Product Name: Copper di-D-gluconate
Synonyms: Copper gluconate, Bis(D-gluconato) copper(II)
Chemical Formula: C12H22CuO14
CAS Number: 527-09-3
Intended Use: Dietary supplement ingredient, food additive, potential laboratory reagent
Manufacturer Information: Company name, address, and emergency contact numbers required according to national regulations
Emergency Phone Number: Provided by manufacturer or supplier on package insert or product label
Email Address: Manufacturer or supplier’s official contact for technical support or safety inquiries
Recommended Use: Used to supply copper in nutritional formulations and as a food fortifier in various consumer products
GHS Classification: Eye irritation (Category 2A), Acute toxicity oral (Category 4)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes serious eye irritation, potential for mild skin irritation after prolonged contact
Pictograms: Exclamation mark
Precautionary Statements: Prevent contact with eyes and skin, do not ingest, keep out of reach of children, wash hands thoroughly after handling, wear protective equipment
Route of Exposure: Inhalation of dusts, accidental ingestion, direct eye or skin contact
Target Organs: Eyes, gastrointestinal tract
Physical Hazards: Dust formation during handling, granules may present minor slip hazard if spilled
Chemical Name: Copper di-D-gluconate
Common Name: Copper gluconate
CAS Number: 527-09-3
Concentration: Typically supplied as a pure substance (99%–100%)
Impurities: May contain trace amounts of water, residual solvent, or reaction byproducts, all below thresholds set by food or pharma grade standards
Additives: No stabilizers or preservatives in standard product
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy, seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing, flush skin with plenty of water and mild soap, contact a physician if irritation occurs or persists
Inhalation: Move to fresh air, keep comfortable for breathing, seek medical attention if symptoms such as coughing or throat irritation develop
Ingestion: Rinse mouth with water, do not induce vomiting, get immediate medical advice, show this sheet to medical professionals if possible
Information for Doctor: Treat symptomatically, monitor for signs of copper toxicity or allergic reaction
Suitable Extinguishing Media: Water spray, dry powder, carbon dioxide, alcohol-resistant foam
Unsuitable Media: None known for copper di-D-gluconate itself, avoid high pressure water jets that may spread dust
Special Hazards: May decompose above 400°C, potentially releasing toxic copper oxide fumes
Protective Equipment: Self-contained breathing apparatus, chemical-resistant clothing, eye protection
Firefighting Instructions: Stay upwind, keep unnecessary personnel away, cool sealed containers with water spray to prevent rupture
Explosion Data: Product not considered a dust explosion hazard under normal conditions but can generate dust clouds that ignite in extreme cases
Personal Precautions: Evacuate unnecessary personnel, wear gloves, safety goggles, dust mask or respirator
Environmental Precautions: Prevent release into drains, sewers or waterways, contain any spills with inert material such as sand
Methods for Cleanup: Sweep up using non-sparking tools, avoid dust generation, collect residue in suitable labeled containers for approved disposal
Additional Guidance: Ventilate area, wash spill site after material collection, avoid allowing residues to dry and become airborne
Precautionary Handling: Use only with adequate ventilation, minimize dust formation, use personal protective equipment, wash thoroughly after handling
Safe Storage Conditions: Store tightly sealed in original container in cool, dry, well-ventilated area, away from strong acids, oxidizers, and heat sources
Incompatibility: Strong mineral acids, strong oxidizing agents, excessive moisture
Specific Requirements: Store away from food or animal feed to prevent accidental ingestion or cross-contamination
Packing Materials: Use moisture-resistant, chemically compatible containers
Occupational Exposure Limits: OSHA/NIOSH PEL and ACGIH TLV for copper (fume and dust): typically 1 mg/m³ (as Cu)
Engineering Controls: Use local exhaust ventilation or mechanical ventilation to control airborne levels below occupational limits
