Product Name: 3-Mercapto-1,2-propanediol
Synonyms: 2,3-Dihydroxypropanethiol, Thioglycerol
Chemical Formula: C3H8O2S
CAS Number: 96-27-5
Recommended Use: Common in chemical and biochemical research, acts as a reducing agent and stabilizer.
Supplier Information: Chemical distributors and laboratory suppliers.
Emergency Contact: Use local poison center, chemical spill hotline, or fire department.
GHS Classification: Acute toxicity, skin and eye irritation, specific target organ toxicity after single exposure.
Label Elements: GHS05 (Corrosive), GHS07 (Harmful), exclamation mark symbol.
Hazard Statements: Causes skin and eye irritation, harmful if swallowed or inhaled, may cause respiratory tract irritation.
Precautionary Statements: Avoid contact with skin and eyes, avoid breathing vapors, wash thoroughly after handling.
Routes of Entry: Inhalation, skin and eye contact, ingestion.
Other Hazards: Strong, unpleasant odor, potential for allergic skin reactions in certain individuals.
Chemical Name: 3-Mercapto-1,2-propanediol
Concentration: 97-100%
Impurities: Minimal amounts of related thiol or polyol compounds possible depending on the supplier.
CAS Number: 96-27-5
EC Number: 202-495-0
Inhalation: Take person into fresh air, keep them at rest, seek medical attention for breathing difficulties.
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water and soap, seek medical advice if irritation develops.
Eye Contact: Rinse eyes slowly and gently with lots of water for at least 15 minutes, remove contact lenses, seek immediate medical attention.
Ingestion: Rinse mouth, do not induce vomiting, give plenty of water if conscious, seek medical attention immediately.
Most Important Symptoms/Effects: Irritation, redness, swelling, headache, nausea, dizziness, respiratory distress can develop if exposed to high concentrations.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, carbon dioxide, dry chemical.
Specific Hazards: Vapors may be irritating, can emit toxic fumes under fire conditions including sulfur oxides, carbon monoxide, carbon dioxide.
Protective Equipment: Firefighters need self-contained breathing apparatus and protective clothing.
Special Procedures: Use water spray to cool containers, stay upwind, prevent runoff from extinguishing media entering drains.
Combustion Products: Sulfur oxides, carbon oxides.
Personal Precautions: Ventilate area, use appropriate personal protective equipment such as gloves, goggles, lab coat or overalls, avoid breathing vapors.
Environmental Precautions: Contain spill, prevent entry into drains, sewers, or natural watercourses.
Cleanup Methods: Absorb with inert material like sand, transfer to waste container, use non-sparking tools, clean spill area thoroughly with soap and water.
Notification: Inform environmental authorities if significant quantities enter water or soil.
Handling: Use in well-ventilated areas, avoid direct contact, wash hands after handling, keep containers tightly closed, avoid sources of ignition.
Storage: Store away from incompatible substances like oxidizers and acids, keep at room temperature in a cool, dry, well-ventilated place, avoid sunlight, clearly label storage containers, ensure secondary containment for larger volumes.
Exposure Limits: No specific occupational exposure limits published, handle as potentially hazardous.
Engineering Controls: Use chemical fume hood or local exhaust ventilation.
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), safety goggles, face shield in case of splashing, lab coat or full protective suit.
Hygiene Measures: Do not eat, drink, or smoke when handling, maintain good industrial hygiene and safety practices, immediately remove contaminated clothing and wash it before reuse.
Respiratory Protection: Use approved respirator for exposure above recommended levels, particularly for inadequate ventilation conditions.
Appearance: Colorless to pale yellow, viscous liquid.
Odor: Strong, characteristic sulfur-like, unpleasant odor.
Odor Threshold: Detectable at very low concentrations.
pH: Neutral to slightly acidic in solution.
Melting Point: 45-50 °C
Boiling Point: Approximately 220-230 °C
Flash Point: Around 120 °C (closed cup)
Evaporation Rate: Low at room temperature.
Flammability: Not highly flammable but can burn.
