Product Name: Butorphanol Tartrate
Chemical Formula: C21H29NO2·C4H6O6
Synonyms: Butorphanol Hydrogen Tartrate
CAS Number: 58756-22-2
Intended Use: Pharmaceutical analgesic, veterinary applications
Supplier Details: Manufacturer or distributor contact information, including address, emergency contact phone number, and responsible department (Occupational Health/Safety or Logistics)
Classification: Acute Toxicity (Oral, Dermal, Inhalation), Eye and Skin Irritation, Specific Target Organ Toxicity (Central Nervous System, Respiratory Depression)
GHS Label Elements: Signal word “Danger”, hazard statements for potential respiratory depression, CNS effects, addiction risk
Pictograms: Skull and crossbones, health hazard, exclamation mark
Primary Hazards: May cause breathing difficulties, drowsiness, addiction; exposure through ingestion, skin absorption, or accidental injection considered extremely dangerous without appropriate controls
Symptoms of Exposure: Reduced consciousness, respiratory depression, confusion, pinpoint pupils, slow heart rate, possible euphoria followed by nausea or vomiting
Main Ingredient: Butorphanol Tartrate
Chemical Identity: 21-29% by weight of the active, with tartrate salt stabilizer
Impurities/Additives: Residual solvents, unreacted intermediates, trace levels of process chemicals (percentages or ranges provided by manufacturer)
Physical State: Solid crystalline powder; may be supplied for solution or injectable formulations
Concentration: Pharmaceutical preparations range from 1 to 10 mg/mL in solution, 10-40 mg/vial in veterinary uses
Inhalation: Move affected person to fresh air, keep at rest, monitor breathing, seek emergency medical attention for respiratory distress or signs of overdose
Skin Contact: Wash exposed area thoroughly with soap and water; remove contaminated clothing; seek medical attention if irritation or symptoms persist
Eye Contact: Rinse eyes immediately with plenty of water for at least 15 minutes; hold eyelids apart; consult medical personnel if irritation continues
Ingestion: Do not induce vomiting, rinse mouth, seek emergency healthcare; watch for respiratory depression, sedation, sudden unconsciousness
Overdose Symptoms: Shallow breathing, loss of consciousness, pinpoint pupils, slow heart rate—administer naloxone if available and call emergency services
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide extinguishers
Non-suitable Media: Direct streams of water (potential to spread powder or cause runoff contamination)
Fire Hazards: Combustion releases toxic fumes including nitrogen oxides, carbon monoxide, other hazardous decomposition products
Protective Equipment: Full fire-fighting turn-out gear, self-contained breathing apparatus, chemical-resistant gloves and boots
Special Instructions: Cool containers exposed to fire with water spray; avoid inhaling fumes; contaminated firefighting water should be contained, not released to sewers or public waterways
Personal Protection: Wear nitrile gloves, lab coat, safety goggles, NIOSH-approved respirator if dust or aerosol is generated
Environmental Precautions: Prevent entry into drains, waterways, soil; contain spill using absorbent materials appropriate for fine powders or liquid residues
Cleanup Methods: Vacuum (using HEPA filters), then wet-wipe surfaces with detergent and water; avoid dry sweeping that might re-aerosolize dust; collect cleanup residues for proper disposal as hazardous waste
Decontamination: Wash area with soapy water, ensure no residues remain
Handling: Use dedicated equipment and trained personnel; minimize dust and aerosol formation; maintain adequate ventilation and strict hygiene controls; avoid ingestion, inhalation, skin and eye contact
Storage Conditions: Keep in tightly sealed containers, protected from light, ideally in temperature-controlled conditions (2-8°C for solutions, denser storage for dry substances); store in secure area, restricted access for unauthorized personnel; labeled as controlled substance where required by law
Incompatibilities: Oxidizing agents, strong acids, or bases; incompatible with materials that increase risk of ignition or toxic degradation
Engineering Controls: Local exhaust ventilation, closed handling systems where available, fume hood for weighing or transferring powder
