Substance Name: 3-Chloro-1-phenylpropanol
Synonyms: 3-Chloro-1-phenyl-1-propanol; β-Chlorohydrocinnamyl alcohol
Recommended Use: Laboratory chemical, research and development
Manufacturer: Specialty chemical supplier
Emergency Phone: Refer to local resource
Product Code: Provided by distributor
Chemical Formula: C9H11ClO
CAS Number: 22136-31-2
Classification: Skin irritation, category 2; Eye irritation, category 2A; Acute toxicity (oral), category 4
Label Elements: Pictogram: Exclamation mark
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, harmful if swallowed, may cause respiratory irritation
Precautionary Statements: Avoid breathing dust or vapors, wash hands after handling, use only outdoors or in a well-ventilated area, wear protective gloves and eye protection
Target Organs: Skin, eyes, respiratory system
Potential Health Effects: Inhalation can cause coughing, shortness of breath, sore throat. Skin contact may lead to redness, irritation, and possible allergic reaction. Eye splashes can trigger redness and watering. Swallowing poses risk of abdominal cramps, nausea, and vomiting.
Chemical Name: 3-Chloro-1-phenylpropanol
Concentration: ≥98%
Impurities: Trace amounts of starting materials and byproducts, typically below 2%
Molecular Weight: 170.64 g/mol
Relevant Impurities: Unreacted benzyl chloride or phenylpropanol derivatives may appear in batches
General Advice: Seek medical assessment after significant exposure
Inhalation: Move to fresh air, keep affected person warm and at rest, seek medical advice
Skin Contact: Remove contaminated clothing, wash affected skin with plenty of soap and water, avoid abrading the skin, seek attention if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, seek prompt eye care for ongoing symptoms
Ingestion: Rinse mouth, do not induce vomiting, drink water if conscious, get medical help
Most Important Symptoms: Redness, pain, possible delayed skin reaction
Notes for Physicians: Treat symptomatically, monitor respiratory and cardiovascular function
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water fog
Unsuitable Extinguishing Media: Direct water streams may spread chemical
Special Hazards: Releases toxic fumes of hydrochloric acid and carbon oxides under fire
Protective Equipment: Self-contained breathing apparatus, full protective suit
Specific Methods: Isolate hazard area, remove nearby chemicals, cool surroundings with water spray, avoid water runoff into sewers
Combustion Products: Hydrogen chloride gas, carbon monoxide, carbon dioxide, unknown organics
Personal Precautions: Evacuate unnecessary staff, ventilate the area, avoid breathing vapors, use appropriate personal protective equipment (PPE)
Environmental Precautions: Prevent entering drains, soil, or watercourses, inform authorities if major spillage
Methods for Clean-Up: Absorb with inert material (sand, vermiculite), collect in suitable containers, wash spill area with detergent and water, dispose of in accordance with regulations
Secondary Prevention: Avoid generating dusty conditions; contain spillage
Handling: Work with gloves, chemical goggles, and body protection; make sure to use efficient local exhaust or general ventilation to minimize exposure
Advice on Safe Handling: Wash thoroughly before eating, drinking, or using restroom; avoid contact with skin and eyes; do not inhale mist or vapor; use only in a chemical fume hood
Storage: Store in tightly sealed container in cool, dry, well-ventilated space, away from incompatible substances such as oxidizing agents; keep segregated from food, crushing impact, or heat sources; keep container labeled
Incompatible Products: Strong acids, strong bases, strong oxidizers
Occupational Exposure Limits: No specific limits assigned, yet minimize exposure using best-practice engineering controls
Engineering Controls: Local exhaust ventilation, eyewash stations, emergency showers
Personal Protection:
- Respiratory: Wear NIOSH-approved respirator if risk of inhalation
- Eyes: Chemical splash goggles, face shield if splashing possible
- Skin: Chemical-resistant gloves (nitrile or better), lab coat or apron, remove contaminated clothing promptly
Environmental Exposure Controls: Avoid discharge to environment, use containment features or spill trays
Appearance: Colorless to pale yellow liquid or crystalline solid, slight aromatic odor
Melting Point: 31-34 °C
Boiling Point: 133-135 °C at 11 mmHg
Solubility: Slightly soluble in water, soluble in ethanol, chloroform, and most organic solvents
Density: 1.15-1.17 g/cm³
Vapor Pressure: Low at ambient temperature
pH: Not applicable
Flash Point: >100 °C (closed cup)
Partition Coefficient (log Pow): Estimated 1.7 - 2.2
Viscosity: Not established
Stability: Stable under recommended handling and storage conditions
Thermal Decomposition: May form hazardous gases above 180 °C
Reactive With: Strong acids, strong oxidizers, alkali metals
Hazardous Polymerization: Not anticipated under normal processing
Dangerous Products of Decomposition: Hydrogen chloride, carbon monoxide, carbon dioxide, phenyl halide fragments
Other Reactivity Notes: Moisture can destabilize; avoid storing with incompatible reactive chemicals
Acute Toxicity: Oral LD50 (rat) estimated between 300-2000 mg/kg
Skin Irritation: Causes moderate irritation on direct contact
Eye Irritation: Results in pain, redness, possible corneal injury if not flushed quickly
Carcinogenicity: No studies indicating carcinogenic risk known, yet not thoroughly studied
Mutagenicity: Not classified, but analogs raise concern for genetic toxicity
Sensitization: Prolonged or repeated skin contact could lead to allergy
Chronic Effects: Repeat exposure may aggravate dermatitis, pre-existing respiratory conditions
Further Health Hazards: Vapors may depress central nervous system or irritate mucous membranes
Ecotoxicity: Expected to be harmful to aquatic invertebrates at moderate concentrations
Persistence and Degradability: Moderately persistent, slow natural breakdown in soil or water
Bioaccumulative Potential: Potential to accumulate in aquatic organisms
Mobility in Soil: May travel through soil due to moderate solubility
Other Adverse Effects: Toxic for algae, low rates of biodegradation may increase persistence in environment
Disposal Methods: Handle as hazardous waste, use a licensed hazardous waste disposal contractor
Waste Code: Assign based on local regulations for chlorinated organic waste
Contaminated Packaging: Dispose of containers as hazardous chemical waste, do not reuse packaging
Disposal Precautions: Clear labeling during transportation to waste site, prevent leaks or spills during storage prior to disposal
UN Number: Not assigned specifically, treat as dangerous goods based on toxicity and reactivity
Proper Shipping Name: Organic liquid, n.o.s. (contains chlorinated aromatic alcohol)
Transportation Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Marine pollutant potential, restrict ocean transport unless in sealed packaging
Special Transport Precautions: Use certified containers, proper physical separation from foodstuffs
Transport Labels: Toxic substances, environmentally hazardous
Occupational Safety and Health: Subject to workplace chemical safety and hazard communication standards in most jurisdictions
Inventory Status: Listed or pre-registered in REACH, TSCA, DSL, and other international regulatory databases
SARA Title III: Not listed as extremely hazardous, yet inclusion under general hazardous substances category possible
Label Requirements: Must display hazard pictograms, signal word, hazard statements as per GHS
Restrictions on Use: For industrial or laboratory use only, not approved for pharmaceuticals or food-grade applications
Other Regulatory Notes: Employer training and risk management programs improve worker safety; regular review of local updates recommended
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