Product Name: Chlorhexidine Gluconate Solution USP
Synonyms: 1,1'-Hexamethylenebis[5-(p-chlorophenyl) biguanide] digluconate
Recommended Use: Antiseptic, disinfectant for skin, wound cleanser, preservative in pharmaceuticals
Manufacturer/Supplier: [Specific Manufacturer Details]
Emergency Phone: [Emergency Contact Information]
CAS Number: 18472-51-0
GHS Classification: Eye irritation (Category 2), Skin irritation (Category 2), Aquatic toxicity (acute and chronic, Category 1)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, causes skin irritation, toxic to aquatic life with long-lasting effects
Pictograms: Exclamation mark, environment
Precautionary Statements: Wear protective gloves, protect eyes and face, avoid release to environment, wash skin thoroughly after handling, dispose of contents in accordance with local regulations
Active Ingredient: Chlorhexidine gluconate (typical concentration: 2% w/v or 4% w/v)
Other Components: Water, isopropyl alcohol (in some formulations), fragrance (in some products), surfactants, coloring agents (if colored), stabilizers
Impurities: Levels known to be very low, not considered significant under normal use conditions
Eye Contact: Rinse eyes with water for several minutes, remove contact lenses if present and easy to do, seek medical help if irritation persists
Skin Contact: Wash affected area with plenty of water and mild soap, if irritation or rash develops, contact a doctor
Inhalation: Move person to fresh air, seek medical advice if symptoms persist, not typically a risk under intended use
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, call poison control center or seek immediate medical attention
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Direct high-pressure water streams can spread the liquid
Special Hazards: In case of fire, hazardous decomposition products such as nitrogen oxides, hydrogen chloride, and carbon oxides could be released
Protective Equipment: Wear self-contained breathing apparatus, full protective gear, avoid inhalation of smoke or vapors
Personal Precautions: Wear gloves and eye protection, ventilate area if possible, avoid skin and eye contact
Environmental Precautions: Prevent substance from entering drains, waterways, or soil
Cleanup Methods: Absorb with sand or inert absorbent, collect in suitable containers for disposal, wash spill area thoroughly after cleaning, do not use combustible material for absorption
Handling: Avoid direct contact with eyes, skin, and clothing, use in well-ventilated spaces, wear personal protective equipment as required by risk assessment, refrain from eating, drinking, or smoking during use
Storage: Keep container tightly closed when not in use, store away from strong oxidizers, acids, and bases, avoid excessive heat or direct sunlight, keep out of reach of children and pets, store at temperatures recommended by manufacturer
Engineering Controls: Use local ventilation, eyewash stations, safety showers where large volumes are handled
Personal Protection: Gloves (nitrile, latex), safety glasses with side shields or face shield, protective clothing for bulk handling
Respiratory Protection: Not usually needed under normal use, use a suitable mask in case of inhalation risk (e.g., during spills or splashes)
Hygiene Measures: Wash hands after handling, remove contaminated clothing before eating or leaving work area
Appearance: Clear or pale yellow liquid, sometimes colorless
Odor: Faint, medicinal odor
pH: Generally around 5.0–6.5 (depending on formulation)
Melting Point / Freezing Point: Below 0°C (freezing point), decomposes before boiling
Boiling Point: Approximately 100°C (water-based)
Flash Point: Not considered a fire risk in aqueous solution, if alcohol present flash point can drop (safe handling required)
Solubility: Soluble in water
Density: Typically around 1.06–1.13 g/mL
Vapor Pressure: Not significant under normal conditions
Chemical Stability: Stable under recommended storage conditions
Incompatibility: Strong oxidizers, anionic compounds, soap, acids, and bases can reduce antimicrobial efficacy or cause degradation
Hazardous Reactions: Not likely under normal handling, avoid mixing with incompatible materials
Decomposition Products: At high temperatures or with strong acids, can produce carbon oxides, nitrogen oxides, hydrogen chloride
Routes of Exposure: Skin, eyes, ingestion, inhalation (rare)
Acute Effects: Direct contact leads to irritation of skin and eyes, may trigger allergic reactions in sensitive persons
Chronic Effects: No indication of carcinogenicity or sensitization with recommended use, large or prolonged exposure can cause dermatitis or mucosal irritation
LD50 (oral, rat): 2000 mg/kg (approximate, varies based on concentration and test)
Symptoms: Burning, redness, possible swelling or blistering on skin or mucosa, possible gastrointestinal upset if swallowed
Other Information: Rare reports of hypersensitivity, especially in dental and surgical settings
Aquatic Toxicity: Very toxic to aquatic organisms, may cause long-term adverse effects in aquatic environments
Degradability: Partially biodegradable in environment, persistence based on formulation and concentration
Bioaccumulation: No significant bioaccumulation observed in most studies
Other Effects: Prevent entry to waterways, avoid contamination of soil and groundwater during use and disposal
Disposal Methods: Dispose of in accordance with national and local regulations, do not flush in large amounts to drains or surface water
Product Waste: Small amounts can be diluted and disposed as household or lab waste, large volumes require hazardous waste procedures
Packaging Waste: Rinse empty containers before disposal, follow recycling or disposal standards for chemical containers
UN Number: Not regulated as a dangerous good in most aqueous forms, but alcohol-containing versions might fall under relevant hazardous goods codes
Proper Shipping Name: Chlorhexidine gluconate solution (formulation-specific)
Hazard Class: Not generally classified, but observe specific rules if flammable components present
Packing Group: Depends on contents, usually not applicable
Labeling Requirements: Use standard labelling for disinfectants, mark all containers clearly with identification and hazard warnings
U.S. Regulations: Listed under TSCA inventory, subject to OSHA Hazard Communication Standard, recognized by FDA as an over-the-counter drug for certain uses
EU Regulations: REACH registered, subject to CLP (Classification, Labelling, and Packaging), included in Biocidal Products Regulation (BPR) list
Other jurisdictions: Australia (AICS), Canada (DSL), Japan (ENCS) include chlorhexidine gluconate in chemical inventories
Workplace Controls: Employers required to provide access to MSDS, implement training and exposure controls, follow reporting requirements for spills or worker injury
Product Restrictions: Some jurisdictions may limit concentrations or require additional hazard labeling on certain formulations, particularly alcohol-based products
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