Vapor Pressure: Very low at room temperature.
Vapor Density: Heavier than air.
Specific Gravity: 1.290-1.320
Solubility: Completely soluble in water, ethanol, and most polar solvents.
Partition Coefficient (Log Kow): Low, high water solubility.
Auto-ignition Temperature: Not established.
Decomposition Temperature: Above 230 °C.
Viscosity: High compared to water.
Molecular Weight: 108.16 g/mol
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Reacts with strong oxidizers, acids, and alkalis.
Hazardous Reactions: Exposure to high temperatures or mixing with strong oxidizers produces heat, toxic gases.
Conditions to Avoid: Heat, flames, incompatible materials like oxidizing agents.
Incompatible Materials: Strong acids, oxidizing agents, bases.
Hazardous Decomposition Products: Carbon oxides, sulfur oxides, hydrogen sulfide.
Acute Toxicity: Oral LD50 (rat): approx. 260 mg/kg, inhalation and dermal toxicity data limited, classified as harmful by ingestion and skin exposure.
Irritation: Causes skin and eye irritation, repeated exposure increases risk.
Sensitization: Can cause allergic skin reactions in susceptible persons.
Inhalation: Vapors may be irritating to respiratory tract, symptoms of exposure: cough, headache, dizziness.
Ingestion: Harmful if swallowed, may cause nausea, vomiting, abdominal pain.
Chronic Effects: Long-term data limited, may cause dermatitis or sensitization with repeated contact.
Mutagenicity/Carcinogenicity: No evidence found in limited animal studies, not classified as a carcinogen by regulatory authorities.
Reproductive Toxicity: No data available, recommended to avoid exposure during pregnancy out of caution.
Symptoms of Exposure: Irritation, itching, redness, respiratory symptoms.
Aquatic Toxicity: Moderate toxicity to aquatic organisms based on predicted data, not persistent, biodegradability increases with exposure to sunlight and microbial action.
Bioaccumulation: Low potential, rapid breakdown expected in water.
Mobility in Soil: High solubility in water promotes migration in soil, unlikely to adsorb strongly.
PBT/vPvB Assessment: Not identified as persistent, bioaccumulative or toxic.
Other Adverse Effects: Odorous thiol compounds can have negative impacts on wastewater treatment and sensitive environments, release into environment should be minimized.
General Disposal: Dispose of as hazardous chemical waste as per local, state, or national regulations, not suitable for household or municipal waste streams.
Contaminated Packaging: Wash with plenty of water, dispose in approved facility.
Disposal Methods: Incinerate in approved facility, avoid landfill disposal, do not pour into drains or surface water.
Additional Precautions: Contact licensed waste disposal company, document disposal procedures for regulatory compliance, retain disposal records.
UN Number: Not officially listed, but handle as hazardous for transport.
UN Proper Shipping Name: 3-Mercapto-1,2-propanediol or Organic Liquid, n.o.s. (not otherwise specified).
Transport Hazard Class: Class 6.1 (toxic substances), not regulated for domestic ground transport in small quantities.
Packing Group: III (minor hazard)
Marine Pollutant: No.
Special Precautions: Ensure packaging prevents leaks and odor, avoid transport with foodstuffs or feed, follow carrier and international guidelines for chemical shipments.
ICAO/IATA-DGR, IMDG, ADR/RID: Typically not specifically regulated but should be packed to minimize risk of exposure and accidental release during transit.
US TSCA: Listed.
DSL/NDSL (Canada): Listed.
REACH (EU): Registration not currently required in small volumes for lab use, check for updates.
OSHA Hazard Communication: Classified hazardous.
SARA Title III, Sections 302/304/311/312/313: Not listed as extremely hazardous, may trigger reporting requirements above certain volumes.
California Proposition 65: Not listed.
Right-to-Know Lists (NJ, PA, MA): Included.
Workplace Labels: Must include chemical name, hazard statements, and pictograms.
Other Requirements: Maintain detailed records of acquisition, handling, and disposal for regulatory authorities, update risk assessments annually.
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