Product Name: 3-Chloropropylene glycol
Synonyms: 3-Chloro-1,2-propanediol, α-chlorohydrin
CAS Number: 96-24-2
Recommended Use: Industrial chemical, intermediate in organic synthesis
Manufacturer/Supplier: Refer to supplier documentation for current contact details, including telephone for emergencies
Emergency Contact: Use global emergency services, such as CHEMTREC, for release or exposure situations
Address: Detailed company and site address should be included on packaging and delivery notes
Classification: Acute Toxicity (Oral, Dermal, Inhalation), Skin Irritation, Eye Irritation, Mutagenicity, Carcinogenicity
GHS Label Elements: Signal word: Danger
Hazard Statements: Harmful if swallowed; toxic in contact with skin or if inhaled; causes skin and eye irritation; suspected of causing genetic defects; may cause cancer
Precautionary Statements: Avoid all routes of exposure, wear protective equipment, follow safe handling procedures, use only outdoors or in well-ventilated area, keep container closed
Physical Hazards: None expected under standard conditions, flammable at elevated temperatures
Environmental Hazards: Harmful to aquatic life with long-lasting effects
Chemical Name: 3-Chloropropylene glycol
Synonyms: 3-Chloro-1,2-propanediol
Chemical Formula: C3H7ClO2
CAS Number: 96-24-2
Purity: ≥ 97%
Impurities: Traces of water, diol isomers, other chlorinated compounds below threshold for reporting
Specific Concentration Limits: Pure substance; not a mixture
Inhalation: Move affected person to fresh air, keep warm and at rest, seek immediate medical attention for cough, shortness of breath, or persistent symptoms
Skin Contact: Remove contaminated clothing, rinse affected skin with plenty of water for at least 15 minutes, seek medical attention for persistent irritation
Eye Contact: Immediately rinse with plenty of water for several minutes, remove contact lenses if easy to do, continue rinsing, obtain medical attention
Ingestion: Do not induce vomiting, rinse mouth with water, immediately seek medical advice, provide information about product
Symptoms: Irritation, burns, dizziness, coughing, headache, gastrointestinal distress, decreased coordination, possible delayed effects
Medical Attention: Urgent for significant exposure, carry safety data sheet for prognosis and treatment guidance
Extinguishing Media: Use foam, dry chemical, carbon dioxide (CO2), or water spray for larger fires
Hazards from Combustion: Generates toxic gases including hydrogen chloride, carbon monoxide, carbon dioxide, possible corrosive mists
Special Protective Equipment: Firefighters should use self-contained breathing apparatus with full face shield, chemical-resistant suit recommended
Procedures: Remove containers from fire area if safe, cool containers with water spray, avoid water stream directed on material itself
Hazardous Decomposition: Hydrogen chloride, phosgene, carbon oxides
Personal Precautions: Restrict access, ventilate area, avoid inhalation or skin contact, use personal protective equipment suitable for chemical spills
Environmental Precautions: Prevent from entering drains, surface water, ground water, soil
Containment: Stop leak if safe, dike spill with sand or earth
Cleaning Methods: Absorb with inert material (sand, vermiculite), collect into chemical waste containers, rinse spill area after removal with water, avoid further contamination
Disposal: Follow local, regional, national guidelines for hazardous waste disposal, do not flush to sewage
Handling: Use closed systems or proper ventilation, avoid breathing vapors or contact with liquids, keep away from food and beverages, follow protocols to prevent static discharge
Hygiene: Wash hands thoroughly after handling, remove contaminated clothing and wash before reuse
Storage Conditions: Store in cool, dry, well-ventilated, locked area, segregate from incompatible substances (acids, oxidizers, alkalis), keep container tightly closed
Packaging Materials: Use only containers resistant to chlorinated solvents, labeled for hazardous content
Incompatibilities: Strong acids, alkalis, oxidizers, reactive metals
Permissible Exposure Limits: Consult national OELs; ACGIH TLV for similar compounds is often used as guideline (not formally established for all countries)
Engineering Controls: Provide exhaust ventilation, process enclosures, local extraction
Respiratory Protection: Use NIOSH-approved respirator with organic vapor/acid gas cartridge under insufficient ventilation
