Material Safety Data Sheet: Calcium Borogluconate

Identification

Product Name: Calcium Borogluconate
Chemical Family: Calcium Salt Solution
Recommended Use: Veterinary injectable for treatment of milk fever and calcium deficiency
Manufacturer: Consult label or supplier documentation
Emergency Contact: Refer to local emergency telephone number
SDS Number: Supplied by distributor, updated with each production lot
Synonyms: Calcium gluconate and borogluconate solution
Formula: Mixture containing calcium gluconate, boric acid, water
CAS Numbers: Calcium gluconate 299-28-5, Boric acid 10043-35-3

Hazard Identification

Classification: Not classified as hazardous under GHS for general users, but caution required due to injection route
Label Elements: May cause skin, eye, or respiratory irritation; harmful if injected improperly, avoid splashing or inhalation
Warnings: Irritating to damaged skin or mucosa; can cause adverse symptoms if administered by untrained personnel
Physical Hazards: Spillage causes slippery floors; large amounts in water may cause pH changes
Environmental Effects: Low risk at recommended use but persistent high concentrations may be harmful to aquatic life due to boron content
Emergency Overview: Clear, odorless solution with slight sweet flavor, can aggravate skin ailments or respiratory sensitivities upon repeated contact

Composition / Information on Ingredients

Active Ingredient: Calcium gluconate, concentration typically 20-23% w/v
Secondary Active Ingredient: Boric acid, typically 5-10% w/v
Inactive Ingredients: Sterile water for injection, trace magnesium gluconate (sometimes present), stabilizers
Impurities: Low; pharmaceutical-grade chemicals employed; manufacturer test results available
Total Solution: Typically administered as a clear, sterile, ready-to-use injectable

First Aid Measures

Inhalation: Remove exposed individual to fresh air, monitor for trouble breathing, contact physician if symptoms persist
Skin Contact: Wash area with soap and water, remove contaminated clothing, seek medical advice for irritation
Eye Contact: Rinse immediately with water for at least fifteen minutes, lift eyelids occasionally, consult ophthalmologist for persistent irritation
Ingestion: Rinse mouth, offer water, and seek medical attention for gastrointestinal symptoms or large exposure
Injectable Exposure: Only trained personnel should administer, misuse can lead to tissue injury or systemic effects; treat overdoses according to poison control recommendations and supportive care

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, foam, dry chemical, or CO2 for surrounding fire; solution itself is not flammable
Unsuitable Media: None identified, chemical is water-based and non-combustible
Unusual Fire Hazards: Containers exposed to fire may burst from pressure buildup; avoid inhaling fire decomposition products
Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes
Hazardous Combustion Products: Calcium oxide, boron oxides, carbon oxides possible if solution fully evaporates and residue is involved in fire; keep hoses available to dilute spills and residues

Accidental Release Measures

Personal Precautions: Isolate spill area from unprotected individuals, avoid breathing mist, wear gloves and goggles if cleaning
Environmental Precautions: Prevent run-off into waterways or storm drains, absorb with inert material for collection
Methods for Containment and Cleaning: Dike to control spill, absorb with sand or non-combustible material, collect and dispose according to regulatory requirements; flush residue with water after collection
Small Spills: Wipe up with paper towel or cloth, dispose of waste using municipal solid waste route unless local regulation differs
Large Spills: Notify authorities, avoid entry to confined spaces, ensure ventilation

Handling and Storage

Handling: Wear gloves when opening ampoules or bottles, avoid eye and dermal contact, never extract with unsterile equipment, restrict access to qualified personnel
Storage: Keep in original container in a cool, dry place, avoid freezing, protect from light to maintain potency
Incompatible Materials: Do not store with strong acids, bases, or with oxidizers
Storage Temperature Range: Typically 8-25 °C (46-77 °F), check specific product literature
Special Precautions: Store away from food and feed, maintain inventory log, segregate expired product for disposal

