Product Name: D(-)Threo-1-(4-nitrophenyl)-2-amino-1,3-propanediol
Synonyms: D-threo-2-amino-1-(p-nitrophenyl)-1,3-propanediol
Chemical Formula: C9H12N2O4
CAS Number: 52-89-1
Recommended Use: Laboratory reagent, pharmaceutical intermediate
Supplier Information: Refer to the source or manufacturer for detailed contact data
Emergency Phone Number: Refer to local chart or institution’s designated emergency contact
Classification: Acute toxicity (oral, dermal, inhalation), Skin irritation, Eye irritation, Specific target organ toxicity
Signal Word: Danger
Hazard Statements: Harmful if swallowed; Causes skin and eye irritation; May cause damage to organs through prolonged or repeated exposure.
Pictograms: Exclamation mark, Health hazard
Precautionary Statements: Avoid inhalation, ingestion, or skin contact; Use only outdoors or in a well-ventilated area; Wear protective gloves, clothing, and eye protection.
Other Hazards: Dust formation may lead to respiratory discomfort, prolonged skin exposure may result in dermatitis or rash.
Chemical Name: D(-)Threo-1-(4-nitrophenyl)-2-amino-1,3-propanediol
Synonyms: D(-)-threo-p-nitrophenylserinol
CAS Number: 52-89-1
EC Number: 200-153-7
Concentration: 98-100% as supplied
Impurities: Typical synthesis traces below 1% (refer to certificate of analysis for batch details)
Inhalation: Move affected person to fresh air; seek medical attention if breathing problems develop or persist.
Skin Contact: Remove contaminated clothing; wash skin with plenty of water and soap; seek medical advice if irritation continues.
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; obtain medical assistance.
Ingestion: Rinse mouth; seek immediate medical attention; do not induce vomiting unless instructed by medical personnel.
Most Important Symptoms: Respiratory discomfort, dermatitis, irritation, gastrointestinal distress
Advice for First Responders: Wear suitable personal protective equipment if exposure is likely, use gloves, goggles, and mask.
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: Direct water jet may spread fire
Specific Hazards: Combustion may produce toxic fumes of carbon monoxide, nitrogen oxides, and other irritating gases.
Advice for Firefighters: Use self-contained breathing apparatus and chemical protective gear; avoid inhaling vapors and fumes; stay upwind of fire zone.
Additional Considerations: Cool affected containers with water from a safe distance to prevent pressurized rupture.
Personal Precautions: Evacuate unnecessary personnel; ensure adequate ventilation; wear appropriate respiratory and protective gear.
Environmental Precautions: Avoid release to drains, surface water, groundwater, and soil; inform relevant authorities if substance enters the environment.
Spill Cleanup Methods: Use non-sparking tools, collect spilled material mechanically and transfer to labeled waste containers; avoid dust formation.
Decontamination: Wash spill area with water and detergent when clean-up is complete.
Disposal of Collected Material: Refer to disposal considerations section for guidelines.
Preventative Measures: Store absorbents and clean-up supplies near areas of potential risk.
Handling Instructions: Handle in well-ventilated storage rooms or fume hoods, employ local exhaust for dust control; wear gloves, protective eyewear, lab coat; avoid ingestion, inhalation, or contact with skin, eyes, or clothing.
Storage Recommendations: Keep container tightly closed in a cool, dry, and well-ventilated place away from incompatible substances such as strong acids, bases, and oxidizers.
Special Storage Requirements: Store out of direct sunlight; segregate from food and drink areas; clearly label all storage vessels.
Hygiene Practices: Do not eat, drink, or smoke in work areas; wash hands thoroughly after handling; remove contaminated clothing before breaks or leaving lab.
Control Parameters: Occupational exposure limits not established for this compound; use best available industrial hygiene practices.
Engineering Controls: Use chemical fume hood or local exhaust ventilation; maintain air concentrations below exposure thresholds.
Personal Protective Equipment: Chemical-resistant gloves (e.g., nitrile), splash-proof goggles, disposable lab coat/protective clothing, dust mask or full-face respirator if dust or aerosols generated.
Environmental Controls: Prevent substance entry into watercourses and drains.
