Product Name: 2-Amino-5-chloro-2'-fluorobenzophenone
Chemical Formula: C13H9ClFNO
CAS Number: 142227-57-6
Synonyms: 5-Chloro-2-(2-fluorobenzoyl)aniline
Recommended Use: Research and chemical synthesis
Supplier: Chemical distributors and laboratories hold detailed records; always check documentation for local supplier and emergency numbers.
GHS Classification: Acute toxicity (oral, dermal, inhalation), Eye irritation, Skin irritation
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled, Causes skin and eye irritation, May cause respiratory irritation
Pictogram: Exclamation mark
Precautionary Statements: Avoid breathing dust or vapors, Wash hands after handling, Use only outdoors or in well-ventilated areas, Wear protective gloves and eye protection, Call poison center if you feel unwell.
Chemical Name: 2-Amino-5-chloro-2'-fluorobenzophenone
Concentration: ≥ 98%
Impurities or Stabilizing Additives: Traces of related benzophenone derivatives, less than 2% combined
Molecular Weight: 249.67 g/mol
Eye Contact: Rinse carefully for several minutes with plenty of water, seek medical advice if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water
Inhalation: Move to fresh air, get immediate medical attention for persistent cough or breathing difficulty
Ingestion: Rinse mouth, contact medical professional, avoid inducing vomiting unless advised
Symptoms: May include irritation, headache, nausea, drowsiness, redness, and swelling.
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water spray
Unsuitable Media: Do not use direct water stream
Specific Hazards: Combustion produces toxic gases (HCl, HF, Nitrogen oxides, Carbon oxides), burning causes dense smoke
Protective Equipment: Self-contained breathing apparatus, full protective gear, avoid inhaling fumes
Advice for Firefighters: Control run-off, stay upwind, use caution near containers exposed to fire.
Personal Precautions: Evacuate unnecessary personnel, ventilate area, wear gloves, goggles, mask
Environmental Precautions: Avoid discharge to drains, sewers, soil, or surface waters
Cleanup Methods: Scoop up with inert material (sand, vermiculite), place in appropriate container, secure for disposal
Avoidance: Do not generate dust or aerosols, minimize spread, report large spills to local authorities.
Handling: Handle inside chemical fume hood, use personal protective equipment, avoid getting on skin or in eyes, do not breathe dust
Storage: Keep in tightly closed original container, store away from light, moisture, and incompatible materials (oxidizing agents)
Safe Practices: Label containers clearly, restrict access to authorized trained staff, keep away from food and drink, maintain temperature 2–8°C.
Engineering Controls: Local exhaust ventilation, eyewash stations, safety showers in workspace
Personal Protective Equipment (PPE): Lab coat, chemical-resistant gloves (nitrile), safety goggles, NIOSH-approved respirator for powders or dust
Hygiene Measures: Wash hands before breaks and after work, keep clothing and equipment clean
Environmental Controls: Use closed systems, minimize airborne dust, ensure disposal by trained staff.
Appearance: Off-white to yellowish crystalline powder
Odor: Slight, characteristic aromatic
Odor Threshold: Not established
pH: Not determined
Melting Point: 121–124°C
Boiling Point: Not measured (decomposes)
Flash Point: >110°C (closed cup estimate)
Evaporation Rate: Negligible
Flammability: Not highly flammable
Vapor Pressure: Very low at room temperature
Solubility: Slightly soluble in water, soluble in common organic solvents (DMSO, methanol, ethanol)
Partition Coefficient (log Kow): Not available
Vapor Density: Not established
Density: Approx. 1.33–1.36 g/cm³
Decomposition Temperature: >200°C
Viscosity: Not applicable (solid)
Chemical Stability: Stable under normal conditions, avoid excess moisture and heat
Reactivity: Unreactive towards most materials under standard lab conditions
Conditions to Avoid: Excess heat, prolonged exposure to air, direct sunlight
Incompatible Materials: Strong oxidizing agents, strong acids or bases
Hazardous Decomposition: Hydrogen chloride, hydrogen fluoride, nitrogen oxides, carbon monoxide, carbon dioxide
Routes of Exposure: Inhalation, ingestion, dermal, ocular
Acute Toxicity: Swallowing may cause nausea, vomiting, abdominal pain, respiratory exposure brings coughing, dizziness
Skin Sensitization: Prolonged or repeated contact causes irritant dermatitis
Eye Effects: Irritation, tearing, redness
Chronic Effects: Not fully researched, avoid unnecessary repeated exposure, no known carcinogenicity
LD50 (estimated oral, rat): ~300–500 mg/kg
Mutagenicity/Carcinogenicity: Insufficient data, long-term testing lacking, recommended to avoid chronic exposure
Ecotoxicity: Toxic to fish and aquatic life at high concentrations, chronic low-dose effects unstudied
Mobility: Non-volatile, low mobility in soil, may accumulate
Persistence and Degradability: Stable under normal environmental conditions, possible slow degradation
Bioaccumulation Potential: Unknown, but aromatic ketones typically show moderate potential
Other Effects: Avoid environmental release, chemical safety strongly recommended at all stages.
Waste Treatment: Collect residue in sealed, labelled chemical waste containers
Disposal Methods: Send to licensed hazardous waste facility, incineration recommended under controlled conditions
Special Precautions: Do not dispose of via regular sewage or municipal waste systems
Empty Container Handling: Treat as hazardous, triple rinse then manage as regulated waste
UN Number: Not listed under UN hazardous substances
Transport Hazard Class: Not classified as dangerous for road, air, or sea (consult current regulations)
Packing Group: Not regulated but package securely
Proper Shipping Name: Chemical, not otherwise specified
Environmental Hazards: Transport away from food and feed, avoid exposure to environment during transportation
Special Precautions: Use spill-proof packaging, declare as laboratory chemical if required, ensure MSDS accompanies shipment
OSHA Status: Not specifically regulated, consult local standard interpretation
TSCA: Listed or exempted
REACH (EU): Registration status can vary; low-volume labs should confirm compliance
SARA Title III: Not a listed extremely hazardous substance
California Prop 65: Not listed
Other Regulations: Must always follow workplace chemical safety codes, labeling, and exposure standards; workers require access to safety sheets and training for safe handling and response.
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