Product Name: 2-Amino-2-Hydroxymethyl-1,3-Propanediol
Synonyms: Tris(hydroxymethyl)aminomethane, Tris base, Trometamol, Trizma
Chemical Formula: C4H11NO3
Molecular Weight: 121.14 g/mol
CAS Number: 77-86-1
Recommended Use: Laboratory reagent, biological buffer, pharmaceutical applications
Manufacturer/Supplier: Refer to label or purchase documentation for contact details, emergency phone, technical support
GHS Classification: Not classified as a hazardous substance under OSHA regulations, but can irritate eyes, skin, and respiratory tract
Label Elements: No pictogram required; precautionary statements advised
Health Hazards: Causes mild skin and eye irritation, dust may cause coughing or sneezing
Environmental Hazards: Minor risk, but should be kept out of waterways
Specific Risks: Inhalation of dust can cause discomfort, ingestion in large quantities can cause nausea
Precautionary Statements: Avoid breathing dust, wash thoroughly after handling, wear protective gloves, avoid direct contact with eyes and skin
Chemical Name: 2-Amino-2-Hydroxymethyl-1,3-Propanediol
Percent Composition: 99-100% pure, trace contaminants possible
Impurities: No significant impurities expected in analytical grade material
Hazardous Ingredients: No components present at concentrations above cutoff values considered hazardous
Inhalation: Move to fresh air, support breathing as needed, seek medical attention for persistent symptoms
Skin Contact: Rinse skin with plenty of water, remove contaminated clothing
Eye Contact: Immediately flush eyes with water for fifteen minutes, seek medical attention if discomfort continues
Ingestion: Rinse mouth with water, never give anything by mouth if unconscious, seek medical advice if large amount swallowed
Notes for Physicians: Treat symptomatically; basic decontamination usually sufficient
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, foam
Specific Hazards from Fire: Emits toxic fumes under fire conditions including nitrogen oxides and carbon oxides
Protective Equipment for Firefighters: Use full protective clothing and self-contained breathing apparatus
Fire or Explosion Risk: Product is not flammable, but packaging may burn; avoid inhaling combustion gases
Personal Precautions: Use personal protective equipment, avoid stirring up dust, ventilate the area
Environmental Precautions: Prevent release into drains, surface water, and soil
Methods for Cleanup: Sweep up, collect in suitable container for disposal, clean area with water after removal
Reporting: Local regulations may require notification for large spills
Safe Handling: Use with adequate ventilation, minimize dust creation, avoid ingestion and direct contact
Hygiene Practices: Wash hands thoroughly after handling, do not eat, drink, or smoke in work area
Storage Requirements: Store in tightly closed containers, keep in cool and dry location, away from acids and strong oxidizers
Incompatible Materials: Avoid storing with strong acids, strong oxidizing agents
Exposure Limits: No specific occupational exposure limits established
Engineering Controls: Use local exhaust ventilation or general room ventilation
Personal Protection: Wear safety goggles, gloves resistant to chemicals, lab coat; for dusty operations use a particulate respirator
Environmental Controls: Avoid discharging waste into the environment, use containment for spill response
Appearance: White crystalline powder
Odor: Odorless
Melting Point: 168-172°C
Boiling Point: Decomposes
Solubility: Highly soluble in water
pH (1% solution): Approximately 10.4–10.8
Relative Density: 1.33 g/cm³
Vapor Pressure: Negligible at room temperature
Partition Coefficient: Log Pow -3.3
Other Properties: Non-volatile, stable under standard conditions, low odor threshold
Chemical Stability: Stable under normal temperatures and pressures
Possibility of Hazardous Reactions: Reacts with strong acids to form salts, can generate hazardous gases with nitrites
Conditions to Avoid: Humidity, exposure to strong oxidizers and acids, extreme heat
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides on thermal decomposition
Polymerization: Will not occur under normal handling
Likely Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Acute Effects: Irritation to eyes, skin, respiratory tract; large doses may cause gastrointestinal discomfort
Chronic Effects: No evidence of long-term toxicity with proper laboratory use
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA
Mutagenicity: No data indicating genetic toxicity
Reproductive Toxicity: No evidence from published literature
Sensitization: Rarely reported as a sensitizer
LD50 (Oral, Rat): > 5,000 mg/kg
Other Data: Not considered highly toxic, but best practice is to avoid unnecessary exposure
Ecotoxicity: Low toxicity to aquatic organisms, but avoid release in large quantities
Persistence and Degradability: Expected to be biodegradable, breaks down in the environment
Bioaccumulation: Not likely to accumulate in biota
Mobility in Soil: High solubility leads to mobility in water, but low environmental concern
Other Adverse Effects: No significant ozone depletion, photochemical or greenhouse gas potential
Waste Disposal: Dispose of in accordance with local, state, and national regulations, prefers controlled incineration or landfill
Container Disposal: Rinse containers, dispose as non-hazardous waste if decontaminated
Special Considerations: Reuse and recycle where possible, minimize material sent to landfill
UN Number: Not regulated for transport
Proper Shipping Name: Not hazardous as per current transport regulations
Transport Hazard Class: Not classified
Packing Group: Not assigned
Environmental Hazards: Not considered a marine pollutant
Special Precautions: Prevent package breakage during handling and transport
TSCA Status: Listed in the TSCA Inventory
REACH: Registered for production and import in the European Union
SARA Title III: Not subject to reporting under SARA Title III Section 313
California Prop 65: Not listed
Other Regional Regulations: Product complies with chemical safety reporting requirements in North America and Europe, label per GHS requirements in applicable regions
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