Product Name: A-3-(2-(7-Chloro-2-Quinolinyl)Ethenyl)Phenyl-2-(1-Hydroxy-1-Methylethyl)-(R-(E))-Benzenepropanol
SYNONYMS: Montelukast Intermediate
CAS Number: [Contact supplier for accurate CAS]
Recommended Use: Synthesis intermediate in the production of Montelukast
Supplier: [Insert laboratory or manufacturer name with full address, telephone, emergency contact]
Emergency Telephone: [Insert specific number for immediate chemical emergency response, such as CHEMTREC or local poison control]
GHS Classification: Acute toxicity (oral), Skin irritation, Eye irritation, Specific target organ toxicity (single and repeated exposure)
Pictograms: Exclamation mark, health hazard symbol
Signal Word: Warning
Hazard Statements: May be harmful if swallowed. Causes moderate skin irritation. Causes moderate eye irritation. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: Wear protective gloves/protective clothing/eye protection/face protection. Wash hands thoroughly after handling. Avoid breathing dust/fume/gas/mist/vapors/spray. Do not eat, drink or smoke when using the product.
Chemical Name: A-3-(2-(7-Chloro-2-Quinolinyl)Ethenyl)Phenyl-2-(1-Hydroxy-1-Methylethyl)-(R-(E))-Benzenepropanol
Concentration: >95% pure
Impurities: Minor process impurities (<5%) related to synthetic pathway
Molecular Formula: C26H23ClNO2
Molecular Weight: 415.92 g/mol
Inhalation: Move person to fresh air. Seek immediate medical attention if symptoms develop such as difficulty breathing, chest tightness, or persistent cough.
Skin Contact: Remove contaminated clothing and wash affected area thoroughly with soap and water. If irritation or redness occurs and persists, see a physician.
Eye Contact: Rinse eyes cautiously with water for at least fifteen minutes, lifting eyelids occasionally. Remove contact lenses if present and easy to do. Obtain medical attention if irritation continues.
Ingestion: If swallowed, do not induce vomiting. Rinse mouth with water and seek medical help promptly, reporting the nature of the compound for proper treatment.
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam. Avoid straight water streams as the chemical may spread.
Specific Hazards: During fire, toxic fumes such as hydrogen chloride, nitrogen oxides, and possibly carbon monoxide may develop.
Protective Equipment: Firefighters require positive-pressure self-contained breathing apparatus and complete protective suit.
Special Procedures: Cool containers exposed to fire with water mist to minimize the risk of rupture. Prevent run-off from entering water systems or sewers.
Personal Precautions: Avoid inhalation of dusts, vapors, or aerosols. Use personal protective equipment such as gloves, goggles, mask, and protective clothing.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Discharge into the environment must be avoided. Small spills: Sweep up or vacuum and transfer to a closed container. Wet down to minimize dust generation.
Cleanup Methods: Collect and place in adequately labeled containers for disposal according to local regulations. Ventilate the area thoroughly and wash spill site after material pickup is complete.
Handling: Wear proper personal protective equipment. Avoid contact with eyes, skin, and clothing. Avoid generating dust or breathing vapors or aerosols. Practice good chemical hygiene and wash hands after handling.
Storage: Keep tightly closed in a cool, dry, well-ventilated area away from incompatible materials such as oxidizers and strong acids. Protect from direct sunlight, heat, and moisture. Store at recommended temperature indicated by supplier, usually between 2–8°C.
Exposure Limits: No specific occupational exposure limits established at this time; minimize exposure as far as possible.
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits.
Personal Protective Equipment: Gloves resistant to chemicals, chemical splash goggles, lab coats or protective clothing, approved respirator when airborne concentrations are excessive.
Hygiene Measures: Avoid eating, drinking, and smoking in the work area. Wash hands before breaks and at end of work.
Appearance: Off-white to yellowish crystalline solid
Odor: Faint, chemical
Odor Threshold: Data not established
pH: Not applicable (insoluble in water)
Melting Point: 142–148°C (approximate range, check analytical protocol for precise value)
Boiling Point: Not available
Flash Point: >150°C
Flammability: Not highly flammable under normal handling conditions
Vapor Pressure: Data not available
Solubility: Soluble in organic solvents such as DMSO, ethanol; very low solubility in water
Density: Approximately 1.2–1.4 g/cm³
Partition Coefficient (log Kow): Data not available
Decomposition Temperature: Not available
Viscosity: Not applicable (solid at room temperature)
Chemical Stability: Stable under recommended storage conditions and normal handling
Incompatible Materials: Strong oxidant agents, strong acids, and strong bases may cause exothermic reactions or degrade compound
Hazardous Decomposition Products: Fumes of carbon monoxide, carbon dioxide, hydrogen chloride, nitrogen oxides on combustion or thermal decomposition
Polymerization: No hazardous polymerization expected.
Conditions to Avoid: Strong heat, open flames, moisture, and exposure to direct sunlight. Prevent contact with incompatible chemicals.
Acute Toxicity: Not fully tested on this compound. Similar compounds show mild to moderate acute toxicity if inhaled, ingested, or in contact with skin.
Skin Corrosion/Irritation: May cause moderate irritation based on component structure and similar compounds.
Serious Eye Damage/Irritation: May result in redness, tearing, and discomfort.
Respiratory or Skin Sensitization: Not known to cause sensitization, but avoid repeated and prolonged contact.
Chronic Toxicity: Prolonged exposure may cause effects to target organs, including liver and kidneys, based on related compounds.
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified as carcinogenic, mutagenic, or reproductive toxicant based on current data, although testing is incomplete.
Symptoms of Exposure: Nausea, headache, skin irritation, respiratory irritation possible in poorly ventilated conditions.
Ecotoxicity: Data not sufficient for definitive classification, but related aromatic compounds and quinoline structures show moderate persistence and toxicity in aquatic environments.
Persistence and Biodegradability: Degradation in the environment is likely to be slow. May be persistent in soil and water.
Bioaccumulative Potential: High in aquatic species is possible based on the compound’s lipid solubility.
Mobility in Soil: Likely low as the compound is relatively insoluble in water and tends to adsorb onto the soil.
Other Adverse Effects: Letting this compound enter water systems can harm aquatic life, so avoid uncontrolled discharge.
Waste Treatment Methods: Dispose of as hazardous chemical waste according to local, regional, and national regulations.
Incineration: Send to a chemical incinerator equipped with afterburner and scrubber.
Container Disposal: Completely empty containers should be triple-rinsed and disposed of as hazardous waste or recycled where permitted.
Special Precautions: Do not discharge into sewers, surface water, or soil. Always consult with environmental authorities before disposal to ensure safe and compliant handling.
UN Number: Not classified as hazardous for transport under most international transport regulations
UN Proper Shipping Name: Not regulated
Transport Hazard Class: None applicable
Packing Group: None applicable
Environmental Hazards: Not listed as a marine pollutant; precautions needed to avoid accidental spillage
Special Precautions for Transport: Protect containers from physical damage, exposure to temperature extremes, and secure load to prevent movement.
International Regulations: Not listed under major chemical regulatory lists such as IARC, NTP, ACGIH as hazardous or carcinogenic
European Union (REACH): Check if supplier has registered the substance or requires notification
United States (TSCA): Confirm status for use and handling in accordance with federal regulations
Other Regulatory Lists: Ensure compliance with local and national environmental and occupational health authorities
Labeling: Follow GHS and country-specific labeling requirements with accurate hazard statements and handling advice visible on shipping and storage containers.
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