Material Safety Data Sheet: Catharanthine Tartrate

Identification

Product Name: Catharanthine Tartrate
Synonyms: Catharanthine hydrogen tartrate, D-Catharanthine tartrate
Chemical Formula: C21H24N2O2·C4H6O6
CAS Number: 58896-48-1
Molecular Weight: 350–400 g/mol (depends on salt form)
Manufacturer: [Company information]
Recommended Use: Laboratory research and chemical studies
Restrictions: Not for drug, household, or food use

Hazard Identification

Classification: Acute toxicity (Oral, Dermal, Inhalation), Eye irritation, Skin irritation
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation
Pictograms: Exclamation mark
Signal Word: Warning
Precautionary Statements: Avoid breathing dust, wear protective gloves and eye protection, wash hands after handling

Composition / Information on Ingredients

Chemical Name: Catharanthine Tartrate
CAS Number: 58896-48-1
Concentration: 98–100% (pure salt form)
Impurities: Minimal, expected only as trace remnants from synthesis
Other Components: No additional stabilizers or major additives

First Aid Measures

Inhalation: Move exposed individual to fresh air, keep airway open, seek medical attention for persistent symptoms
Skin Contact: Rinse area with plenty of water, remove contaminated clothing, call a physician for persistent irritation
Eye Contact: Flush eyes with water for at least 15 minutes, seek immediate medical attention
Ingestion: Rinse mouth, drink water if conscious, do not induce vomiting unless directed by medical personnel, call poison control or a doctor
Most Important Symptoms: Nausea, respiratory discomfort, eye redness, skin rash

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, alcohol-resistant foam
Special Hazards: Emits toxic fumes under fire conditions, including nitrogen oxides and carbon oxides
Protective Equipment: Self-contained breathing apparatus and full protective clothing
Advice for Firefighters: Move containers from fire area if possible to do so safely, use water in flooding quantities for large fires
Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide

Accidental Release Measures

Personal Precautions: Avoid contact with skin and eyes, ventilate area
Protective Equipment: Gloves, lab coat or suitable protective clothing, safety goggles, face shield if needed
Spill Cleanup: Sweep up solid material without generating dust, place in sealed containers for disposal, wash spill site with water after initial cleanup
Environmental Precautions: Prevent release into water systems and drains, notify authorities if significant quantities enter environment

Handling and Storage

Handling: Handle in a chemical fume hood, avoid inhaling dust, minimize direct contact
Storage Conditions: Keep in tightly closed containers, store in a cool, dry, well-ventilated area, avoid exposure to sunlight and moisture
Incompatibilities: Strong oxidizing agents, strong acids, bases
Specific End Uses: Laboratory-scale only

Exposure Controls and Personal Protection

Engineering Controls: Use laboratory fume hood, ensure eye wash station and emergency shower are available
Personal Protective Equipment: Safety goggles, chemical-resistant gloves, laboratory coat, particulate respirator if dust formation possible
Hygiene Measures: Wash hands after handling, remove contaminated clothing, do not eat or drink in workplace
Exposure Limits: No occupational exposure limit assigned, minimize exposure by standard lab practices

Physical and Chemical Properties

Physical State: Solid
Appearance: White to off-white crystalline powder
Odor: Odorless or faint chemical smell
Melting Point: 170–190°C (decomposes above 200°C)
Boiling Point: Data not applicable (decomposition occurs before boiling)
Solubility: Soluble in water, slightly soluble in organic solvents such as ethanol
pH: 5.0 – 6.5 in aqueous solution
Vapor Pressure: Not determined
Density: Approx. 1.3–1.5 g/cm³

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Not reactive under normal laboratory use
Hazardous Reactions: Possible reaction with strong oxidizers and strong acids
Conditions to Avoid: Excessive heat, sunlight, exposure to moisture or air
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide released when burned or decomposed

Toxicological Information

Acute Toxicity: Harmful if ingested, inhaled, or in contact with skin at high enough doses
Symptoms: Nausea, dizziness, skin redness, eye burning, respiratory discomfort
Chronic Exposure: May cause prolonged effects on nervous system, insufficient long-term data in humans
Carcinogenicity: No data for carcinogenic potential; not classified as carcinogen by OSHA, IARC, NTP
Other Effects: May cause irritation or allergic reactions in sensitive individuals

Ecological Information

Ecotoxicity: Toxic to aquatic organisms at high concentrations
Persistence and Degradability: Data not fully established, may persist in soil and water
Bioaccumulative Potential: Limited evidence, structure suggests low potential for bioaccumulation
Mobility in Soil: Likely disperses in water, may leach into groundwater
Other Adverse Effects: Avoid release into the environment, follow laboratory disposal protocols

Disposal Considerations

Waste Treatment Methods: Collect as hazardous chemical waste, incinerate in a chemical incinerator with afterburner and scrubber
Disposal of Contaminated Packaging: Dispose of as unused product under local and national regulations
Options: Consult a licensed waste disposal contractor for proper and compliant disposal solutions
Precautions: Ensure complete protection for waste handlers using gloves, goggles, and masks during disposal

Transport Information

UN Number: Not classified as dangerous goods for transport
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Proper Shipping Name: Not regulated
Special Precautions: Use robust, sealed packaging to prevent leaks or dust emission, label outer container appropriately, protect from accidental breakage in transit

Regulatory Information

US TSCA: Not listed
EU REACH: Not registered or evaluated
SARA Title III (Sections 302/304/311/312/313): Not subject
OSHA Hazard Communication: Meets OSHA hazard criteria
State Regulations: Follow individual state guidelines
Other Regulations: Laboratory use only; not for use in foods, drugs, or cosmetics as per federal directives