Product Name: 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate
Synonyms: DFDNV Ditartrate, Vinblastine analog ditartrate, Antineoplastic alkaloid derivative
CAS Number: 97396-79-7
Intended Use: Research and pharmaceutical applications as an antineoplastic agent
Manufacturer: Scientific laboratories specializing in oncology compounds
Contact Information: Chemical safety officer or laboratory supervisor phone number and email address
Emergency Phone: Regional poison control center or chemical emergency response
Molecular Formula: C44H54F2N4O10·C4H6O6
Molecular Weight: 1084.04 g/mol (free base plus ditartrate)
GHS Classification: Acute Toxicity (Oral, Dermal), Category 3; Eye Irritation, Category 2; Specific Target Organ Toxicity, Single Exposure, Category 2
Signal Word: Danger
Hazard Symbols: Skull and Crossbones, Exclamation Mark, Health Hazard
Hazard Statements: Toxic if swallowed or above certain dermal/inhalation thresholds; may cause eye irritation and breathing difficulties if dust is produced; possible mutagenic and carcinogenic risks from chronic exposure as determined in animal studies
Precautionary Statements: Avoid all direct contact; do not breathe dust or vapor; wash exposed skin thoroughly after handling; do not eat, drink, or smoke during use; dispose of waste safely
Routes of Exposure: Ingestion, skin contact, inhalation, eye contact
Effects of Overexposure: Nausea, vomiting, reduced white blood cell count, neurotoxicity, gastrointestinal upset, and possible organ damage after prolonged exposure, based on similar vinca alkaloids
Target Organs: Bone marrow, gastrointestinal tract, nervous system
Chemical Name: 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate
Concentration: >98% (by weight)
Other Components: Tartrate counterion as ditartrate salt
Impurities: Trace synthetic precursor compounds below detectable limits
CAS Registry Number: 97396-79-7
EC Number: Not listed due to novel research compound status
Ingredient Hazard Status: Main alkaloid demonstrates cytotoxicity in vitro and in vivo; ditartrate is not considered hazardous at included concentrations
General: Remove affected individual from exposure source; seek immediate medical attention for symptoms
Inhalation: Move to fresh air quickly; monitor breathing and provide oxygen as needed; seek medical evaluation
Skin Contact: Wash affected area with soap and copious amounts of water; remove contaminated clothing; medical evaluation if rash, blistering, or symptoms develop
Eye Contact: Flush eyes gently but thoroughly with water for at least 15 minutes holding eyelids apart; contact healthcare provider promptly
Ingestion: Rinse mouth thoroughly with water if patient is conscious; never give anything by mouth if unconscious; call poison control and physician without delay
Most Important Symptoms: Acute toxicity, immune suppression, skin or eye burns, systemic effects such as numbness or confusion
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, foam for larger fires involving packaging or bulk storage
Special Hazards: Product is not highly flammable, but combustion can release toxic fumes of carbon oxides, nitrogen oxides, and hydrogen fluoride
Protective Equipment: Firefighters should wear full protective clothing including self-contained breathing apparatus (SCBA) in enclosed spaces; avoid inhaling smoke
Specific Hazards: Most danger comes from inhaling decomposition products during fires; dust from thermal breakdown may linger in air
Advice for Firefighters: Cool containers with water if exposed to flames; avoid direct runoff from firefighting entering water supplies
Personal Precautions: Evacuate area, restrict access, ensure adequate ventilation; use certified chemical gloves, safety goggles, disposable lab coats, and NIOSH-approved masks
Spill Containment: Prevent particle spread by dampening powder before collection; do not let spilled material enter drains
Cleanup Procedure: Scoop spilled solid into chemical waste container; wipe surfaces with compatible disinfectant or soapy water; bag contaminated material for approved incineration
Decontamination: Double-bag all towels and PPE in heavy plastic bags labeled as cytotoxic waste
Environmental Protection: Avoid floor drains, open soil, or sewers; alert authorities if large spill enters water or earth
Safe Handling: Always handle in a functionally ventilated area, ideally in a certified chemical fume hood; wear full PPE; avoid dust formation and direct contact; do not pipette by mouth or eat in lab
Hygiene Measures: Wash hands and face after handling; change out of work clothes before leaving laboratory area
Storage Requirements: Store in tightly-closed original container at 2–8°C in a dry, well-ventilated area, securely locked or in designated hazardous chemical cabinets
Incompatible Materials: Strong oxidizers, strong acids or bases
Special Instructions: Label storage location clearly; restrict access to authorized, trained staff only; keep away from direct sunlight and sources of ignition
Container Materials: Use only glass, high-grade polyethylene, or polypropylene bottles, secured with chemical-resistant caps
Exposure Limits: No established occupational exposure limits; minimize all exposure as a precaution for cytotoxic agents
Engineering Controls: Chemical fume hood or biosafety cabinet at all times; local exhaust ventilation preferred in all manipulation areas