Exposure Limits: Occupational Exposure Limits (OELs) specific to butorphanol not universally established, but use nanogram per cubic meter range as prudent; refer to company or jurisdictional guidelines
Personal Protective Equipment (PPE): Double gloves (nitrile, latex for backup), disposable lab coats, safety glasses, face mask or respirator (P100 or equivalent) where powder or aerosols present
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing before eating, no smoking or eating in work areas, routine environmental cleaning protocols
Appearance: White to off-white crystalline powder
Odor: Practically odorless
Melting Point: 141-145°C (for tartrate salt)
Solubility: Soluble in water, slightly soluble in alcohol (1g dissolves in 2-4ml H2O); insoluble in ether or chloroform
Molecular Weight: 477.54 g/mol (tartrate salt)
pH: Slightly acidic in aqueous solution
Partition Coefficient (Log Kow): Not expected to accumulate in fat; logP about 2
Vapor Pressure: Not volatile at room temperature
Chemical Stability: Stable when stored under recommended conditions away from light, moisture, and excess heat
Decomposition: Thermal breakdown produces hazardous gases such as carbon monoxide, nitrogen oxides, possibly ammonia
Reactivity: Reacts with strong oxidizers or acids; avoid high temperature, light exposure, incompatible packaging
Polymerization: Not anticipated under normal use conditions
Routes of Exposure: Ingestion, inhalation, skin, mucous membrane, and accidental injection
Acute Toxicity Data: LD50 (oral, rat): ~50 mg/kg; possible severe toxic effects on central nervous system even at low doses for unmedicated humans
Chronic Effects: May cause dependence, constipation, mood changes, withdrawal if used repeatedly; long term exposure associated with risk of CNS suppression, respiratory effects
Mutagenicity/Carcinogenicity: No strong evidence in animal studies of carcinogenic or mutagenic properties, but not exhaustively studied in humans; animal data points to possible reproductive effects at high doses
Target Organs: CNS, respiratory system, gastrointestinal tract
Aquatic Toxicity: Not extensively studied, but opioids pose risks to aquatic species even at low concentrations; possible disruption of invertebrate hormonal signaling
Persistence and Degradability: Partially biodegradable in water and soil, but breakdown may produce bioactive intermediates
Bioaccumulative Potential: Low; unlikely to accumulate in aquatic life or in human food chain, rapid metabolic degradation in most animals
Mobility in Soil: Moderate solubility means risk of leaching into groundwater, particularly near medical waste or industrial sites
Product Disposal: Incinerate in approved medical waste facility; neutralize solutions with strong oxidants as per local hazardous waste programs; avoid release into environment or sewage system
Contaminated Packaging: Triple rinse, puncture, render packaging unusable, then dispose of as hazardous waste; label as pharmaceutical waste according to national or local rules
Regulatory Guidance: DEA controls in United States, special disposal procedures required due to schedule classification; follow local environmental control agency
UN Number: UN3249 (if classified as a toxic solid, organic, n.o.s.—check specific transport regulations)
Proper Shipping Name: Toxic Solid, Organic, n.o.s. (Butorphanol Tartrate)
Transport Hazard Classes: Class 6.1 (toxic substances)
Packing Group: II or III, depending on concentration
Special Precautions: Requires secure packaging, chain of custody documentation, controlled by law for import/export, must carry documentation for regulated transport
Environmental Hazards: Not a marine pollutant under IMDG Code
Additional Information: Transport only in original, labeled containers
Status: Controlled substance in many countries (Schedule IV in US federal law), subject to prescription and medical use controls; reporting for possession, use, transfer required in most jurisdictions
OSHA Status: Regulated as hazardous drug, requires worker safety plans for handling, storage, and disposal
TSCA (Toxic Substance Control Act): Not listed for use outside pharmaceutical or research contexts
Other Regulations: IATA/IMDG for shipping, EPA/RCRA for hazardous disposal, DEA for security and tracking in US
Labeling: Must include hazard statements, risk/safety phrases, emergency contact information, and any national identification or control numbers
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