Material Safety Data Sheet for 3-(4-phenyl-1-piperazinyl)-1,2-propanediol

Identification

Product Name: 3-(4-phenyl-1-piperazinyl)-1,2-propanediol
Synonyms: N-Phenylpiperazine propanediol
Chemical Formula: C13H18N2O2
CAS Number: 303-26-4
Recommended Use: Laboratory chemical, research and development only
Producer Contact: Chemical supplier customer support, phone hotline, email support
Emergency Contact: Local poison control, national chemical emergency hotline
Address of Manufacturer: Listed on original packaging; consult supplier records

Hazard Identification

Classification: Harmful if swallowed, causes skin and eye irritation, may cause respiratory irritation
GHS Label Elements: Exclamation mark symbol for health hazard
Signal Word: Warning
Hazard Statements: Harmful if ingested; may cause moderate to severe skin and eye irritation; toxic if inhaled in significant concentrations
Precautionary Statements: Wear gloves, minimize dust, avoid inhalation, prevent eye contact, use proper ventilation, remove contaminated clothing after accidental exposure
Other Hazards: No reliable long-term studies on carcinogenic potential, mutagenicity, or reproductive effects; consult updated toxicological databases before large-scale use; chronic effects under research

Composition / Information on Ingredients

Chemical Identity: 3-(4-phenyl-1-piperazinyl)-1,2-propanediol
Concentration: Pure (≥98% as available from most suppliers)
Impurities: Trace piperazine derivatives, phenyl ring by-products, moisture possible depending on storage conditions
Ingredient List: 3-(4-phenyl-1-piperazinyl)-1,2-propanediol — main ingredient; minor contaminants below threshold regulated limits

First Aid Measures

Inhalation: Move affected person to fresh air at once, supply oxygen as needed, seek medical care if symptoms like coughing or dizziness persist
Skin Contact: Rinse exposed skin with running water for at least 15 minutes, remove contaminated clothing and wash before reuse, look for redness or itching
Eye Contact: Flush with water for several minutes, keep eyelids open, consult a physician right away
Ingestion: Rinse mouth, do not induce vomiting, watch for nausea or abdominal pain, seek emergency care immediately
Medical Attention: Have product label or MSDS available for medical staff, treat symptoms, monitor breathing and vital signs

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Unsuitable Media: Direct water jet if risk of powder dispersion
Specific Hazards: Toxic fumes or gases like nitrogen oxides, carbon oxides may form under combustion
Protective Equipment: Self-contained breathing apparatus, fire-resistant turnout gear, chemical-resistant gloves
Firefighting Procedures: Contain contaminated runoff, remove containers from fire area if safe, avoid inhaling combustion products, evacuate nearby premises

Accidental Release Measures

Personal Precautions: Wear respirator mask if dust disperses, goggles, impervious gloves, long sleeves
Environmental Precautions: Prevent entry to drains, surface water, or soil; report large spills to local authorities
Containment: Use inert absorbent (sand, vermiculite), ventilate area, sweep up with minimal dust
Cleanup Methods: Collect in sealable containers, label for chemical waste, decontaminate tools with mild detergent

Handling and Storage

Handling: Use in closed system or ventilated space, avoid direct contact with skin or eyes, don’t breathe dust, wear suitable PPE
Storage: Keep in tightly closed containers, cool and dry area, away from sunlight, segregate from strong acids, bases, oxidizers
Storage Temperature: Stable at 2–8 °C away from moisture
Packaging: Use properly labeled, chemical-resistant bottles, secondary containment for bulk storage

Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific country exposure limit established for this compound, consult workplace safety coordinator
Engineering Controls: Fume hood or local exhaust, closed systems for weighing and transfer
Personal Protection: Chemical splash goggles, gloves (nitrile or latex), lab coat, avoid synthetic fibers for explosive dust potential
Respirator: Use certified particulate mask if dusts exceed nuisance levels
Hygiene: Wash hands after handling, do not eat, drink, or smoke in the work area, remove PPE before leaving lab

Physical and Chemical Properties

Appearance: White to off-white powder or crystalline solid
Odor: Slightly musty or amine-like
Melting Point: 105–119 °C (literature sources)
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, ethanol
Relative Density: Approx. 1.15 g/cm³ (estimated)
pH: Neutral to slightly basic in solution
Vapor Pressure: Negligible at room temperature
Flash Point: Not determined, low volatility expected
Other Data: Stable under recommended storage, powder may form hazardous dust-air mixtures

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling
Reactivity: Incompatible with strong oxidizers, acids, bases; may hydrolyze under strong acid/base exposure
Decomposition: Emits hazardous fumes such as nitrogen oxides, carbon monoxide, carbon dioxide if degraded by heat
Polymerization: Not anticipated under normal conditions

Toxicological Information

Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Effects: Moderate to severe skin/eye irritation, digestive upset if swallowed, may cause sore throat or respiratory irritation
Chronic Effects: Data insufficient for cumulative effects, rare studies suggest caution until more toxicology results published
LD50 Values: Not fully established; some analogues report animal oral LD50 in the hundreds of mg/kg range
Sensitization: Low risk of allergic reaction based on chemical structure, but handle as potential irritant
Carcinogenicity/Mutagenicity: Not listed in IARC, NTP, or OSHA sources as of latest literature

Ecological Information

Ecotoxicity: No comprehensive data available, compound structure suggests risk to aquatic organisms if released
Mobility: Water-soluble, potential leaching into groundwater
Persistence and Degradability: Degradation expected to follow standard organic compound pathways, but specific rates unknown
Bioaccumulation: No evidence for high bioaccumulation, but phenyl group warrants caution for aquatic releases
Aquatic Toxicity: Avoid discharge to natural waters without proper treatment, possible persistent effects on invertebrates
Other Effects: No significant ozone depletion or greenhouse gas potential based on structure

Disposal Considerations

Disposal Methods: Send material and contaminated packaging to approved chemical waste facility
Incineration: Typical in chemical waste management, but follow state/province incinerator permit limitations
Avoid: Do not flush large amounts into drains or landfill, no unapproved local trash disposal
Container Disposal: Triple rinse, puncture if plastic before scrap disposal, label all containers with full chemical name
Consult: Local, regional, and national regulations before disposal

Transport Information

UN Number: Not classified or regulated as hazardous for ground, air, or sea transport in most countries
Proper Shipping Name: Not regulated; if mixed with other hazardous materials, follow combined shipping protocols
Transport Hazard Class: None assigned
Packing Group: None assigned, treat as chemical product
Special Precautions: Double-bag solid containers, keep upright, avoid moisture during transit, verify documentation matches shipping manifest
Transport Labels: Not required unless other hazardous constituents present

Regulatory Information

Safety, Health, Environmental Regulations: Not listed as controlled under EU REACH, US TSCA, or Canadian DSL/NDSL; local chemical reporting may differ
Other National Inventories: Check for updates in Asian and Latin American chemical control lists
Worker Protection: Subject to workplace chemical safety training, OSHA hazard communication standards where relevant
Labelling: Label all containers clearly with product name and hazard alert
REACH Status: No current SVHC status
Other Regulatory Notes: Single-use chemical, not for food, drug, or cosmetic manufacture