Product Name: 5'-Noranhydrovinblastine Tartrate
Synonyms: Norvinblastine bitartrate, Vinca alkaloid derivative
Chemical Formula: C46H58N4O9·C4H6O6
Molecular Weight: 963.07 g/mol
Recommended Use: Research chemical; investigational compound
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CAS Number: 117896-45-6
UN Number: Not regulated
REACH Registration Number: Not applicable for research sample quantities
Classification: Toxic if swallowed, suspected of causing cancer, may damage fertility, may cause genetic defects, hazardous to the aquatic environment
Hazard Symbols: Skull and crossbones, exclamation mark, health hazard, aquatic toxicity
Signal Word: Danger
Hazard Statements: May cause serious health effects if inhaled, swallowed, or in contact with skin. May irritate eyes and respiratory tract. Suspected of reproductive toxicity. Harmful to aquatic life with long-lasting effects.
Precautionary Statements: Avoid breathing dust. Wear chemical-resistant gloves, protective clothing, and eye/face protection. Wash exposed area thoroughly after handling. Avoid release to the environment. Seek medical attention if exposed or if symptoms occur.
Chemical Name: 5'-Noranhydrovinblastine Tartrate
Concentration: >95% (w/w)
CAS Number: 117896-45-6
Impurities: Trace related vinca alkaloids (<5%)
Stabilizers/Additives: None reported
Mixture: Single active ingredient in tartrate salt form
Inhalation: Move to fresh air. Keep individual at rest. If not breathing, provide artificial respiration. Seek immediate medical assistance.
Skin Contact: Remove contaminated clothing. Immediately wash skin with copious amounts of soap and water. If irritation or rash persists, get medical attention.
Eye Contact: Immediately flush eyes with plenty of water for at least 15 minutes, lifting upper and lower eyelids occasionally. Remove contact lenses if safe and easy. Seek prompt medical care.
Ingestion: Rinse mouth thoroughly with water, do not induce vomiting unless directed by medical personnel. Never give anything by mouth to an unconscious person. Seek immediate medical help.
Important Symptoms: Nausea, vomiting, dizziness, headache, abdominal pain, hematological effects, difficulty breathing if large inhaled dose.
Note to Physician: Treat symptomatically, monitor for bone marrow suppression or neurological effects.
Extinguishing Media: Use water spray, alcohol-resistant foam, carbon dioxide, or dry chemical.
Unsuitable Media: Direct water jet may spread material.
Special Hazards: May emit toxic fumes such as nitrogen oxides and carbon oxides under fire conditions.
Protective Equipment: Wear full protective gear including self-contained breathing apparatus.
Firefighting Instructions: Evacuate personnel to safe area, approach upwind, prevent run-off from entering drains, cool containers with water spray to prevent pressure build-up.
Explosion Risk: Does not present an explosion hazard in powder form; avoid dust clouds.
Personal Protection: Use personal protective equipment specified in section on exposure controls. Keep unprotected persons away.
Spill Response: Avoid creating dust. Scoop up spilled material using tools that do not generate dust. Dampen materials with wet absorbent if needed.
Cleanup Methods: Clean area thoroughly after pickup. Dispose in sealed, labeled containers. Use HEPA-filtered vacuum for fine particles.
Environmental Precautions: Prevent further leakage or spillage if safe to do so. Avoid release to the environment, especially water sources.
Notification: Inform relevant authorities in line with local regulations if large amounts enter watercourses or public drainage.
Safe Handling: Handle in a certified chemical fume hood to prevent inhalation. Avoid exposure to dust, do not ingest. Wear appropriate personal protective equipment. Keep container tightly sealed.
Hygiene Practices: Wash hands and face thoroughly after use; avoid eating, drinking, or smoking in work area.
Storage Conditions: Store in original container, tightly closed, in a cool, dry, well-ventilated area away from direct light.
Incompatibilities: Oxidizing materials, strong acids, strong bases.
Packaging Materials: Use high-density polyethylene or glass containers.
Storage Temperature: Recommended 2–8°C, do not freeze.
Occupational Exposure Limits: No specific OSHA or ACGIH values; treat as hazardous on skin and via inhalation.
Engineering Controls: Work with local exhaust ventilation. Use chemical fume hood or glove box for open handling.