Exposure Controls and Personal Protection

Engineering Controls: Use in well-ventilated area, no special ventilation needed for casual handling
Eye Protection: Chemical splash goggles recommended for bulk handling or frequent transfers
Skin Protection: Disposable latex or nitrile gloves; lab coats or aprons limit risk of secondary exposure
Respiratory Protection: Not expected to require respiratory protection unless aerosolized or during fire
Occupational Exposure Limits: Consult specific limits for calcium salts and boric acid; TWA for boric acid (ACGIH): 2 mg/m3 (inhalable fraction), monitoring suggested for chronic industrial exposure

Physical and Chemical Properties

Appearance: Clear, colorless to faintly yellow solution
Odor: Odorless
pH: 6.5-7.5 at use dilution
Boiling Point: ~100 °C (212 °F)
Melting Point: Not applicable (aqueous solution)
Solubility: Completely miscible with water
Specific Gravity: 1.05-1.12
Viscosity: Thin, similar to water
Vapor Pressure: Not applicable
Flammability: Non-flammable
Partition Coefficient (n-octanol/water): Not established
Evaporation Rate: Similar to water

Stability and Reactivity

Chemical Stability: Product stable under normal recommended conditions, sensitive to heat, light, and contamination
Reactivity: Unlikely to react violently with other chemicals under routine use, avoid strong acids or bases
Possibility of Hazardous Reactions: Contact with incompatible substances could produce toxic gases
Conditions to Avoid: Excessive heat, freezing, contamination with non-sterile objects
Decomposition Products: Calcium and boron oxides possible if boiled dry or burned
Polymerization: Hazardous polymerization has not been observed

Toxicological Information

Acute Toxicity: Low toxicity by oral, dermal, and inhalation routes at therapeutic concentrations
Chronic Toxicity: Prolonged excessive exposure to boric acid may cause reproductive harm or kidney effects; always use as directed
Symptoms of Overdose: Confusion, heart arrhythmia, skin flushing, vomiting, weakness
Skin Corrosion/Irritation: Mild, possible irritation at injection or spill site
Eye Damage/Irritation: May cause temporary discomfort or redness
Carcinogenicity: No evidence in humans at recommended exposures
Mutagenicity: Data not conclusive
Other Effects: Overdose may lead to hypercalcemia, tremor, seizure in animals

Ecological Information

Ecotoxicity: Significant hazard unlikely in normal use; large-scale release may increase boron levels and affect aquatic invertebrates
Persistence and Degradability: Components are biodegradable and do not persist in small quantities, boron could accumulate in soil
Bioaccumulation Potential: Low, especially at environmental doses
Mobility In Soil: Highly mobile in water, rapidly diffuses into surface water and soil
Other Adverse Effects: Laboratories and clinics should take care to prevent waste from entering local water systems untreated

Disposal Considerations

Disposal Methods: Collect unused product and rinse water in closed containers, send to hazardous waste treatment where required
Container Disposal: Rinse thoroughly, remove labels, render unsuitable for reuse, recycle or landfill as per regulations
Waste Code: Consult local and federal regulations for appropriate designation, may be classified as non-hazardous but consult boric acid thresholds
Precautions: Never discharge into drains, surface or ground water in raw form, coordinate with licensed waste disposal contractor
Expired Product: Segregate and schedule for incineration or chemical treatment if local landfill criteria are not met

Transport Information

UN Number: Not regulated under most transportation codes
Proper Shipping Name: Calcium borogluconate solution
Transport Hazard Class: Not a hazardous material for road, air, or sea transport
Packing Group: None assigned
Special Precautions: Secure container to prevent leakage, keep away from incompatible chemicals
Environmental Hazards: Not classified as marine pollutant
IMDG/IATA/ADR Information: Not subject to special transport requirements under major codes

Regulatory Information

OSHA Status: Not classified as hazardous chemical under US OSHA criteria
SARA Title III: Ingredient(s) not subject to reporting under Section 313
TSCA: Components listed in US TSCA inventory
REACH: Components either registered or exempt
WHMIS: Not a controlled product in Canada
EU Classification: Non-hazardous at intended use concentration, reference CLP/GHS standard
Labeling: Name, concentration, lot number, expiry, manufacturer, and recommended use displayed permanently on each container
Additional Notes: Suppliers and handlers must monitor for regulatory updates and adapt safety data sheets as required by law; professional judgment and adherence to local occupational health standards remain critical throughout the life cycle of the chemical