Material Safety Data Sheet: 4-Hydroxy-4'-chloro-benzophenone

Identification

Product Name: 4-Hydroxy-4'-chloro-benzophenone
Chemical Formula: C13H9ClO2
SYNONYMS: 4'-Chloro-4-hydroxybenzophenone, p-Hydroxy-p'-chlorobenzophenone
CAS Number: 611-99-4
Recommended Use: Laboratory reagent, intermediate for synthesis
Manufacturer/Supplier: [Supplier Name], [Supplier Address], [Supplier Telephone]
Emergency Contact: [Emergency Number]

Hazard Identification

Classification: Irritant to skin and eyes, toxic by ingestion, environmental hazard
Hazard Statements: Causes serious eye irritation, may cause respiratory irritation, harmful if swallowed
Pictograms: Exclamation mark, Environment
Precautionary Statements: Avoid breathing dust, wear protective gloves and goggles, wash thoroughly after handling, do not eat or drink when using
Signal Word: Warning

Composition / Information on Ingredients

Chemical Name: 4-Hydroxy-4'-chloro-benzophenone
Concentration: ≥99% (pure substance)
Additives: No added stabilizers or diluents
Impurities: Trace organic and inorganic compounds <1%

First Aid Measures

Inhalation: Move to fresh air, support breathing as needed, seek medical attention for persistent symptoms
Skin Contact: Remove contaminated clothing, wash thoroughly with soap and water, contact a doctor if irritation occurs
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, lift eyelids periodically, get medical evaluation quickly
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical advice, show doctor safety data sheet
Most Important Symptoms: Eye redness, skin irritation, throat discomfort if inhaled, stomach upset if ingested

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray for larger fires
Hazardous Combustion Products: Hydrogen chloride, carbon monoxide, carbon dioxide, irritating fumes
Protective Equipment for Firefighters: Full protective suit, self-contained breathing apparatus
Special Fire Fighting Procedures: Use water spray to cool containers, avoid direct water stream on powder to prevent spread
Unusual Fire Hazards: Dust can ignite under strong heat; toxic fumes may accumulate in fire conditions

Accidental Release Measures

Personal Precautions: Wear gloves, goggles, dust mask or respirator, avoid breathing in dust, stay upwind
Environmental Precautions: Prevent material from entering drains, waterways, or soil
Cleanup Methods: Sweep up material carefully, place in a secure container for disposal, wash area with water, ventilate space
Containment: Use barriers or mats to limit spread, remove ignition sources
Decontamination: Clean affected area with soapy water, discard contaminated materials properly

Handling and Storage

Safe Handling Advice: Minimize dust generation, use in a well-ventilated space, do not eat or drink near material, wash hands and exposed skin after handling
Storage Requirements: Store in tightly closed container, in a dry, cool, and well-ventilated place, away from direct sunlight, heat, and incompatible substances such as strong acids and bases
Storage Class: Chemical store, away from food and incompatible materials
Transfer Precautions: Use tools or scoops; do not use bare hands or inhale directly above material
Incompatibilities: Oxidizing agents, strong acids and bases

Exposure Controls and Personal Protection

Occupational Exposure Limits: Not established for this chemical, use general dust exposure limits (<1 mg/m³)
Engineering Controls: Local exhaust ventilation, safety shower and eyewash stations easily accessible
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles or face shield, laboratory coat or chemical apron, dust mask or NIOSH-approved respirator when airborne dust present
Hygiene Measures: Remove contaminated clothing immediately, do not touch face or eyes during handling, wash hands thoroughly after use

Physical and Chemical Properties

Appearance: Off-white to pale yellow crystalline powder
Odor: Faint, phenolic odor
Molecular Weight: 232.66 g/mol
Melting Point: 173–176°C
Boiling Point: Not available
Solubility: Slightly soluble in water, soluble in alcohol and organic solvents
Density: Approximately 1.36 g/cm³
Vapor Pressure: Negligible at room temperature
pH: Not applicable
Flash Point: >200°C
Flammability: Not classified as flammable solid
Partition Coefficient (log Kow): Estimated at 3.4

Stability and Reactivity

Chemical Stability: Stable under typical conditions, avoid excessive heat and moisture
Possibility of Hazardous Reactions: No hazardous polymerization, reacts with strong acids/bases
Conditions to Avoid: Heat, direct sunlight, static discharge, sparks
Incompatible Materials: Strong oxidizers, strong acids or bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen chloride, toxic organic vapors

Toxicological Information

Acute Toxicity: Oral, rat LD50 estimated >2000 mg/kg (low acute toxicity)
Skin Corrosion/Irritation: Causes skin irritation
Serious Eye Damage/Irritation: Risk of serious eye irritation
Respiratory Sensitization: Inbreathing dust may irritate respiratory tract
Carcinogenicity: Not listed by IARC, NTP, or OSHA as carcinogen
Mutagenicity: No mutagenic effects observed in major studies
Other Effects: May cause allergic skin reaction for sensitive individuals

Ecological Information

Aquatic Toxicity: Harmful to aquatic life with long lasting effects
Persistence and Degradability: Limited biodegradability, may persist in environment
Bioaccumulation Potential: Potential for bioaccumulation due to log Kow value
Mobility in Soil: Low water solubility suggests limited mobility
Other Environmental Information: Avoid release to environment, collect spillage and dispose responsibly

Disposal Considerations

Disposal Methods: Dispose of as hazardous chemical waste according to local, regional, and national regulations
Contaminated Packaging: Triple rinse containers and dispose with chemical waste
Special Precautions: Do not dump in sewer, drains, or natural bodies of water, transfer all residues to secure hazardous waste facility
Recommended Waste Codes: EWC: 07 07 08 (other organic chemicals)

Transport Information

UN Number: Not regulated under most international transport regulations
Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Special Precautions: Protect package from physical damage and avoid extreme conditions, keep tightly closed during transit

Regulatory Information

Safety, Health and Environmental Regulations: Not specifically listed under US TSCA, EU REACH Annex SVHC, or other global chemical inventories
OSHA Hazards: Irritant
EPA Regulations: Not designated as hazardous waste, follow local environmental requirements for disposal
Label Requirements: Comply with workplace labeling, hazard communication standards
Other Regulatory Notes: Users should ensure compliance with local workplace safety and environmental rules; handle in accordance with best laboratory and industrial hygiene practices