Product Name: 3-Chloro-1,2-Propanediol
Chemical Formula: C3H7ClO2
Synonyms: α-Monochlorohydrin, Glycerol α-monochlorohydrin, Monochlorohydrin
CAS Number: 96-24-2
Recommended Use: Chemical intermediate, laboratory reagent, research and industrial processes
Manufacturer: Company details and contact information must be available on the container label and product documentation
Emergency Phone: Refer to supplier emergency line or local poison control center
Classification: Acute toxicity (oral, dermal, inhalation), skin and eye irritation, carcinogenicity, mutagenicity
Signal Word: Danger
Hazard Statements: Toxic if swallowed, in contact with skin, or if inhaled. Causes serious eye and skin irritation. Suspected of causing cancer and genetic defects. Harmful to aquatic life with long lasting effects.
Pictograms: Skull and crossbones, exclamation mark, health hazard, environment
Precautionary Statements: Avoid contact with skin, eyes, and clothing. Do not eat, drink, or smoke while handling. Wear suitable protective clothing. Use only with adequate ventilation. Wash thoroughly after handling.
Chemical Name: 3-Chloro-1,2-Propanediol
Concentration: >98% by weight
Impurities or Stabilizing Additives: Small amounts of water and process residues possible; no significant stabilizers generally present in high-purity samples
CAS Number: 96-24-2
Other Identifiers: Not typically mixed with other chemical substances for industrial or lab use
Inhalation: Move individual to fresh air, keep at rest. Seek medical attention for any respiratory symptoms or difficulty breathing. Supply oxygen if breathing is difficult.
Skin Contact: Remove contaminated clothing, wash skin thoroughly with water and soap, seek medical attention for persistent irritation or burns.
Eye Contact: Immediately rinse eyes with plenty of water for at least 15 minutes. Hold eyelids apart. Remove contact lenses if present and easy to do. Get medical assistance promptly.
Ingestion: Rinse mouth with water. Do not induce vomiting. Get immediate medical advice.
Notes to Physician: Treat symptoms. Show chemical label or MSDS if possible.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Specific Fire Hazards: May produce toxic and irritating fumes, including hydrogen chloride, carbon oxides during combustion
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Special Precautions: Approach from upwind; contain runoff to prevent environmental contamination
Explosion Hazards: Not classified as an explosive, but vapor mixed with air could form potentially explosive mixtures in confined spaces
Firefighting Procedures: Cool exposed containers with water spray, avoid breathing fumes, contain and collect extinguishing water for disposal
Personal Precautions: Evacuate area, restrict access to authorized personnel wearing protective gear
Environmental Precautions: Prevent spillage from entering drains, surface water, or soil. Report to authorities if contaminating waterways.
Cleanup Methods: Absorb spills with inert material such as sand or vermiculite. Collect and place in appropriate closed containers for disposal. Clean area thoroughly. Ventilate area well.
Disposal: Follow local environmental and safety regulations for disposal. Decontaminate tools and equipment.
Emergency Procedures: Set up emergency barriers. Provide appropriate safety signage.
Precautionary Handling: Use in well-ventilated areas. Avoid inhalation of vapors or contact with skin and eyes. Do not eat, drink, or smoke in work area. Remove contaminated clothing.
Storage Conditions: Store in tightly closed, labeled containers in cool, dry, well-ventilated area away from incompatible substances such as strong oxidizers and acids. Protect from light and moisture.
Container Materials: Use corrosion-resistant containers specifically designed for chemical storage.
Other Precautions: Limit quantity stored. Monitor for leaks or spills. Keep away from heat, sparks, or open flames.
Exposure Limits: No established OSHA/ACGIH limits for 3-Chloro-1,2-Propanediol, but recommended exposure should be as low as reasonably achievable.
