Product Name: Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate
SYNONYMS: Cyclophosphamide Monohydrate, Endoxan Hydrate, Cytoxan Monohydrate
CAS Number: 6055-19-2
Manufacturer: Contact reputable chemical manufacturer for specific details
Recommended Uses: Research, laboratory applications, manufacturing of pharmaceuticals
Emergency Phone: Refer to certified safety data server or local poison control hotline
Address: Available through supplier site identification
Classification: Acute toxicity, carcinogenicity, mutagenicity, reproductive toxicity, specific target organ toxicity
Signal Word: Danger
Hazard Statements: Causes serious eye and skin irritation, toxic if swallowed, suspected of causing cancer, may damage fertility, may cause genetic defects, toxic to aquatic organisms
Pictograms: Skull and crossbones, health hazard, corrosion, exclamation mark
Potential Health Effects: Exposure through inhalation, ingestion, or skin contact can result in nausea, immunosuppression, organ damage, and changes to DNA. High risk of cancer after chronic exposure.
Precautionary Statements: Avoid inhaling dust or vapor, wear PPE, wash hands after handling, do not eat or drink near product, store in well-ventilated and locked facility.
Chemical Name: Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate
Molecular Formula: C7H15Cl2N2O2P•H2O
Content: >98% pure active ingredient, trace water, less than 0.1% uncharacterized impurities
Impurities: Unspecified organic and inorganic traces as residual solvents or process byproducts
Other Components: None identified above regulatory thresholds
Inhalation: Remove victim to fresh air, keep comfortable, provide oxygen if breathing is difficult, seek immediate medical attention
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with soap and water for at least 15 minutes, seek medical advice for irritation or burns
Eye Contact: Rinse eyes with water for several minutes, remove contact lenses if present, continue flushing and get medical attention urgently
Ingestion: Do not induce vomiting, rinse mouth, drink water only if conscious, transport to medical center immediately
Medical Attention: Provide safety data sheet to attending doctor, monitor for delayed symptoms, treat symptomatically for organ-specific toxicity
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, water spray
Specific Hazards: Releases toxic fumes including phosphorous oxides, nitrogen oxides, hydrogen chloride, and carbon oxides under fire conditions
Protective Equipment: Use self-contained breathing apparatus, full protective clothing
Firefighting Procedures: Move containers from fire if safe, cool exposed containers with water spray, prevent runoff to drains or waterways
Explosion Hazard: No reported explosion risk, but emits hazardous decomposition products in presence of heat
Personal Precautions: Evacuate unprotected personnel, wear protective clothing, gloves, goggles, respirator
Environmental Precautions: Prevent product from entering drains, watercourses, or soil
Clean-up Procedures: Ventilate area, absorb spill with inert material such as vermiculite, transfer to chemical waste container, wash area with water and detergent, avoid dry sweeping to prevent aerosol mist
Disposal: Place disposed material in labeled, approved chemical waste containers for proper incineration
Handling: Handle in chemical fume hood, avoid dust formation, minimize exposure, avoid contact with skin and eyes, do not breathe dust or vapor, prevent ingestion
Storage Conditions: Store locked in secure chemical storage, out of reach of unauthorized personnel, temperature range 2-8°C, in original tightly-sealed packaging, segregate from incompatible compounds such as strong bases, oxidizers, acids, and reducing agents, keep away from direct sunlight, humidity, and heat sources
Incompatible Materials: Strong oxidizing agents, acids, bases, reducing agents, moisture
Exposure Limits: OSHA PEL not established, NIOSH REL not assigned, occupational protection essential
Engineering Controls: Use certified chemical fume hood, local exhaust ventilation, splash-proof safety eyewash, and shower station nearby
Personal Protective Equipment: NIOSH approved respirator, chemical resistant gloves (nitrile/butyl), safety goggles, lab coat, full-length clothing, closed shoes
Hygiene Precautions: Wash hands thoroughly after handling, do not bring contaminated materials home, avoid exposure to pregnant individuals
Environmental Controls: Closed system transfer and containment practices, air monitoring for workplace contamination, avoid release to drains
Appearance: White to off-white crystalline powder
Odor: Slight, characteristic chemical odor
Odor Threshold: Not available
pH (aqueous solution): 4-7
Melting Point: 50-52°C (decomposes)
Boiling Point: Data not available
Flash Point: Not applicable (decomposes before boiling)
Evaporation Rate: Not determined
Flammability: Not flammable
Vapor Pressure: Very low at room temperature
Vapor Density: Not determined
Relative Density: 1.3 g/cm³
Solubility: Freely soluble in water, soluble in ethanol, slightly soluble in acetone
Partition Coefficient (log Pow): 0.6–0.78 (approximate)
Auto-ignition Temperature: Not self-igniting
Decomposition Temperature: 50-52°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage and normal handling conditions, breaks down if heated above decomposition temperature or exposed to strong acids/bases
Reactivity: Can react violently with strong oxidizing agents, strong acids, and bases
Hazardous Reactions: May hydrolyze in presence of water, releases corrosive and toxic gases on decomposition
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, phosphorus oxides, hydrogen chloride, nitrogen oxides, and other hazardous vapors
Incompatible Materials: Acid chlorides, anhydrides, oxidizing reagents, strong bases, water/moisture
Acute Toxicity: Highly toxic by oral, dermal, or inhalation routes, LD50 (oral, rat): 200–400 mg/kg
Chronic Effects: Chronic exposure increases cancer risk, causes mutagenic effects, infertility, immune suppression
Carcinogenicity: Listed as human carcinogen by IARC, NTP, OSHA
Mutagenicity: Causes mutations in laboratory tests
Reproductive Toxicity: Can impair fertility and cause birth defects
Sensitization: Possible skin and respiratory tract sensitizer
Symptoms of Exposure: Nausea, vomiting, diarrhea, skin rash, bone marrow suppression, immunosuppression, hair loss, mouth ulcers
Target Organs: Bone marrow, immune system, liver, reproductive organs, kidneys, bladder
Ecotoxicity: Harmful to aquatic life even at low concentrations, acute aquatic LC50 (fish, daphnia): Low mg/L range
Persistence: Not readily biodegradable, may persist in the environment
Bioaccumulation: Expected to have low potential for bioaccumulation, but metabolites may accumulate
Mobility: High water solubility raises risk of groundwater contamination
Other Adverse Effects: Toxic transformation products can form in the environment, avoid discharge to environment
Disposal Methods: Incinerate in a chemical incinerator outfitted with afterburner and scrubber, follow all local, regional, and national regulations
Contaminated Packaging: Dispose of as unused product, use puncture-proof, sealed, labeled containers, decontaminate with bleach solution if permitted
Special Precautions: Work with registered hazardous waste disposal providers familiar with cytotoxic substances, retain documentation
Prevention: Limit waste generation through careful inventory control and process design
UN Number: UN2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
DOT, IMDG, IATA: Classified as a dangerous good, packaging should meet regulatory requirements, include hazard communication labels
Special Precautions: Avoid damage, follow spill/leak procedure, do not load with food or animal feed, transport documentation must accompany shipment
OSHA: Subject to Hazard Communication Standard, listed as hazardous chemical
TSCA: Listed or regulated, check substance list for current status
SARA Title III: Requires reporting under specific conditions for toxic release inventory
RCRA: Considered hazardous waste under U.S. guidelines, must comply with disposal requirements
California Proposition 65: Listed as causing cancer and reproductive toxicity
International Regulations: Covered under REACH (EU), WHMIS (Canada), international transport guidelines applicable
Additional Requirements: Retain safety data sheets, provide employee training, notify authorities of significant releases
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