Product Name: 2-Chloro-2',4'-difluoroacetophenone
Chemical Formula: C8H5ClF2O
Synonyms: 2-Chloro-2,4-difluoroacetophenone, 1-(2,4-difluorophenyl)-2-chloroethanone
Recommended Use: Chemical research, laboratory reagent, intermediate for synthesis
Manufacturer: Reach out to reputable chemical suppliers
Contact Information: Emergency contact should be listed by supplier and local poison control center
CAS Number: 78807-61-1
UN Number: UN2811
EC Number: 282-651-9
Relevant Identified Uses: Laboratory testing, not for use in food, drug, or household products
Restrictions on Use: Any use outside professional laboratory environment restricted
Classification: Acute toxicity, Irritant to skin and eyes, Harmful by inhalation and if swallowed
Signal Word: Danger
Hazard Statements: Causes skin irritation; causes serious eye damage; toxic if inhaled or ingested; may cause respiratory irritation
Precautionary Statements: Avoid breathing dust, fumes, or vapors; wear protective gloves and eye protection; wash skin thoroughly after handling
Pictograms: Skull and crossbones, exclamation mark, corrosion
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Target Organs: Respiratory system, eyes, skin
Potential Health Effects: Burning sensation, coughing, shortness of breath, severe irritation, headache, nausea
Chemical Name: 2-Chloro-2',4'-difluoroacetophenone
Concentration: ≥98%
Impurities: Trace related organic compounds as declared by supplier, no hazardous non-disclosed ingredients
CAS Number: 78807-61-1
Inhalation: Move person to fresh air instantly, keep person at rest in a position comfortable for breathing, seek medical attention straight away; if not breathing, trained personnel should provide artificial respiration
Skin Contact: Wash with plenty of running water and mild soap for at least 15 minutes; remove contaminated clothing; seek medical attention if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing for not less than 15 minutes, get immediate medical attention
Ingestion: Do not induce vomiting; rinse mouth with water; never give anything by mouth to an unconscious person; get medical attention without delay
Most Important Symptoms: Severe eye irritation, skin redness, coughing, headache, dizziness, nausea, respiratory distress
Advice to Physician: Treat symptomatically, consider enhanced elimination in the event of large ingestion
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam
Unsuitable Extinguishing Media: Direct water jet may spread chemical
Specific Hazards: Emits toxic fumes of hydrogen chloride, phosgene, carbon oxides and hydrofluoric acid at elevated temperatures; containers may explode under fire conditions
Protective Equipment for Firefighters: Self-contained breathing apparatus (SCBA), full protective clothing including chemical resistant gloves and boots
Special Precautions: Avoid breathing smoke or vapors, cool containers exposed to flames with water spray from a safe distance, evacuate area as appropriate
Explosion Data: No specific sensitivity to static or impact noted but take care with heat and contamination
Personal Precautions: Evacuate non-essential personnel, ventilate area, avoid contact with skin, eyes, and clothing; wear appropriate personal protective equipment (PPE) including gloves, goggles, and respirator
Environmental Precautions: Prevent further leakage or spillage if safe to do so; do not flush to sewer or waterway; contain spill with absorbent non-combustible material
Cleanup Methods: Pick up with inert, absorbent material such as vermiculite or sand; place into labeled waste container for disposal according to local regulations
Decontamination: Wash residue away using water after pickups; ventilate area and check air quality before re-entry
Safe Handling: Use only in well-ventilated chemical fume hoods; avoid creating dust or aerosols; avoid inhalation and direct contact; keep containers closed when not using
Hygiene Requirements: Wash hands thoroughly after handling; change contaminated clothing; separate eating and drinking areas from handling area
Storage Conditions: Store in a tightly closed container, in a cool, dry place, away from sources of ignition, heat, direct sunlight, oxidizing agents, acids, bases
Segregation: Keep away from incompatible materials such as strong oxidizers and strong acids
Engineering Controls: Work in fume hood with exhaust, provide eye-wash stations and safety showers near work area
Respiratory Protection: Use a properly fitted NIOSH-approved respirator if airborne exposures exceed recommended limits or during spill cleanups
Eye Protection: Wear chemical splash goggles and, where risk of splashing exists, face shield
Skin Protection: Wear chemical-resistant gloves (nitrile or equivalent), lab coat, long sleeves, closed-toe shoes, and chemical-resistant apron if handling large quantities
