Product Name: Chlorhexidine Gluconate Solution API
Chemical Formula: C22H30Cl2N10•2C6H12O7
CAS Number: 18472-51-0
Use: Commonly found in antiseptic and disinfectant products for skin and mucous membranes, especially in healthcare settings.
Synonyms: 1,1'-Hexamethylenebis[5-(4-chlorophenyl)biguanide] digluconate
Manufacturer Details: Refer to the product label or supplier contact for specific information.
Emergency Contact: Emergency response services and poison control centers provide assistance in case of incident.
Classification: Eye damage/irritation (Category 1), Skin corrosion/irritation (Category 2), Acute toxicity oral and dermal (Category 4)
Signal Word: Danger
Hazard Statements: Causes serious eye damage, causes skin irritation, harmful if swallowed, may be harmful in contact with skin, may cause allergic skin reaction
Precautionary Statements: Avoid contact with eyes, skin, and clothing; Do not ingest; Use only with adequate ventilation; Wear protective clothing; In case of accident, seek medical advice immediately.
Physical Hazards: Contact with certain materials may cause violent reaction; May corrode some metals.
Environmental Hazards: Toxic to aquatic life with long lasting effects; Prevent release to environment.
Chlorhexidine Gluconate: 19.5% w/v (active ingredient)
Water: Purified, used as main solvent
Other Ingredients: May contain small amounts of surfactants or stabilizers depending on the supplier
Impurities: Trace residues, typically below established safety thresholds
Physical State: Liquid, clear to slightly yellowish
Inhalation: Move to fresh air. If breathing becomes difficult, seek medical help.
Skin Contact: Remove contaminated clothing and wash thoroughly with soap and water. See physician if irritation persists.
Eye Contact: Rinse carefully with plenty of water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing and get immediate medical attention.
Ingestion: Rinse mouth. Do not induce vomiting. If patient feels unwell, contact poison control center or physician.
Acute and Delayed Symptoms: Eye damage, irritation, possible respiratory or skin allergic reactions.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam.
Special Hazards Arising from Substance: Emits toxic fumes under fire conditions, including HCl and nitrogen oxides.
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear.
Special Procedures: Prevent runoff from entering drains and surface water; Move containers from fire area if possible.
Personal Precautions: Avoid contact with spilled material; Use gloves, goggles, protective clothing.
Environmental Precautions: Prevent further leakage or spillage if safe; Avoid discharge into drains, watercourses, or soil.
Methods for Cleanup: Absorb with inert material (sand, earth, vermiculite), scoop up and transfer to appropriate waste container. Wash spill site after material pickup is complete.
Notification: Report large leaks as required by local, state, or national regulations.
Handling: Wear appropriate PPE. Avoid ingestion, inhalation, or skin and eye contact. Use with adequate ventilation. Wash hands after handling.
Storage: Store in tightly closed containers in a cool, dry, well-ventilated area away from heat, direct sunlight, oxidizers, strong acids and bases.
Incompatible Materials: Do not store near acids, alkalis, or oxidizing materials.
Storage Temperature: Store at temperatures recommended by the manufacturer or in general between 15-25°C (59-77°F).
Recommended Exposure Limit: No established occupational exposure limits; follow workplace guidelines and good laboratory practices.
Engineering Controls: Use adequate local exhaust ventilation to keep airborne concentrations as low as possible.
Personal Protective Equipment: Chemical-resistant gloves, protective goggles or face shield, lab coat or apron, and suitable respiratory protection if vapor or aerosol risk exists.
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling and at end of work day; Do not eat, drink, or smoke in application area.
Environmental Controls: Prevent release to environmental systems, keep away from drains or rivers.
Appearance: Clear or slightly yellowish liquid
Odor: Mild, characteristic
Odor Threshold: Not determined
pH: 5.0 – 7.0
Boiling Point: Above 100°C (212°F)
Melting Point: Not applicable (liquid state)
Flash Point: Not flammable
Evaporation Rate: Similar to water
Solubility: Miscible with water
Vapor Pressure: Negligible
Vapor Density: Not determined
Specific Gravity: 1.06 – 1.10 (at 20°C)
Partition Coefficient (n-octanol/water): Not determined
Decomposition Temperature: Data not available
Viscosity: Thin, watery
Chemical Stability: Stable under recommended handling and storage conditions
Reactivity: Not reactive under normal use
Conditions to Avoid: Excess heat, strong acids, strong alkalis, oxidizing agents
Hazardous Decomposition Products: HCl gas, nitrogen oxides under fire extremes
Polymerization: Will not occur
Incompatibility: Strong acids, strong bases, oxidizers
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity (oral): LD50 rat (oral): 1800 mg/kg (for Chlorhexidine base)
Acute Toxicity (dermal): LD50 rabbit: >2000 mg/kg
Skin Corrosion/Irritation: Causes irritation or burns, especially on prolonged contact
Eye Damage/Irritation: Causes serious damage, potentially irreversible
Respiratory Sensitization: Not expected under normal use, may cause irritation upon inhalation of aerosols
Skin Sensitization: May provoke allergic contact dermatitis in susceptible individuals
Chronic Effects: Continuous exposure may cause contact dermatitis or respiratory effects
Carcinogenicity: Not classified as carcinogenic by NTP, IARC, OSHA
Mutagenicity/Reproductive Toxicity: No conclusive data for mutagenic or reproductive risks in humans
Symptoms of Overexposure: Headache, nausea, stomach upset, skin or eye irritation
Ecotoxicity: Toxic to aquatic organisms, may cause long-term adverse effects in aquatic environments
Aquatic Toxicity: LC50 Fish (96h): 2.08 mg/L; EC50 Daphnia (48h): 0.087 mg/L
Persistence and Degradability: Not readily biodegradable
Bioaccumulation Potential: Low potential due to high water solubility
Mobility in Soil: Likely to be mobile in water, binds moderately to soil particles
Other Adverse Effects: Avoid direct discharge to sewer or storm water drains due to toxicity to micro-organisms and aquatic life
Waste Treatment Methods: Dispose of contents/container in accordance with local/regional/national/international regulations
Product Disposal: Do not pour into drains or watercourses; Large quantities require chemical treatment or incineration
Packaging Disposal: Triple rinse empty containers before disposal; Do not reuse packaging for other materials
Special Precautions: Handle any leftover solutions as hazardous waste
Regulatory Disposal Codes: Refer to appropriate hazardous waste classification codes for disposal
UN Number: Not assigned for concentrations below threshold for hazardous transport
Transport Hazard Class: Usually not regulated as dangerous good under ADR, IMDG, IATA for diluted solutions
Packing Group: Not applicable for concentrations used in healthcare
Shipping Name: Chlorhexidine Gluconate Solution
Transport Precautions: Avoid spillage, secure tightly; Transport upright, away from incompatible materials
Environmental Hazards: Not considered marine pollutant at normal concentrations
OSHA/WHMIS Classification: Eye and skin irritant; regulated under OSHA Hazard Communication Standard
EPA: Listed as antimicrobial active ingredient, subject to FIFRA regulations
EU Regulations: Not a hazardous chemical according to Regulation (EC) No. 1272/2008 for diluted forms; Concentrates may require CLP labeling
FDA: Approved active ingredient in certain drug and dental products, with use restrictions regarding concentration
Other National Regulations: May fall under specific national safety and workplace regulations; Refer to local requirements
Label Elements: Product label must include appropriate hazard and precautionary statements according to jurisdiction
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