Engineering Controls: Local exhaust ventilation, safety shower, eye wash station in working area
Personal Protective Equipment: Chemical-resistant gloves, safety goggles or face shield, protective clothing (lab coat, apron), chemical respirator if airborne concentrations may occur
Hygiene Measures: Wash hands and face after handling. Remove contaminated clothing and clean before reuse. Use personal protective equipment consistently.
Appearance: Colorless to pale yellow liquid
Odor: Faint, sweetish odor
Melting Point: -42 °C
Boiling Point: 213 °C
Density: 1.32 g/cm3
Solubility: Soluble in water, alcohol, ether
pH: Not available in pure form
Vapor Pressure: 0.033 hPa at 20 °C
Flash Point: 108 °C (closed cup)
Partition Coefficient (log Kow): -0.4
Autoignition Temperature: Data not readily available
Viscosity: Not measured, but indicated to be higher than water
Other Properties: Hygroscopic, stable under typical storage conditions, forms flammable vapors at high temperatures
Chemical Stability: Stable at ambient temperature and pressure under recommended storage conditions
Conditions to Avoid: Excessive heat, open flames, moisture, incompatible chemicals
Incompatible Materials: Strong oxidizers, acids, acid chlorides, acid anhydrides, bases
Hazardous Decomposition Products: Releases toxic gases including hydrogen chloride, carbon monoxide, carbon dioxide on decomposition
Polymerization: Not reported to occur under normal handling and storage
Acute Toxicity: Oral LD50 (rat): ~90 mg/kg; Dermal LD50 (rabbit): 422 mg/kg
Routes of Exposure: Absorption through skin, ingestion, inhalation
Symptoms of Exposure: Nausea, vomiting, abdominal pain, skin redness and blistering, severe eye irritation, headaches, respiratory distress
Chronic Effects: Possible carcinogen and genotoxin with long-term exposure; reproductive toxicity in animal studies
Sensitization: Not classified as a skin sensitizer in standard testing
Other Data: Causes mutagenic effects in vitro and in vivo studies; IARC classified as Group 2B (possible human carcinogen)
Ecotoxicity: Harmful to aquatic organisms; long-term effects in aquatic environments documented in studies
Persistence and Degradability: Expected to be biodegradable in the environment, though breakdown may produce toxic metabolites
Bioaccumulative Potential: Low potential based on partition coefficient
Mobility in Soil: Highly mobile in water, can leach into groundwater
Other Hazards: Avoid uncontrolled release to environment, as this chemical can disrupt local habitats
Waste Treatment Methods: Incineration preferred method under controlled conditions with proper emission scrubbing
Disposal of Contaminated Packaging: Rinse thoroughly, dispose of or recycle in accordance with local, regional, or national regulations
Special Precautions: Never discharge into sewers, surface water, or natural environments
Other Disposal Guidance: Consult hazardous waste specialist or local environmental authorities for advice
UN Number: 2810
UN Proper Shipping Name: Toxic Liquid, Organic, N.O.S. (3-Chloro-1,2-Propanediol)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Special Precautions for Transport: Use tightly sealed containers, label correctly, provide adequate documentation
Regulations: Subject to IMDG, IATA, DOT, ADR transport rules for toxic substances
Environmental Hazards: Marine pollutant under transport regulations; avoid release during handling and transport
Emergency Response Guide: Refer to current ERG guide for toxic organic liquids
OSHA: Chemical classified as hazardous; general workplace standards apply
TSCA: Listed in the US Toxic Substances Control Act inventory
SARA Title III: Not listed under Sections 302 or 313; be aware of reporting requirements for spills and releases
REACH (Europe): Subject to REACH restrictions; registration with ECHA required for use and manufacture
California Proposition 65: Listed as chemical known to the State of California to cause cancer
Other National/International Regulations: Classified as toxic and carcinogenic in Canada, EU, Japan; local policies and exposure limits may apply
Labelling Requirements: Hazard pictograms, warning phrases, supplier details on all packaging and containers
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