Product Name: Chloropropanediol
Synonyms: 3-Chloro-1,2-propanediol; alpha-Chlorohydrin; 1,2-Propanediol, 3-chloro-
Chemical Formula: C3H7ClO2
CAS Number: 96-24-2
Recommended Use: Intermediate in organic synthesis, chemical manufacturing, laboratory applications
Supplier Details: Manufacturer address and emergency contact information provided on shipment paperwork and upon request
Emergency Telephone: Refer to local poison control center or as provided by supplier
Classification: Acute toxicity (oral, dermal, inhalation), skin irritation, serious eye damage/eye irritation, STOT single exposure (nervous system), carcinogenicity (IARC 2B)
Label Elements: Danger pictogram, signal word: DANGER,
Hazard Statements: Harmful if swallowed, in contact with skin, or inhaled; causes serious eye irritation; may cause damage to organs; possibly carcinogenic to humans
Precautionary Statements: Avoid breathing vapors and mists, wash hands thoroughly after handling, wear protective gloves/eye protection/face protection, do not eat/drink/smoke during use
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Irritation, headache, dizziness, nausea, burns, long-term exposure risks
Chemical Name: 3-Chloro-1,2-propanediol
Concentration (%): >98
Impurities: None significant for classification
Additives: None
CAS Number: 96-24-2
EC Number: 202-492-4
Molecular Weight: 110.54 g/mol
General Advice: Move victim from exposure source, ensure access to fresh air and immediate medical attention if necessary
Inhalation: Remove to fresh air; monitor for breathing difficulties; if symptoms persist, seek medical attention
Skin Contact: Remove contaminated clothing; rinse skin with plenty of water and soap; seek care if irritation develops
Eye Contact: Rinse cautiously with water for at least 15 minutes; remove contact lenses if present and easy to do; seek medical attention
Ingestion: Rinse mouth with water; do not induce vomiting; seek medical attention immediately
Note for Physicians: Treat symptomatically; monitor nervous system function and irritation effects
Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Incompatible Extinguishers: Do not use water jet; risk of spreading contamination
Specific Hazards: Decomposition produces irritating and toxic gases (hydrogen chloride, carbon oxides)
Special Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective clothing
Fire-Fighting Procedures: Cool containers with water; prevent runoff from contaminating water supplies; contain fire residue for disposal
Personal Precautions: Avoid contact with skin, eyes, and clothing; evacuate area if needed; ventilate affected area
Protective Equipment: Use gloves, goggles, and suitable protective clothing, respirator if vapor risk present
Environmental Precautions: Prevent release to sewers, waterways, and soil
Containment: Stop leak if safe to do so; contain spill with inert absorbent (sand, earth)
Cleanup: Collect in suitable, tightly closed containers for disposal; wash area thoroughly after collection
Handling: Use with adequate ventilation; minimize aerosol or vapor generation; avoid prolonged or repeated exposure; never eat, drink, or smoke during handling
Storage Conditions: Store in a cool, well-ventilated area; keep container tightly closed and clearly labeled; segregate from incompatible materials like strong oxidizers and acids
Incompatible Materials: Oxidizing agents, acid chlorides, acid anhydrides
Specific Requirements: Use corrosion-resistant shelving or secondary containers as needed; regularly inspect storage areas for leaks, corrosion, damage
Occupational Exposure Limits: ACGIH TLV or national limits may apply; consult SDS from supplier or local authorities
Engineering Controls: Use local exhaust ventilation, closed systems, or other engineering measures to limit vapor exposure
Personal Protective Equipment: Chemical-resistant gloves (nitrile, rubber), safety goggles, face shield, lab coat or full-body chemical apron
Respiratory Protection: Use full-face respirator for high concentrations or inadequate ventilation situations; filter type ABEK as minimum
Hygiene Measures: Change contaminated clothing; do not reuse until thoroughly cleaned; wash hands before eating, drinking, smoking, or using restroom
Appearance: Colorless to pale yellow liquid
Odor: Sweet, faint, chloroform-like
Odor Threshold: Not available
pH: Not available
Melting Point/Freezing Point: -40°C
Boiling Point: 213°C
Flash Point: 131°C (closed cup)
Evaporation Rate: Not available
Flammability (solid/gas): Not flammable by standard classification
Vapor Pressure: 0.04 mm Hg @ 25°C
Vapor Density: 3.8 (air=1)
Relative Density: 1.32 g/cm³ @ 20°C
Solubility: Miscible with water
Partition Coefficient (n-octanol/water): log Kow = -1.21
Auto-Ignition Temperature: >400°C
Decomposition Temperature: Not established
Viscosity: Not available
Chemical Stability: Stable under recommended conditions; light and air exposure may increase degradation
Reactivity: Reacts with oxidizers, acid chlorides, alkali metals
Hazardous Reactions: May release toxic gases (hydrogen chloride, carbon oxides) upon decomposition
Conditions to Avoid: Heat, flames, sparks, incompatible materials
Incompatible Materials: Strong oxidizers, strong acids, alkali metals
Hazardous Decomposition Products: Hydrogen chloride gas, phosgene, carbon monoxide, carbon dioxide
Acute Toxicity: LD50 (oral, rat): 192 mg/kg; LD50 (dermal, rabbit): 290 mg/kg; LC50 (inhalation, rat, vapor): data limited
Skin Corrosion/Irritation: Causes irritation, redness, possible burns with long contact
Serious Eye Damage/Irritation: Causes severe irritation, pain, redness
Respiratory Sensitization: Expected to cause respiratory irritation
Carcinogenicity: IARC Group 2B (possibly carcinogenic to humans), listed by NTP as anticipated human carcinogen
Specific Target Organ Toxicity (Single/Repeated): Risk of neurotoxicity at high or repeated exposures
Other Effects: Headache, dizziness, nausea, vomiting, central nervous system depression
Aquatic Toxicity: Toxic to aquatic organisms; LC50 (Fish, Leuciscus idus, 96 h): 70 mg/L
Persistence and Degradability: Moderately biodegradable in water and soil
Bioaccumulative Potential: Low (log Kow <0)
Mobility in Soil: Expected to have high mobility; miscible with water, potential groundwater contaminant
Other Adverse Effects: May cause long-term adverse effects in aquatic environments if uncontrolled release occurs; do not allow to enter drains or surface water
Waste Disposal Methods: Incineration in chemical incinerator equipped with afterburner and scrubber; do not dispose of via municipal sewers
Container Disposal: Triple rinse, remove labels, puncture, and submit for chemical waste collection
Contaminated Packaging: Treat as hazardous waste; consult local, regional, and national regulations for proper disposal
Regulatory Considerations: Waste must be handled per country, state, and local hazardous waste requirements
UN Number: 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 3-chloro-1,2-propanediol)
Transport Hazard Class: 6.1 (toxic substances)
Packing Group: III
Label: Toxic
Special Precautions for Users: Avoid release into the environment; keep away from incompatible materials; ensure secure containers
Transport Regulations: Regulated under IMDG, ICAO/IATA, ADR/RID for land, air, and sea
TSCA (USA): Listed; subject to reporting requirements
REACH (EU): Registration required for import and usage above one ton per year; subject to restrictions
WHMIS (Canada): Class D1A; very toxic material; D2B (toxic effects)
OSHA (USA): Hazardous under Hazard Communication Standard
SARA Title III Sections 302/313 (USA): Listed chemical
State and National Listings: Subject to state reporting and right-to-know programs
Other Standards: Ensure compliance with industry-specific rules for use, storage, emissions, and worker exposure
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