Personal Protective Equipment: Chemical-resistant gloves (nitrile recommended), lab coat or gown, safety goggles, and respiratory protection (P3 particulate filter or equivalent) if inhalation risk exists.
Environmental Controls: Prevent dispersion of dust; use closed systems for weighing and transfer.
Hygiene Measures: Remove personal protective equipment and wash hands before leaving laboratory. Decontaminate work surfaces after use.
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not determined
pH (Aqueous Solution): 3.5–4.5 (1% solution)
Melting Point/Range: 238–241°C (decomposes)
Boiling Point: Not available (decomposes before boiling)
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not flammable
Vapor Pressure: Not applicable (non-volatile solid)
Vapor Density: Not applicable
Relative Density: 1.48 g/cm³ (estimated)
Solubility: Soluble in water, ethanol, and DMSO
Partition Coefficient (log Kow): Not determined
Autoignition Temperature: Not available
Decomposition Temperature: Above 238°C
Viscosity: Not applicable
Chemical Stability: Stable under normal laboratory conditions, away from moisture, heat, and direct sunlight.
Reactivity: Non-reactive with most common laboratory reagents under normal conditions.
Conditions to Avoid: Excessive heat, incompatible chemicals, direct sunlight.
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases.
Hazardous Decomposition Products: On combustion or degradation, can produce toxic gases including nitrogen oxides and carbon monoxide.
Polymerization: Will not occur.
Acute Toxicity: Data limited; expected to be highly toxic based on related alkaloids (venous access accidental injection toxic at low doses). Oral rat LD50 estimated <10 mg/kg.
Skin Corrosion/Irritation: May cause local irritation after contact.
Eye Damage/Irritation: Risk of conjunctival and corneal damage from direct exposure.
Inhalation: Inhalation of dust may cause coughing, respiratory irritation, systemic toxicity.
Sensitization: Not determined; treat as potential sensitizer.
Chronic Toxicity: Repeat or prolonged exposure may cause bone marrow suppression, neurotoxicity, reproductive hazards, teratogenicity, carcinogenicity based on class.
Germ Cell Mutagenicity: Evidence from vinca alkaloids and analogs demonstrates potential mutagenic risk.
Carcinogenicity: Not classified for this specific compound; structural similarity to agents with known or suspected carcinogenic potential.
Reproductive Toxicity: Animal studies with related compounds show embryotoxic and fetotoxic effects.
Target Organs: Bone marrow, nervous system, gastrointestinal tract.
Ecotoxicity: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
Persistence and Degradability: Limited information available; complex molecular structure implies slow degradation in natural environments.
Bioaccumulation: Potential for bioaccumulation is not well studied; structurally similar compounds tend not to bioaccumulate significantly.
Mobility in Soil: Predicted low mobility owing to low volatility and moderate water solubility.
Other Adverse Effects: Avoid uncontrolled environmental exposure. No significant photodegradation expected in environment.
Waste Treatment Methods: Collect and dispose of in accordance with local, regional, and national regulations for pharmaceutical hazardous waste.
Contaminated Packaging: Dispose of as unused product; do not reuse packaging materials.
Sewage Disposal: Do not flush to drain, sewers, or water bodies.
Recommended Disposal: Use licensed chemical waste contractor; incineration preferred if permissible with afterburner and scrubber.
Special Precautions: Personnel handling disposal should use full personal protective equipment; decontaminate area after spill or packaging breakage.
UN Number: Not regulated for transport unless in bulk or high-concentration forms.
UN Proper Shipping Name: Not classified
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant in available quantities; avoid releases during transport.
Special Precautions: Store in secure, clearly labeled containers;
Transport in Bulk: Not recommended; transport in tightly closed original containers within secondary containment.
US Regulation: Not listed on the US TSCA Inventory; for research and investigational use only. Not assigned a CERCLA reportable quantity or SARA Title III hazard classification.
EU Classification: Not classified under EC 1272/2008, but treat as toxic for handling under local regulations.
Other National Regulations: Use in compliance with workplace exposure limits and hazardous substance controls where available.
Labeling Requirements: Labels should include chemical name, hazard pictograms, hazard and precautionary statements per GHS.
Inventory Status: Not found on major global chemical inventories such as DSL, NDSL, EINECS or AICS.
Workplace Control: Risk assessment recommended under national occupational safety and health guidelines.
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