Product Name: (2R)-1-Chloro-2-propanol
Chemical Formula: C3H7ClO
Synonyms: (R)-1-chloro-2-hydroxypropane, (R)-2-hydroxy-1-chloropropane
CAS Number: 57090-45-6
Manufacturer: Supplier or distributor information to be included by purchaser.
Recommended Use: Laboratory chemical, intermediate in organic synthesis.
Restrictions: Not intended for food, drug, or household use.
GHS Classification: Acute Toxicity (Oral & Dermal) Category 4, Skin Irritation Category 2, Eye Damage Category 2A, Specific Target Organ Toxicity - Single Exposure Category 3, Flammable Liquids Category 3
GHS Pictograms: Flame, Exclamation Mark, Health hazard symbol
Signal Word: Warning
Hazard Statements: Harmful if swallowed or in contact with skin, causes skin and serious eye irritation, may cause respiratory tract irritation, flammable liquid and vapor.
Precautionary Statements: Avoid all contact with skin and eyes; keep away from heat, sparks, open flames; do not breathe mist or vapor; if inhaled, remove person to fresh air and keep comfortable; in case of contact, rinse immediately with plenty of water.
Chemical Identity: (2R)-1-Chloro-2-propanol
Purity: ≥98%
Impurities: Commercial-grade substances may contain minor organic by-products—consult batch-specific analysis.
Other Components: No stabilizers or additives present as standard; presence of water possible depending on storage.
Inhalation: Remove from exposure immediately. Move individual to fresh air, monitor for trouble breathing, give oxygen if needed, seek medical attention.
Skin Contact: Take off all contaminated clothing. Rinse skin with water or shower for at least 15 minutes. Get medical help if irritation persists.
Eye Contact: Rinse cautiously with water for several minutes, lifting eyelids. Remove contact lenses if present. Seek prompt medical advice.
Ingestion: Rinse mouth and drink water if conscious. Do not induce vomiting. Call a physician or poison center right away.
General Notes: Persons rendering aid should avoid exposure. Always seek follow-up care if symptoms develop or persist.
Suitable Extinguishing Media: Use alcohol-resistant foam, dry chemical, or carbon dioxide. Water may be ineffective for larger fires but can cool exposed containers.
Unsuitable Media: Avoid use of direct streams of water on burning material; this may spread fire.
Specific Hazards: Vapors form explosive mixtures with air. Combustion can give rise to toxic gases including hydrogen chloride, phosgene, carbon monoxide, and carbon dioxide.
Firefighting Equipment: Self-contained breathing apparatus and full protective clothing required.
Advice for Firefighters: Evacuate area, fight fire from upwind, avoid inhalation of combustion products, use caution with runoff as it may pose environmental risks.
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid breathing vapors, don chemical-resistant gloves, goggles, and lab coat.
Environmental Precautions: Prevent entry into drains, water sources, or soil. Notify local authorities in case of large spillage.
Containment: Use inert absorbent material, cover spills to reduce evaporation.
Cleanup Procedures: Collect spilled product with non-sparking tools and place in tightly closed chemical waste container. Wash remainder with plenty of water, ventilate area well.
Handling: Work under fume hood or with adequate ventilation. Use spark-proof tools and explosion-proof equipment. Avoid direct contact with skin, eyes, and clothing. Do not inhale vapor or mist. No smoking, open flames, or heat sources nearby.
Storage Conditions: Store in tightly sealed original container. Keep in cool, well-ventilated area, away from sunlight and incompatible substances, such as strong oxidizers and acids. Store at 2°C–8°C for stability.
Special Considerations: Use secondary containment, clear product labeling, routine inspection for leaks or damage.
Exposure Limit Values: No specific occupational exposure limits established. Keep exposure as low as reasonably achievable.
Engineering Controls: Work in chemical fume hood. Use spark-proof ventilation systems.