Personal Protective Equipment: Nitrile or double latex gloves, chemical splash goggles, full-length disposable lab coats or Tyvek-style overalls, closed-toe shoes
Respiratory Protection: NIOSH-approved respirator if dust or aerosol is present; P100 or HEPA filters for powder handling
Hand Protection: Double gloves in contact scenarios; replace gloves frequently
Eye/Face Protection: Safety goggles with side shields or face shield for high-risk procedures
Other Controls: Maintain clean work practices; use single-use items where feasible to reduce spread or exposure
Appearance: Off-white to pale yellow crystalline powder
Odor: No detectable odor
pH: Neutral in aqueous solution
Melting Point: About 162–167°C (decomposes)
Boiling Point: Not readily measurable; decomposes before boiling
Solubility: Soluble in methanol, DMSO, and water (as ditartrate)
Vapor Pressure: Negligible under recommended storage conditions
Flammability: Not easily flammable
Partition Coefficient: Data unavailable for compound; parent molecules have logP values in moderate hydrophilic range
Relative Density: Around 1.4 (estimated)
Stability: Stable under recommended storage conditions, decomposes with prolonged light or heat exposure
Chemical Stability: Stable at ambient temperatures and humidity; degrade under extremes of heat, light, or strong acids/bases
Hazardous Reactions: No dangerous polymerization or explosive reactions; sensitive to strong oxidizing or reducing agents
Conditions to Avoid: Prolonged exposure to sunlight, high temperatures, open flame, and wet conditions
Incompatible Materials: Strong oxidants (e.g., peroxides), strong acids/bases, reducing agents
Decomposition Products: Toxic fumes containing CO, CO2, HF, and nitrogen oxides when heated to decomposition
Reactivity Notes: Reacts as a weak organic base in presence of strong acids, but with low inherent hazard during controlled handling
Acute Toxicity: Oral and dermal toxicity in animal models prove high with LD50 below 10 mg/kg in rodents; data from structurally similar vinca alkaloids.
Chronic Toxicity: Prolonged low-dose exposure demonstrates leukopenia, bone marrow suppression, and possible cumulative neurotoxicity in mammalian subjects
Carcinogenic Potential: Evidence from in vitro studies suggests genotoxic activity, though no long-term animal or human studies yet confirm carcinogenicity
Mutagenicity: Increases chromosomal aberrations in cell cultures
Teratogenicity: Risks to embryonic/fetal development reported for related antineoplastic alkaloids; avoid use during pregnancy or with parenthood plans
Additional Information: No epidemiological data due to restricted research-only compound status. Monitor handlers for skin and hematological changes if working with bulk material.
Ecotoxicity: Cytotoxic to aquatic organisms; similar compounds disrupt algal growth, plankton viability, and aquatic invertebrates in low concentrations
Persistence and Degradability: Likely low biodegradability in soil and aquatic systems; may persist in the environment if released as solid or aqueous waste
Bioaccumulation Potential: Moderate risk of trophic transfer in aquatic food chains if not properly contained
Mobility in Soil: Compound may travel in water systems as soluble salt; risk of reaching groundwater
Other Adverse Effects: No data available for ozone depletion or photochemical smog generation; potential secondary toxicity in non-target species through improper disposal
Waste Treatment Methods: Incinerate all residues in accordance with local, state, and federal regulations for cytotoxic pharmaceuticals
Contaminated Packaging: Triple-rinse and incinerate, or treat as hazardous pharmaceutical waste
Special Precautions: Do not dispose of via landfill or municipal sewers; segregate from general laboratory waste
Hazardous Waste Classification: Handle as cytotoxic or antineoplastic pharmaceutical waste; assign EPA code as appropriate for laboratory hazardous waste manifest
Environmental Considerations: All spills and disposal operations should prevent release to surface water, soil, or groundwater
UN Number: UN2811 (Toxic Solid, Organic, n.o.s.)
Proper Shipping Name: Toxic Solid, Organic, n.o.s. (contains 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine Ditartrate)
Hazard Class: 6.1 (Toxic substance)
Packing Group: II (Medium hazard)
Marine Pollutant: Yes, under IMDG for aquatic toxicity
Special Transportation Notes: Secure containers in secondary containment; notify transport agencies; ensure compliance with national and international cytotoxic material transport rules
OSHA Status: Not listed as a specific OSHA-regulated substance, but recommended controls align with occupational cytotoxic compound standards
TSCA Inventory: Not listed; research compound exempt for laboratory use
SARA Title III: Not present on SARA 302/304/313 lists, but reporting may be triggered by waste volumes
California Prop 65: Not specifically listed, structurally similar compounds have been included for genotoxicity concerns
REACH Registration: Not registered for commercial use in the EU; available for research only
International Inventory Status: Absent from Canadian DSL, Australia AICS, Japan ENCS, and other regulatory lists
Other Regulation: Use and transfer tightly restricted by pharmaceutical precursor guidelines; require specific handling credentials in many regions
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