Material Safety Data Sheet: 3-(N-Piperidyl)-1,1-diphenyl-1-propanol hydrochloride

Identification

Product Name: 3-(N-Piperidyl)-1,1-diphenyl-1-propanol hydrochloride
Chemical Formula: C20H25NO·HCl
Synonyms: Diphenylpropanolpiperidine hydrochloride
Recommended Use: Research, chemical synthesis
Restrictions on Use: Not for human or veterinary medicine
Supplier Details: Commercial chemical supply companies, laboratory distributors
Emergency Contact: Emergency Response Center, 24-hour access number (manufacturer-specific)
CAS Number: 34682-13-8
UN Number: UN1993 (for transport classification)

Hazard Identification

Hazard Classification: Harmful if swallowed, irritating to eyes, respiratory system, and skin
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause respiratory irritation, may cause drowsiness or dizziness, suspected of causing genetic defects with prolonged exposure
Precautionary Statements: Avoid breathing dust, use only outdoors or in a well-ventilated area, wear protective gloves and eye protection, wash skin thoroughly after handling
GHS Pictograms: Exclamation mark, health hazard
Route of Exposure: Inhalation, ingestion, skin and eye contact
Potential Health Effects: Central nervous system depression, respiratory irritation, possible long-term organ effects

Composition / Information on Ingredients

Chemical Name: 3-(N-Piperidyl)-1,1-diphenyl-1-propanol hydrochloride
Concentration: >98% (lab grade)
Impurities: Possible trace residuals from synthesis (organic solvents, reaction byproducts)
Molecular Weight: 327.88 g/mol
Ingredient Category: Substituted diphenylmethanol piperidine compound
Other Additives: None
Stabilizers: None

First Aid Measures

General Information: Remove source of exposure, seek medical advice promptly
If Inhaled: Move person to fresh air, provide artificial respiration if breathing is difficult, consult physician
If In Eyes: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing, seek medical attention
If On Skin: Remove contaminated clothing, wash skin with soap and water, monitor for signs of irritation
If Swallowed: Rinse mouth, do not induce vomiting, seek immediate medical help
Important Symptoms: Drowsiness, dizziness, respiratory discomfort, redness or itching of skin or eyes
Advice for Doctors: Treat symptomatically, consider monitoring kidney and liver function after substantial exposure

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam
Unsuitable Media: Water jets (may spread fire)
Specific Hazards: Toxic fumes of carbon monoxide, nitrogen oxides, hydrogen chloride, and carbon dioxide possible during combustion
Protective Equipment: Self-contained breathing apparatus, full protective firefighting gear
Hazardous Combustion Products: Carbon monoxide, hydrogen chloride gas
Fire-Fighting Instructions: Evacuate area, keep containers cool with water spray from safe distance, avoid inhaling fumes

Accidental Release Measures

Personal Precautions: Provide adequate ventilation, avoid dust generation, wear protective gloves, safety goggles, and P2/P3 particulate respirator
Environmental Precautions: Prevent entry into drains, surface water, or soil
Methods for Containment: Use inert absorbent material (vermiculite, sand)
Clean-Up Procedures: Sweep spills into suitable container, transfer to chemical waste drum, clean surface with water and detergent
Disposal of Contaminated Material: Treat as hazardous waste, contact authorized disposal company
Decontamination: Wash area with soapy water, ventilate before reuse

Handling and Storage

Handling Precautions: Wear protective gloves, avoid direct contact with skin, eyes, or clothing, keep containers closed
Avoid Actions: Eating, drinking, or smoking in work area, unnecessary exposure to dust
Technical Measures: Work in chemical fume hood
Storage Conditions: Store in tightly closed, light-resistant containers at controlled room temperature (15–25°C)
Separation: Keep away from acids, oxidizers, strong bases
Incompatible Materials: Strong oxidizing agents, reducing agents, acids
Storage Area: Clearly labeled, lockable poison cabinet

Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust ventilation, chemical fume hood wherever dust is generated
Exposure Limit Values: No official occupational exposure limits established, follow good laboratory hygiene
Personal Protective Equipment: Chemical safety goggles, lab coat, nitrile or latex gloves, P2/P3 mask
Environmental Exposure Controls: Prevent product from entering drains
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing before leaving lab
Monitoring: Periodic air monitoring recommended for high frequency use

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Faint, characteristic
Odor Threshold: Not established
pH: 4–6 (aqueous solution)
Melting Point: 225–230°C (decomposition)
Boiling Point: Decomposes before boiling
Flash Point: Not determined
Evaporation Rate: Not applicable
Flammability: Not classified as highly flammable
Vapor Pressure: Negligible at room temperature
Solubility: Soluble in water, ethanol, methanol
Partition Coefficient (log Kow): Not determined
Viscosity: Not applicable
Density: 1.1–1.3 g/cm³ (estimated)

Stability and Reactivity

Stability: Chemically stable under recommended handling and storage
Reactivity: Inert under normal laboratory conditions
Possible Hazardous Reactions: Violent reaction with strong oxidizing agents, acids
Conditions to Avoid: Moist air, high temperatures, open flame
Incompatible Materials: Strong oxidizing materials, mineral acids, strong bases
Hazardous Decomposition Products: Hydrochloric acid, carbon monoxide, nitrogen oxides under fire conditions

Toxicological Information

Acute Toxicity: Data not fully established, based on similar compounds moderate oral toxicity in rodents
Skin Corrosion/Irritation: Possible mild to moderate irritation
Eye Damage/Irritation: Causes irritation, risk of corneal injury
Respiratory Sensitization: May cause sneezing, coughing, breathing difficulty
Skin Sensitization: Prolonged or repeated exposure may lead to dermatitis
Chronic Toxicity: Prolonged exposure: risk of adverse effects on central nervous system, kidneys, and liver
Mutagenicity: Not fully evaluated, exercise caution
Carcinogenicity: No data available, not listed by IARC, NTP, or OSHA
Reproductive Toxicity: Potential risk cannot be excluded
Symptoms of Exposure: Drowsiness, headache, nausea, eye and skin redness, dizziness

Ecological Information

Aquatic Toxicity: No data available; similar amines may be moderately toxic to fish and invertebrates
Persistence and Degradability: Not readily biodegradable, will likely persist in the environment
Bioaccumulation Potential: Expected to have low potential for bioaccumulation based on structure
Soil Mobility: Likely to bind to sediments and organic matter
Other Environmental Hazards: Effect on microbial activity possible, prevent large releases
Product Behavior: No known significant environmental hazards with proper handling and disposal

Disposal Considerations

Waste Disposal Methods: Handle as chemical hazardous waste, incinerate according to local, regional, and national requirements
Container Disposal: Triple-rinse lab containers, ensure residues are removed before recycling or disposal
Precautions for Disposal: Do not allow material to enter watercourses or soil; always use licensed chemical disposal facilities
Additional Considerations: Consult relevant EPA, local environmental and waste management authorities before disposing

Transport Information

UN Number: UN1993 (if classified as flammable liquid)
Proper Shipping Name: Laboratory chemical, organic solid or solution
Transport Hazard Class: Not classified as dangerous for most transport under standard conditions
Packing Group: III
Special Precautions: Keep away from moisture, ensure container integrity
Environmental Hazards: Not a marine pollutant
Transport in Bulk: Avoid exposure to sunlight, keep cool in transit

Regulatory Information

TSCA Inventory (USA): May not be listed for commercial use
REACH Status (EU): Not registered for commercial distribution
Hazard Communication Standard: Meets requirement for laboratory chemical labeling
WHMIS (Canada): Controlled product, use lab restrictions
SARA 313: Not subject to reporting
California Proposition 65: Not listed as carcinogen or reproductive toxin
Other Restrictions: For research only, not for diagnostic or therapeutic use, sales restricted to qualified professionals