Personal Protective Equipment: Wear chemical splash goggles, nitrile gloves, lab coat, enclosed shoes. Use respirator (NIOSH/MSHA approved) if ventilation insufficient.
Hygiene Practices: Wash hands thoroughly after handling. Remove contaminated clothing, launder before reuse.
Appearance: Clear to pale yellow, oily liquid
Odor: Mild, somewhat sweet or alcoholic
Odor Threshold: Data not available
pH: Not applicable
Melting Point/Freezing Point: -50°C (approximate)
Boiling Point/Boiling Range: 127–130°C at 760 mmHg
Flash Point: 55°C (closed cup)
Evaporation Rate: Not established
Flammability: Flammable liquid
Explosive Limits: UEL/LEL data not available
Vapor Pressure: 11 mmHg at 25°C
Vapor Density: 2.4 (air = 1)
Relative Density: 1.17 g/cm³ at 20°C
Solubility: Miscible with water
Partition Coefficient: log Kow 0.68 (estimated)
Auto-ignition Temperature: 380°C
Decomposition Temperature: Not established
Viscosity: Not determined
Chemical Stability: Stable at standard room temperature and pressure under recommended storage.
Hazardous Reactions: Strong oxidizers, reducing agents, strong bases and acids can react vigorously with product. Can attack some plastics and rubbers.
Conditions to Avoid: Heat, flame, high temperatures, exposure to incompatible materials.
Decomposition Products: Hydrogen chloride, phosgene, carbon oxides in case of fire.
Acute Toxicity (Oral): LD50 (rat) 800–1200 mg/kg
Acute Toxicity (Dermal): LD50 (rabbit) >1200 mg/kg
Inhalation: Data insufficient; suspected respiratory irritant at elevated concentrations.
Skin Irritation: Causes irritation, possible redness and blistering on prolonged contact.
Eye Irritation: Severe irritation, risk of corneal injury.
Sensitization: No data on respiratory or skin sensitization.
Mutagenicity/Carcinogenicity: Not classified, but chlorinated alcohols may present long-term risks as indicated in animal studies.
Other Information: Repeated exposure can depress central nervous system, cause headache, nausea, or dizziness.
Aquatic Toxicity: Moderate toxicity to aquatic organisms expected, based on structurally similar materials.
Persistence and Degradability: Readily biodegradable but may present acute risk before degradation.
Bioaccumulative Potential: Low due to water solubility and log Kow.
Mobility in Soil: Highly mobile, potential to reach groundwater.
Other Adverse Effects: Avoid uncontrolled release. May contribute to environmental chemical load though rapid breakdown reduces persistence.
Waste Treatment Methods: Dispose of as hazardous organic waste via licensed chemical disposal contractor. Product and contaminated packaging not to enter drains, sewers, or water bodies.
Contaminated Packaging: Empty containers should be triple-rinsed. Dispose of as hazardous waste.
Other Disposal Notes: Consult local, regional, and national regulations. Do not attempt to neutralize or burn in open air.
UN Number: UN 1992
UN Proper Shipping Name: Flammable liquid, toxic, n.o.s. (contains (2R)-1-Chloro-2-propanol)
Transport Hazard Class: 3 (Flammable Liquids), 6.1 (Toxic Substances)
Packing Group: III
Marine Pollutant: Not regulated as a marine pollutant
Special Precautions for User: Keep away from heat and ignition sources. Secure loads during transport. Avoid package damage and leaks.
OSHA Status: Hazardous according to OSHA (29 CFR 1910.1200)
SARA Title III: No Section 302 or 313 reportable components
TSCA Inventory: Product must be reported if imported or manufactured in the U.S.
DSL (Canada): Consult Canada's NDSL/DSL listings.
EU Classification: Flammable, Harmful, Irritant (per CLP Regulation)
Label Elements: Flammable liquid and vapor, Harmful if swallowed or in contact with skin, Causes skin and serious eye irritation.
Other Regulations: Always check with national/local regulations since listings and hazard categories can change.
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