Product Name: 3-Chloro-1-propanol
Chemical Formula: C3H7ClO
Synonyms: 1-Propanol, 3-chloro-
CAS Number: 627-30-5
Manufacturer/Supplier: Refer to current supplier contact details
Recommended Use: Intermediate for chemical synthesis, solvent use in research laboratories, component in organic synthesis
Emergency Number: Contact local emergency services or company-specific emergency contacts for immediate response
Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritant, aquatic toxicity
GHS Label Elements: Danger signal word, skull and crossbones pictogram, exclamation mark pictogram
Hazard Statements: Harmful if swallowed, in contact with skin or if inhaled; causes skin and eye irritation; toxic to aquatic life with long lasting effects
Precautionary Statements: Avoid breathing vapors, use only outdoors or in well-ventilated area, wash thoroughly after handling, avoid release to environment, wear protective gloves, eye and face protection, contaminated work clothing should not be allowed out of the workplace
Description of Hazards: Exposure can irritate eyes, skin, and airways, can lead to headaches, dizziness, and at high doses, poisoning; long-term environmental damage possible if released in significant amounts
Chemical Name: 3-Chloro-1-propanol
Concentration: 98% or higher when used in pure form; may appear in mixtures at reduced concentrations where marked
Impurities: Typical impurities can include water, propylene oxide, glycols in trace quantities; check latest batch certificate for specifics
Ingredient Contribution to Hazard: Main risk arises from chloro and alcohol functional groups, which can affect both human health and environment through different exposure pathways
Eye Contact: Immediately flush with plenty of water for at least 15 minutes, remove contact lenses if present and not stuck, continue rinsing; seek medical attention even if symptoms appear minor
Skin Contact: Remove contaminated clothing, rapidly wash skin with soap and water, do not reuse clothing until thoroughly cleaned, medical consultation advised for persistent irritation
Inhalation: Move person into fresh air, keep warm and at rest, if breathing is difficult provide oxygen, if not breathing give artificial respiration; contact poison control right away
Ingestion: Rinse mouth with water, do not induce vomiting unless guided by medical personnel, provide water to dilute if person is fully conscious, seek immediate medical help
Symptoms to Watch: Signs include coughing, sore throat, headache, nausea, redness of skin or eyes, possible burning sensation, confusion may occur in severe cases
Advice for Rescuers: Ensure your own safety by wearing gloves and respiratory protection, avoid mouth-to-mouth resuscitation unless barrier devices are available
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray/fog (not straight stream)
Unsuitable Media: Straight water jets can spread the chemical or fire
Hazardous Combustion Products: Hydrogen chloride, carbon monoxide, phosgene, chlorine gases possible during combustion
Protective Equipment: Firefighters require full protective gear, including self-contained breathing apparatus
Special Procedures: Cool exposed containers with water spray, approach from upwind, prevent contaminated water runoff from entering drains or watercourses; evacuate area if large spill or significant fire occurs
Emergency Procedures: Evacuate unnecessary personnel, ventilate area, isolate spill site
Personal Precautions: Wear respirator, chemical-resistant gloves, goggles, protective clothing
Environmental Precautions: Prevent entry into sewers, soil, waterways; try to contain runoff with bunds or absorbents
Spill Cleanup: Absorb with inert material (sand, vermiculite), scoop up and place in labeled chemical waste container, clean area with large quantities of water, ventilate well afterwards
Disposal for Contaminated Material: Dispose of clean-up residues as hazardous waste according to local and national regulations
Precautions for Safe Handling: Use only in fume hood or well-ventilated lab, avoid contact with eyes, skin, clothing, never ingest or inhale vapors; keep away from sources of ignition, heat, and incompatible substances
Hygiene Measures: Wash hands before breaks, after handling, and before eating or drinking; remove contaminated clothing immediately
Safe Storage Conditions: Store in tightly closed containers in a cool, dry, well-ventilated space, away from direct sunlight, moisture, and incompatible material like oxidizers or strong bases; containers should be properly labeled and locked away from unauthorized personnel