Skin Protection: Wear chemical-resistant gloves (nitrile, neoprene), full-body suit
Eye Protection: Splash-proof goggles, face shield for overhead or high-volume activities
Other Protection: Eyewash station, safety shower nearby, no contact lenses in lab, use protective footwear
Appearance: Colorless to pale yellow viscous liquid
Odor: Slight, sweet-chlorinated odor
Molecular Weight: 110.54 g/mol
pH: Slightly acidic
Melting Point: -18°C
Boiling Point: 213°C
Flash Point: 113°C (closed cup)
Evaporation Rate: Not rapid
Flammability: Not highly flammable, combustible at elevated temperatures
Vapor Pressure: 0.17 mmHg at 25°C
Solubility: Fully miscible in water
Density: 1.32 g/cm³ at 20°C
Viscosity: 40-60 mPa•s at 20°C
Partition Coefficient (log Kow): -0.36
Decomposition Temperature: No information provided by suppliers, typically above 180°C
Chemical Stability: Stable in storage under recommended conditions
Reactivity: May react with strong oxidants, strong acids, alkalis, reactive metals forming hazardous products
Hazardous Reactions: Decomposition at high temperature produces toxic gases
Polymerization: No hazardous polymerization under normal handling
Conditions to Avoid: High temperatures, open flames, incompatible chemicals
Hazardous Decomposition Products: Hydrogen chloride, phosgene, carbon monoxide, carbon dioxide
Acute Toxicity: LD50 (oral, rat): 55-100 mg/kg; LD50 (dermal, rabbit): ~250 mg/kg; can be lethal in high doses
Skin Irritation: Causes irritation, redness, possible burns on prolonged exposure
Eye Irritation: Severe irritation, possible corneal injury
Inhalation Effects: Respiratory irritation, dizziness, central nervous system depression
Mutagenicity: Evidence of genetic mutations in laboratory studies
Carcinogenicity: Classified as possibly carcinogenic to humans (IARC Group 2B)
Other Effects: May cause drowsiness, vomiting, ataxia, liver and kidney damage after repeated exposure
Chronic Effects: Possible reproductive and developmental toxicity in long-term animal testing
Routes of Exposure: Inhalation, ingestion, skin and eye contact pose health risks
Ecotoxicity: Moderately toxic to aquatic organisms, EC50 (daphnia): 34 mg/L (48h), LC50 (fish): 18–85 mg/L (96h)
Persistence and Degradability: Slow biodegradation, risk of accumulating in water bodies
Bioaccumulative Potential: Low (log Kow <0)
Mobility in Soil: High mobility due to water solubility, may contaminate groundwater if not contained
Other Adverse Effects: Possible endocrine disruption in aquatic life, evidence of chronic toxicity at low concentrations
Precautions: Prevent release into environment, treat effluent before discharge
Waste Treatment Methods: Dispose as hazardous chemical waste per local and national guidelines
Product Disposal: Incinerate in authorized waste facility, avoid unauthorized landfilling or dilution
Container Disposal: Triple rinse containers and puncture before disposal, label as hazardous
Precautions: Never dispose of through sinks or drains, handle residues as for neat material
UN Number: UN 2810
Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 3-Chloro-1,2-propanediol)
Transport Hazard Class: 6.1 (Toxic Substance)
Packing Group: II
Labels Required: Toxic
Transport by Land (ADR/RID): Classified as hazardous, ensure packaging and documentation are compliant
Transport by Sea (IMDG): Classified as marine pollutant
Transport by Air (IATA): Transport only as compliant with IATA Dangerous Goods Regulations, use appropriate packaging
Special Precautions: Secure containers, segregation from foodstuffs, keep away from heat during transit
Safety, Health, Environmental Regulations: Listed as hazardous substance under major chemical safety frameworks (OSHA, REACH, GHS)
U.S. TSCA: Listed
EU REACH: Registration required, subject to restrictions
Classification according to EC Directives: Harmful (Xn), Irritant (Xi), Toxic (T), Environmental Hazard (N) labels may apply
Workplace Regulations: Employers required to provide worker training, emergency planning, spill response protocols, and regular health monitoring
Other Regulations: Included in inventories such as AICS (Australia), DSL (Canada), ENCS (Japan), KECL (South Korea), PICCS (Philippines)
Labelling: All containers must be clearly labeled, hazard pictograms, safety phrases, and risk statements provided in language of receiving country
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