not determined
Evaporation Rate: No data available
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable
Solubility: Soluble in water, ethanol; limited solubility in chloroform, ether
Partition Coefficient (log Pow): Not determined
Decomposition Temperature: > 150°C
Viscosity: Not applicable (solid)
Stability: Stable at normal temperatures and pressures if stored properly in sealed containers away from light and moisture.
Hazardous Reactions: May react with strong oxidizers, acids, or bases to produce hazardous by-products.
Conditions to Avoid: Excessive heat, open flame, incompatible chemicals, direct sunlight, and moisture.
Incompatible Materials: Strong oxidizers, reducing agents, acids, bases.
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, and unidentified organic compounds in case of fire or thermal decomposition.
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact.
Acute Toxicity: Harmful if swallowed; LD50 (oral, rat): 50–200 mg/kg. Harmful if inhaled or absorbed through skin. Can cause severe irritation to eyes, skin, and respiratory tract.
Chronic Effects: Prolonged or repeated exposure may cause organ damage; neurological symptoms possible with significant exposure.
Symptoms: Nausea, vomiting, diarrhea, burning sensation, headache, dizziness, weakness, eye pain, visual disturbances.
Carcinogenicity: Not evaluated by IARC, NTP, or OSHA for carcinogenic potential.
Other Data: Not classified as mutagenic or reproductive toxin based on available evidence.
Toxicity: Harmful to aquatic life with long lasting effects. Acute aquatic toxicity estimated to be moderate for fish, invertebrates, and algae.
Persistence and Degradability: Expected to undergo slow degradation in the environment under standard conditions.
Bioaccumulation: Potential to bioaccumulate is low due to water solubility.
Mobility: Moderately mobile in soil; water solubility allows transport in aquatic environments.
Other Adverse Effects: Discharge to the environment should be minimized; harmful to organisms in soil and water.
Disposal Methods: Collect and place in a suitable closed container for disposal in accordance with national, regional, and local regulations; do not discharge into drains or natural waters.
Contaminated Packaging: Dispose of as hazardous chemical waste. Rinse containers and send to appropriate waste facility.
Other Precautions: Label waste containers clearly; avoid contact with municipal waste streams; do not attempt to neutralize with incompatible chemicals.
UN Number: Consult current regulations, may fall under UN2811 (Toxic solid, organic, n.o.s.)
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains d-threo-(-)-2-amino-1-(p-nitrophenyl)-1,3-propanediol)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II or III depending on quantity and concentration
Environmental Hazards: Marine pollutant
Special Precautions for User: Keep containers tightly sealed during transport, avoid spillage, inform transporters of hazardous nature.
EU Regulations: Subject to REACH restrictions as applicable, classified under GHS/CLP requirements
US Regulations: TSCA listed, SARA 313 not applicable for this material; OSHA hazardous chemical
Canada: DSL/NDSL status requires checking supplier data
Other International Regulations: Classified according to local chemical regulations; requires notification in certain jurisdictions
Label Elements: GHS-compliant labeling required including signal word, hazard pictograms and statements
Inventories: Verify with local regulatory lists for comprehensive status
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