Occupational Exposure Limits: No established OSHA or ACGIH limits; minimize exposure as much as possible through engineering controls
Engineering Controls: Local exhaust ventilation, chemical fume hoods preferred for laboratory procedures
Personal Protective Equipment: Chemical splash goggles, face shields, impervious gloves (nitrile, butyl rubber preferred), lab coat or full-body suit, respiratory protection in poorly ventilated environments or if airborne levels exceed safe limits
Environmental Controls: Regular monitoring of air and wastewater for contamination; spill kits and eye-wash stations in areas where product is used
Appearance: Clear, colorless to pale yellow liquid
Odor: Slight alcohol-like, pungent
Boiling Point: 156°C (312.8°F)
Melting Point: -48°C (-54.4°F)
Flash Point: 67°C (153°F, closed cup)
Solubility: Miscible in water, soluble in ketones and alcohols
Vapor Pressure: 0.4 hPa at 20°C (68°F)
Density: 1.143 g/cm³ at 20°C
pH: Not applicable (neutral in solution)
Partition Coefficient (log Kow): Estimated -0.50
Decomposition Temperature: Decomposes above 200°C, releasing hydrochloric acid and toxic vapors
Chemical Stability: Stable under normal conditions; prolonged exposure to heat or sunlight can cause decomposition
Conditions to Avoid: Open flames, sparks, static discharge, high temperatures, strong UV radiation
Incompatible Materials: Strong oxidizing agents, strong alkalis, strong acids, reactive metals
Hazardous Decomposition Products: Chlorinated compounds, carbon monoxide, carbon dioxide, hydrogen chloride
Polymerization: No hazardous polymerization under recommended storage and handling conditions
Routes of Exposure: Skin contact, eye contact, inhalation, ingestion
Acute Toxicity: LD50 (oral, rat): 308 mg/kg; LD50 (dermal, rabbit): 2960 mg/kg
Skin/Eye Irritation: Causes moderate to severe irritation, possible burns on prolonged contact
Chronic Effects: Prolonged or repeated exposure may affect central nervous system and liver; no definitive evidence of carcinogenicity according to available public data
Sensitization: No known sensitization, but data limited
Symptoms: Burning sensation, redness, pain, coughing, dizziness, headache, nausea, respiratory discomfort
Medical Conditions Aggravated: Pre-existing skin conditions, asthma, allergies, liver and kidney disorders
Ecotoxicity: Highly toxic to aquatic life, fish LC50 (96h): estimated 22 mg/L, caution near waterways
Persistence and Degradability: Readily biodegradable in aqueous environment through microbial action, but persistence possible in soil with slow leaching
Bioaccumulation: Low bioconcentration expected (log Kow negative), minimal risk of food chain accumulation
Mobility in Soil: Moderately mobile, potential for groundwater contamination in large spills
Additional Information: Prevent large-scale or repeated releases; harmful long-term impact if soil or sediment becomes contaminated
Product Disposal: Treat as hazardous waste in accordance with local, state, and national regulations; incineration in chemical incinerator equipped with afterburner recommended for liquid waste
Container Disposal: Triple rinse with compatible solvent before disposal, puncture and render containers unusable, send to appropriate hazardous waste facility
Avoided Methods: Do not discharge to sewer, water bodies, or open environment
Waste Codes: Consult with local regulatory authority to determine appropriate waste code based on local legislation
UN Number: 1993
Shipping Name: Flammable Liquid, n.o.s. (3-Chloro-1-propanol)
Hazard Class: 3 (Flammable Liquid)
Packing Group: III
Label: Flammable liquid, environmental hazard
Special Precautions: Keep away from foodstuffs, strong oxidizers, incompatible materials during transport; drivers should carry chemical emergency cards and be trained in spill response
Marine Pollutant: Yes—classified as hazardous to aquatic environment
Other Information: Check national or regional transport regulations, variations can occur between countries
EU Regulations: Subject to REACH provisions, hazardous chemical classification and labeling per CLP regulation; safety phrases and hazard codes enforced under EU law
US Regulations: TSCA inventory listing, not subject to SARA Title III Section 313 or CERCLA reporting; state regulations may mandate additional handling and disclosure
Canadian Regulations: Listed on DSL, subject to Workplace Hazardous Materials Information System (WHMIS) as Class D2B, skin/eye irritant
International Regulations: Local authorities should be consulted for import, use, and disposal licenses and other requirements; ensure up-to-date recordkeeping and hazard communication in all jurisdictions
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