Personal Protective Equipment:
Appearance: Blue to blue-green crystalline powder, odorless
Molecular Weight: 453.84 g/mol
pH (1% solution): 4.0–6.0
Melting Point: Decomposes above 400°C
Solubility: Soluble in water at room temperature, insoluble in most organic solvents
Density: 2.0–2.4 g/cm³ (bulk powder)
Vapor Pressure: Not applicable (non-volatile solid)
Evaporation Rate: Not applicable
Partition Coefficient (n-octanol/water): No data available
Odor Threshold: Not applicable
Flash Point: Not flammable
Auto-ignition Temperature: No data available, does not auto-ignite under standard test conditions
Chemical Stability: Stable under recommended storage and handling conditions
Conditions to Avoid: Excessive heat, moisture, incompatible chemicals such as strong acids and oxidizers
Hazardous Reactions: May react with strong acids, liberating hazardous gases, may react slowly with oxidizers releasing heat
Decomposition Products: Thermal decomposition may generate copper oxides, carbon monoxide, and carbon dioxide
Polymerization: Does not undergo hazardous polymerization
General Logistical Issues: Caking can occur in humid environments, leading to handling and dispensing difficulties
Acute Toxicity: LD50 (oral, rat): approximately 300–1000 mg/kg
Potential Health Effects: Harmful if swallowed; may irritate the digestive tract, may irritate eyes and skin
Chronic Exposure: High cumulative copper exposure can lead to liver or kidney impacts; not considered carcinogenic
Symptoms of Exposure: Gastrointestinal distress such as nausea, vomiting, diarrhea if ingested, redness or pain in eyes, minor skin irritation
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA
Reproductive Toxicity: No conclusive evidence for adverse reproductive effects from typical exposures
Allergic Sensitization: Rare, but possible on broken skin or via respiratory route in hypersensitive individuals
Mutagenicity and Teratogenicity: No mutagenic effects observed in standard laboratory studies
Aquatic Toxicity: Toxic to aquatic life in high concentrations due to copper ion release; LC50 (fish, 96 hr): 0.01–1 mg/L
Persistence and Degradability: Organic portion (gluconate) is biodegradable; copper cation persists and may accumulate in soils and sediments
Bioaccumulation: Copper can bioaccumulate in aquatic organisms, but overall risk at environmentally relevant concentrations is moderate
Mobility in Soil: Copper binds to soil particles, limited mobility under neutral to slightly basic conditions
Other Adverse Effects: Releases to surface water should be minimized to prevent ecological damage to aquatic invertebrates and fish
Disposal of Product: Dispose as non-hazardous or hazardous chemical waste according to local, state, and federal regulations
Disposal of Packaging: Rinse containers, discard according to regulations for recyclable or hazardous waste, avoid flushing residues into drains
Special Precautions: Do not discharge into environment, avoid landfill if possible, use licensed waste contractor
Reuse or Recycling: Not recommended unless managed by commercial chemical processor with recovery processes for copper
UN Number: Not regulated for transport under UN, IMO, IATA, or DOT guidelines
Proper Shipping Name: Not classified as dangerous good
Transport Hazard Class: None assigned
Packing Group: None assigned
Marine Pollutant: Not listed but large-scale releases can present risk to aquatic environments
Special Transport Notes: Avoid exposure to moisture during transport, secure containers against damage and spillage
Inventory Listings: Listed on TSCA (US), EINECS/ELINCS (EU), DSL (Canada), and other international inventories as copper compound
Labeling Requirements: GHS-compliant labels indicating hazard class and precautionary information
OSHA Hazard Communication: Classified hazardous based on eye irritation and acute toxicity
Food and Drug Regulations: Approved for use as a trace mineral food additive in specified jurisdictions within recommended dose limits
SARA Title III (Sections 311/312): Acute health hazard
California Proposition 65: Copper not listed as cause of cancer or reproductive toxicity
Other Regulations: Compliance with all applicable workplace, transport, and environmental protection regulations remains necessary
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