Other Protection: Eyewash station and safety shower accessible in immediate work area.
Appearance: Pale yellow to yellow powder or crystalline solid
Odor: Mild or odorless
Odor Threshold: No data available
pH: Not relevant for solid; solution pH is slightly acidic to neutral
Melting Point/Freezing Point: 165-170°C
Boiling Point: Decomposes before boiling
Flash Point: Not combustible under typical conditions
Evaporation Rate: Not determined for this substance
Flammability: Non-flammable
Upper/Lower Flammability Limits: Not applicable
Vapor Pressure: Negligible at room temperature
Vapor Density: Not determined
Relative Density: No reliable data
Solubility: Soluble in water; limited solubility in organic solvents
Partition Coefficient (n-octanol/water): No data available
Auto-Ignition Temperature: Not determined
Decomposition Temperature: Above 170°C decomposes
Viscosity: Not applicable for solid
Chemical Stability: Stable under standard laboratory and storage conditions
Reactivity: Not reactive under normal conditions; may react with strong oxidizers or acids liberating toxic gases
Possibility of Hazardous Reactions: No dangerous reactions expected under intended conditions of use
Conditions to Avoid: Strong heating, contact with incompatible materials (strong acids or oxidizers), moisture exposure leading to hydrolysis
Incompatible Materials: Strong oxidizers, strong acids, organic anhydrides
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, possibly hydrogen cyanide under extreme conditions
Routes of Exposure: Ingestion, inhalation, dermal contact, eye contact
Acute Toxicity: LD50 (oral, rat): Approx. 250-500 mg/kg; Harmful in case of swallowing, inhalation, skin contact
Skin Corrosion/Irritation: Causes irritation on prolonged contact
Serious Eye Damage/Irritation: Causes eye irritation; may result in redness, tearing, or pain
Respiratory or Skin Sensitization: Potential for skin sensitization with chronic exposure
Germ Cell Mutagenicity: No reliable animal or epidemiological data
Carcinogenicity: Not classified as carcinogenic (according to available data)
Reproductive Toxicity: Insufficient data; avoid exposure if pregnant or breastfeeding
STOT - Single Exposure: May cause respiratory tract and gastrointestinal irritation
STOT - Repeated Exposure: Persistent or repeated contact may produce organ toxicity based on related compounds
Aspiration Hazard: Not an aspiration hazard based on physical and chemical properties
Toxicity: Harmful to aquatic life in high concentrations; potential to cause long-term environmental damage if released in large amounts
Persistence and Degradability: Compound expected to be only partly biodegradable; degradation in soil and water may take extended periods
Bioaccumulative Potential: No significant bioaccumulation anticipated based on molecular size and water solubility
Mobility in Soil: Expected to have moderate mobility in soils; risk of groundwater contamination if spilled
Other Adverse Effects: No ozone depletion or global warming risk; localized environmental effects possible
Waste Treatment Methods: Collect as chemical waste; incinerate in a licensed facility under controlled conditions
Contaminated Packaging: Rinse containers thoroughly before disposal or reuse; dispose of in accordance with local regulations
Disposal Recommendations: Avoid discharge into sewers, soil, or natural water bodies; package material for transport to approved disposal facility
Regulatory Compliance: Consult national, regional, and local laws for additional guidance
UN Number: Not classified as hazardous for transport under UN regulations
UN Proper Shipping Name: Not regulated
Transport Hazard Class(es): Not hazardous according to current criteria
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant
Special Precautions for User: Avoid spillage, ensure containers are sealed and labeled
Transport in Bulk: Not relevant; not classified for bulk transport
Safety Health and Environmental Regulations: Substance not specifically listed under major international chemical inventories such as REACH Annex XVII, SVHC, or US TSCA; always verify updated status with local and national authorities
Chemical Inventory Status: May be listed in some national chemical inventories; status can change as new regulations appear
Label Elements: Follow hazard labeling as per Globally Harmonized System (GHS) or local standards
Other Regulations: Users should assess workplace-specific regulations including storage, recordkeeping, safety training, and exposure monitoring requirements
Additional Information: Employers provide suitable training on chemical handling, emergency procedures, and personal protection by law in many areas
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