Safety Data Sheet for 3-Amino-1-propanol Hydrochloride

Identification

Chemical Name: 3-Amino-1-propanol hydrochloride
CAS Number: 5407-14-7
Synonyms: 3-Hydroxypropylamine hydrochloride, 3-Aminopropanol HCl
Recommended Use: Intermediate for chemical synthesis, laboratory reagent
Supplier: Manufacturer or distributor contact details placed here
Emergency Contact: Relevant local emergency number or Poison Center
Product Code: As specified by supplier

Hazard Identification

Classification: Eye irritation (Category 2), Skin irritation (Category 2), Acute toxicity oral (Category 4)
Signal Word: Warning
Pictogram: Exclamation mark (GHS07)
Hazard Statements: Causes skin irritation. Causes serious eye irritation. Harmful if swallowed.
Precautionary Statements: Wear protective gloves and eye protection. Do not eat, drink, or smoke while using product. Wash exposed skin after handling. Avoid release to environment.

Composition / Information on Ingredients

Chemical Formula: C3H9NO·HCl
Ingredient: 3-Amino-1-propanol hydrochloride
Concentration: >98% pure
Impurities: Trace amounts of starting materials and water (<0.5%)
Molecular Weight: 111.57 g/mol

First Aid Measures

Inhalation: Move affected person to fresh air, keep comfortable for breathing, seek medical advice if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, seek medical attention for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if possible, continue rinsing, consult ophthalmologist if discomfort remains
Ingestion: Rinse mouth, give water to drink, never induce vomiting, contact Poison Center or physician for guidance
Symptoms: Redness, irritation, burning sensation to eyes or skin, headache, nausea if ingested

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical powder, CO2, foam
Hazards in Fire: Thermal decomposition may release toxic fumes of hydrogen chloride, nitrogen oxides, carbon oxides
Protective Equipment: Wear full protective suit and self-contained breathing apparatus
Advice for Firefighters: Avoid breathing vapors, keep containers cool with water spray, prevent runoff into drains
Explosion Data: Not known to present explosion hazard

Accidental Release Measures

Personal Precautions: Use appropriate personal protective gear – gloves, goggles, and lab coat. Avoid contact with skin and eyes, provide adequate ventilation
Environmental Precautions: Prevent spillage from entering soil, waterways, or drains
Cleanup Methods: Sweep up and place in suitable container for disposal, ventilate area, wash spill site with water after material pick-up is complete

Handling and Storage

Safe Handling: Handle in well-ventilated areas, avoid dust generation, do not inhale dust, avoid prolonged or repetitive exposure
Storage Conditions: Keep container tightly closed, store in cool dry place, protect from light, store away from incompatible materials such as acids and oxidizers
Incompatible Materials: Strong oxidizing agents, strong acids, acid chlorides, acid anhydrides
Hygiene Practices: Wash thoroughly after use, do not eat or drink in work area, maintain good housekeeping

Exposure Controls and Personal Protection

Occupational Exposure Limits: Not established by OSHA, NIOSH, or ACGIH
Engineering Controls: Use fume hood or local exhaust ventilation to control dust
Protection for Skin: Protective gloves (nitrile or PVC), lab coat or chemical-resistant clothing
Eye Protection: Safety goggles or face shield
Respiratory Protection: Dust mask or respirator with P2 filter if dust is generated
Work Hygiene: Tidy workspace, regular cleaning, handwashing after use

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Mild, amine-like
pH (1% solution): Approx. 6-7
Melting Point: 188-190°C (decomposes)
Boiling Point: Not available (decomposes prior to boiling)
Solubility: Soluble in water, slightly soluble in ethanol
Vapor Pressure: Negligible at room temperature
Density: Approx. 1.05 g/cm³
Flash Point: Not flammable
Partition Coefficient (Log Pow): Not determined

Stability and Reactivity

Chemical Stability: Stable at room temperature, dries out when exposed to air
Reactivity: May react with strong acids or oxidizers
Hazardous Decomposition Products: Hydrogen chloride, carbon oxides, nitrogen oxides on decomposition
Polymerization: Not reported to occur
Incompatible Materials: Strong oxidizing agents, strong acids, acid chlorides

Toxicological Information

Acute Toxicity: Oral LD50 (rat): >300 mg/kg
Routes of Exposure: Inhalation, ingestion, skin/eye contact
Symptoms: Irritation to eyes, mucous membranes, skin; may cause nausea, headache, abdominal discomfort to those ingesting
Chronic Effects: No evidence of chronic toxicity, no documented carcinogenic, mutagenic, teratogenic effects for this compound in humans
Further Data: Not classified by IARC, NTP, OSHA with regard to carcinogenicity

Ecological Information

Ecotoxicity: No specific data, expected to have low toxicity based on chemical structure
Persistence and Degradability: Likely biodegradable in the environment
Bioaccumulative Potential: No significant bioaccumulation expected
Mobility in Soil: High solubility suggests some potential mobility, but rapid degradation predicted
Other Adverse Effects: Prevent release to waterways; large spills might temporarily raise pH or ammonia locally

Disposal Considerations

Waste Disposal Methods: Dispose as hazardous chemical waste; deliver to licensed chemical disposal contractor
Unclean Packaging: Triple rinse containers, dispose in accordance with local and national regulations
Contaminated Material: Treat as chemical waste; do not discharge to drains, soil, or unapproved landfill
Recycle Information: Recycling not practical for small lab-scale quantities; industrial-scale recycling guidance must comply with relevant regulations

Transport Information

UN Number: Not assigned
UN Proper Shipping Name: Not regulated as a dangerous good for transport
Transport Hazard Class: Not classified
Packing Group: Not applicable
Marine Pollutant: No
Special Transport Precautions: Secure packaging, protect from physical damage, ship in compliance with local laws

Regulatory Information

EU Regulations: Not specifically listed under REACH Annex XIV or SVHC
US Regulations: Not listed under SARA Title III, CERCLA, or TSCA inventory as hazardous
Labelling Requirements: GHS labeling with hazard pictograms required for workplace labeling
Workplace Control: COSHH regulation in the UK applies for lab handling; general duty of care for safe use in other regions
Other Regulatory Info: Not regulated under the Montreal Protocol, not subject to OSHA PSM, not a DEA-listed chemical