Chemical Name: 2-Propanol, 1-chloro-, (2R)-
Synonyms: (R)-1-Chloro-2-propanol, (R)-Chlorohydrin
CAS Number: 1545-13-1
Product Code: IPCL1545131R
Recommended Use: Intermediate in organic synthesis, specialty solvent
Supplier Details: Chemical manufacturer, industrial distributor; For emergencies, reach out to a chemical response hotline
GHS Classification: Flammable liquid, Acute toxicity (oral, dermal, inhalation), Skin and serious eye irritation, Specific target organ toxicity
Pictograms: Flame, Exclamation Mark, Health Hazard
Signal Word: Danger
Hazard Statements: Highly flammable, toxic if swallowed, can cause serious eye and respiratory irritation, adverse effects on central nervous system, risk of harmful vapor development
Precautionary Statements: Keep out of open flames, avoid breathing vapors, use in ventilated locations, wear safety goggles and gloves, no eating or drinking in handling area
Chemical Composition: 2-Propanol, 1-chloro-, (2R)- 98% minimum purity
Impurities: 2-Propanol, 1-chloro- (R,S) isomer <2%; moisture content <1%
Molecular Formula: C3H7ClO
Molecular Weight: 94.54 g/mol
Inhalation: Move to fresh air, maintain open airway, provide oxygen if breathing is labored. Seek medical care
Skin Contact: Remove contaminated clothing, wash exposed area thoroughly with soap and water. Rinse repeatedly in running water
Eye Contact: Rinse eyes for ten minutes under clean running water, lifting upper and lower eyelids frequently. If irritation, seek medical advice promptly
Ingestion: Rinse mouth; do not induce vomiting unless medical advice comes from poison control. Keep victim at rest while awaiting professional help
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, carbon dioxide. For small fires, use water mist only to cool containers
Unsuitable Media: Straight water jet may spread burning product; avoid
Specific Hazards: Combustion generates toxic gases, including HCl and phosgene in confined conditions. Explosive vapor-air mixtures possible in poorly ventilated places
Protective Equipment: Firefighters should wear breathing apparatus, chemical-resistant gear, gloves and boots, keep a safe distance, approach from upwind
Advice for Firefighters: Remove containers from fire exposure if possible, cool tanks with water spray to prevent bursting
Personal Precautions: Evacuate non-essential personnel, keep unprotected individuals away, ventilate area
Spill Cleanup: Absorb with inert, non-combustible absorbent (e.g. sand, earth), sweep up and transfer to well-sealed disposal containers, do not use sawdust or cellulose
Protection: Wear proper PPE: rubber gloves, eye/face protection, chemical-resistant apron
Environmental Precautions: Block entry to drains and surface water, prevent product from seeping into soil or groundwater
Methods of Disposal: Label cleanup material clearly, dispose through certified hazardous waste service
Safe Handling: Work in chemical fume hood or well-ventilated room, prevent formation of vapor cloud, ground all containers, ensure static discharge control, avoid contact with skin and eyes
Storage Requirements: Store in tightly closed containers, in a cool, dry, well-ventilated area away from direct sunlight and incompatible materials (strong oxidizers, acids, bases)
Special Precautions: Do not handle near open flames, heat, or hot surfaces, keep away from food, drink, and animal feed, maintain proper signage and restricted access
Shelf Life: Stable under recommended storage conditions for up to one year; monitor container pressure periodically
Occupational Exposure Limits: Engineering OEL: 5 ppm TWA; skin notation for potential dermal absorption
Engineering Controls: Local exhaust ventilation, explosion-proof equipment, eye-wash stations and safety showers mandatory
Personal Protective Equipment: Chemical splash goggles, nitrile gloves, full lab coat or disposable coveralls, vapor respirator (organic cartridge) when ventilation is not enough