Other Protective Equipment: Use barrier cream and impervious clothing when required
Exposure Limits: No established OSHA or ACGIH exposure limits; minimize exposure as much as possible
Appearance: Pale yellow liquid or crystalline solid depending on temperature and purity
Odor: Sharp, acrid
Odor Threshold: Not established
pH: Not applicable (non-aqueous)
Melting Point: 28–31 °C
Boiling Point: Around 140–150 °C at reduced pressure
Flash Point: 79 °C (closed cup, approximate)
Evaporation Rate: Not available
Flammability: Not classified as highly flammable, but combustible
Upper/Lower Flammability Limits: Not determined
Vapor Pressure: Not available
Vapor Density: Not available
Relative Density: Around 1.35–1.40 g/cm3
Solubility: Slightly soluble in water; soluble in most organic solvents such as ethanol, acetone, ether
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not known
Viscosity: Not available
Chemical Stability: Stable under normal conditions with adequate ventilation
Reactivity: Reacts with strong bases, acids, and oxidizers with possible hazardous decomposition
Incompatible Materials: Strong alkalis, strong acids, oxidizing agents, strong reducing agents, water (on heating)
Hazardous Decomposition Products: Hydrogen chloride, hydrogen fluoride, carbon oxides, phosgene possible at high temperatures
Polymerization: No risk of hazardous polymerization under recommended storage and handling
Acute Toxicity: Toxic if ingested, inhaled, or absorbed via skin; LD50 values for rat (oral): about 150–300 mg/kg; data limited and may vary
Chronic Effects: No data on chronic toxicity; frequent exposure may cause sensitization or long-term organ effects
Corrosivity/Irritation: Causes eye burns, skin irritation, severe respiratory tract irritation
Carcinogenicity: Not classified as human carcinogen by IARC, ACGIH, NTP, OSHA
Mutagenicity/Teratogenicity: No data available
Other Potential Effects: Severe irritation, lung edema, headache, dizziness, gastrointestinal symptoms if ingested or inhaled
Toxicity: May prove harmful or toxic to aquatic and terrestrial organisms if released in significant quantities; data on LC50, EC50 not available
Persistence/Degradability: Limited data; may not quickly degrade in the environment, potential for persistence
Bioaccumulative Potential: No significant bioaccumulation expected based on structure, but not confirmed
Mobility in Soil: Likely to be partially mobile; water solubility is low
Other Adverse Effects: Avoid release to environment; small spills should be cleaned up and disposed as hazardous waste
Disposal Methods: Collect and dispose of as hazardous chemical waste, in accordance with federal, state, and local requirements; never pour down drain
Contaminated Packaging: Dispose of empty containers in the same manner as product unless thoroughly cleaned and confirmed decontaminated
Special Precautions: Consult with certified waste management professionals or local environmental authorities for suitable incineration or chemical neutralization procedures
RCRA Hazardous Waste Code: Not specifically assigned; likely falls under U or P listed waste for halogenated ketones
UN Number: UN2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (2-Chloro-2',4'-difluoroacetophenone)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Hazard Labels: Toxic (Skull and Crossbones)
Special Precautions for User: Limit exposure, transport securely, follow all regulatory and carrier requirements
Environmental Hazards: Not classified as marine pollutant, but prevent spills
Transport in Bulk: Not intended for bulk shipping
DOT, IATA, IMDG Requirements: All standard toxic substance regulations apply; shipper must declare appropriately and use overpack where required
OSHA Status: Hazardous under OSHA regulations
TSCA Status: Substance listed or specifically regulated under Toxic Substances Control Act
SARA Title III (Sections 311/312 Hazard Categories): Acute Health Hazard
SARA Title III (Section 313): Not listed
State and Local Regulations: May appear under hazardous chemical listings for workplace and environmental safety; consult local codes
International Regulations: Classification and labeling according to the Globally Harmonized System (GHS); EU REACH requirements may apply for research, distribution, or import
Labelling Requirements: All containers must clearly state chemical name and hazard warnings according to national and international law
Other Requirements: Report significant spills to relevant authorities; track inventory and employee exposures in laboratories using written procedures
Providing high-quality chemical products and logistics solutions for global trade partners.