Hygiene Measures: Wash hands, forearms, and face thoroughly after handling, remove contaminated clothing immediately, no smoking in use area
Appearance: Clear, colorless to pale yellow liquid
Odor: Faint, slightly sweet, halogenated alcohol
Odor Threshold: Detectable at low levels
pH: Not applicable
Melting Point/Freezing Point: -40°C (approximate)
Boiling Point/Range: 120–123°C
Flash Point: 38°C (closed cup), classified as flammable
Evaporation Rate: Moderate
Flammability: Flammable liquid and vapor
Upper/Lower Explosion Limits: Lower: ~2.0% vol, Upper: ~12% vol
Vapor Pressure: 18 mmHg at 20°C
Vapor Density: 3 (air = 1)
Relative Density: 1.09 g/cm³
Solubility: Miscible with water, alcohol; limited in hydrocarbons
Partition coefficient (n-octanol/water): log Kow ≈ 0.7
Auto-ignition Temperature: 390°C
Decomposition Temperature: Above 190°C
Viscosity: Thin liquid
Molecular Structure: Chiral secondary chloroalcohol
Chemical Stability: Remains stable under standard temperatures and atmospheric pressure
Reactivity: Reacts with strong oxidizing agents, alkaline materials, metals such as sodium or potassium (risk of violent reaction)
Conditions to Avoid: Elevated temperatures, static discharges, sources of ignition, prolonged exposure to moisture or light
Hazardous Decomposition Products: Hydrogen chloride, phosgene, carbon monoxide, carbon dioxide
Polymerization: No hazardous polymerization expected under normal handling
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Effects: Headache, dizziness, nausea, fatigue, central nervous system depression, respiratory irritation, gastrointestinal upset, severe eye and mucous membrane irritation
Chronic Effects: Prolonged exposure can affect liver and kidneys; repeated exposure increases risk of dermatitis and sensitization in some individuals
Toxicity Data: Oral LD50 (rat): ~120 mg/kg; Dermal LD50 (rabbit): >1100 mg/kg; Inhalation LC50 (rat, 4 hr): ~2600 ppm
Carcinogenicity/Mutagenicity: Not classified as a carcinogen by IARC, NTP, OSHA; evidence for mutagenicity inconclusive but caution advised
Reproductive Toxicity: Limited data; minimize exposure for all workers
Aquatic Toxicity: Toxic to aquatic life, LC50 (fish, 96 hr): 9-13 mg/L
Soil Mobility: Mobile in soil and leaches into groundwater quickly
Persistence and Degradability: Not readily biodegradable, persists in environment for weeks under anaerobic conditions
Bioaccumulation: Low; log Kow suggests minimal bioaccumulation potential
Other Impacts: May lead to groundwater contamination, disrupts aquatic processes at low concentrations; treat emissions and effluents before release
Waste Disposal: Incinerate at high temperature in permitted facility; do not flush to sewer; treat as hazardous chemical waste
Contaminated Packaging: Empty containers should be triple-rinsed, destroyed or taken by licensed handler, never reused
Precautions: Follow national, local regulations, use registered hazardous waste contractors
Disposal Code: US EPA RCRA U-listed hazardous waste
Proper Shipping Name: 2-Propanol, 1-chloro-, (2R)-
UN Number: UN2987
Hazard Class: 3 (Flammable liquid)
Packing Group: II
Labels Required: Flammable liquid, Toxic
Marine Pollutant: Classified as marine pollutant
Special Precautions: Keep containers upright, secure during transit, avoid shipment with oxidizers or alkalis, ensure quick access to MSDS for carriers
Safety, Health, Environmental Regulations: Subject to US OSHA, EPA, SARA Title III reporting, state and European REACH controls
Inventory Status: Listed under TSCA (US), EINECS (Europe), DSL (Canada)
Worker Safety: Covered by OSHA hazardous chemical standards, workers must receive safety training before exposure
Labeling Requirements: Pictograms, hazard and precautionary statements, supplier contact, batch number
Recordkeeping: Handlers must retain use and disposal logs for at least three years, report incidents immediately as required by national protocol
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