Material Safety Data Sheet: 2-Amino-1,3-propanediol

Identification

Product Name: 2-Amino-1,3-propanediol
Synonyms: Serinol; 1,3-Dihydroxy-2-aminopropane
CAS Number: 534-03-2
Recommended Use: Laboratory research, chemical synthesis
Manufacturer/Supplier: Emergency contact information as provided by supplier on product label
Contact Numbers: Accessible through product-specific documentation
Emergency Phone: National Poison Control or supplier emergency hotline

Hazard Identification

GHS Classification: Harmful if swallowed (Acute Toxicity Category 4), causes skin irritation (Category 2), causes serious eye irritation (Category 2A)
Signal Word: Warning
Hazard Statements: May cause moderate skin irritation, may cause eye injury or discomfort, harmful if taken internally
Pictograms: Exclamation mark
Precautionary Statements: Wear safety glasses, protective gloves, avoid eating, drinking, or smoking while handling material
Potential Health Effects: Inhalation and ingestion may lead to symptoms such as headache, abdominal pain, or nausea. Prolonged or repeated exposure to vapors, dust, or liquid can cause dermatitis or respiratory discomfort

Composition / Information on Ingredients

Chemical Name: 2-Amino-1,3-propanediol
Concentration: ≥98% by weight
CAS Number: 534-03-2
Impurities/Byproducts: Trace levels of unreacted starting materials, water, residual solvents from synthesis, if any
Description: Solid, typically powder or crystalline, sometimes forms a viscous liquid under certain temperature or humidity

First Aid Measures

Inhalation: Remove person to fresh air, monitor for breathing difficulty, seek medical attention for persistent symptoms
Skin Contact: Wash with soap and plenty of water for at least 15 minutes, remove contaminated clothing, call a physician if irritation persists
Eye Contact: Rinse cautiously with water for at least 15 minutes, lift upper and lower eyelids occasionally, get immediate medical advice
Ingestion: Rinse mouth, do not induce vomiting, give water if person is conscious, seek medical attention promptly
General Advice: Always consult healthcare professionals even for minor exposures, bring product container or safety data when seeking help

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, carbon dioxide, alcohol foam, or water spray for small fires
Unsuitable Media: Direct water jet may spread burning material
Special Hazards: May produce toxic fumes such as nitrogen oxides, carbon monoxide under fire conditions
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Advice for Responders: Fight fire from safe distance, prevent run-off water from entering drains or water courses

Accidental Release Measures

Personal Precautions: Use adequate ventilation, avoid dust formation, avoid breathing vapors or dust, ensure use of personal protective equipment including gloves and eye protection
Environmental Precautions: Do not let the product enter drains, surface or ground water
Spill Clean-up: Collect material mechanically, place in suitable, labelled containers for disposal, wash spill site after material pick-up is complete, dispose contaminated materials as hazardous waste
Emergency Procedures: Evacuate area, limit access until clean-up complete

Handling and Storage

Safe Handling: Avoid contact with skin, eyes, and clothing, wash hands after handling, keep containers tightly closed when not in use, handle in well-ventilated areas
Conditions for Safe Storage: Store in a cool, dry place, keep away from incompatible substances like strong oxidizers or acids, use corrosion-resistant containers with secure lids
Incompatibilities: Avoid contact with strong oxidizing agents, strong acids, anhydrides
Storage Recommendations: Clearly label storage containers, inspect regularly for signs of leaks, degradation or cloudiness, segregate from food and drink

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established occupational exposure limit values from OSHA, NIOSH, or ACGIH
Engineering Controls: Use local exhaust ventilation or fume hoods to keep airborne levels low
Personal Protective Equipment: Wear protective laboratory gloves (nitrile, neoprene), chemical splash goggles, lab coat and closed footwear
Respiratory Protection: Use approved respirator if workplace levels exceed recommended exposure or in absence of adequate ventilation
Hygiene Measures: Wash hands and face before breaks, after handling chemicals, remove contaminated clothing before entering clean areas

Physical and Chemical Properties

Appearance: White crystalline solid or colorless viscous liquid
Odor: Faint ammonia-like
pH: Approximately 10 in 10% solution
Melting Point: 45-49°C
Boiling Point: 218-220°C at atmospheric pressure
Flash Point: Not easily flammable, no significant flash point under normal handling
Solubility: Highly soluble in water, partially soluble in lower alcohols, not soluble in hydrocarbons
Density: 1.12 g/cm³ at 20°C
Vapor Pressure: Negligible at room temperature
Viscosity: Viscous in liquid form
Decomposition Temperature: Above 230°C, may release toxic fumes

Stability and Reactivity

Stability: Stable under recommended storage conditions, avoid excessive heat and moisture
Reactivity: No dangerous reactions known under normal conditions
Polymerization: Not known to polymerize spontaneously
Conditions to Avoid: High temperatures, strong acids or oxidizers, direct sunlight
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide may form on heating or combustion

Toxicological Information

Acute Toxicity: LD50 (oral, rat) ~4000 mg/kg; relatively low, but ingestion may still cause harmful effects
Skin Corrosion/Irritation: May cause irritation on prolonged exposure
Eye Damage/Irritation: Risk of serious eye irritation, redness, blurred vision
Respiratory or Skin Sensitization: Not classified as a respiratory or skin sensitizer by GHS
Long-Term Effects: No known evidence of mutagenicity or carcinogenicity based on available animal studies
Other Effects: Chronic exposure may aggravate existing skin conditions

Ecological Information

Ecotoxicity: Harmful to aquatic life at very high concentrations
Persistence and Degradability: Expected to be readily biodegradable in the wider environment
Bioaccumulation: Potential for bioaccumulation considered low based on structure and physical properties
Mobility in Soil: High solubility in water suggests significant soil mobility
Other Adverse Effects: Avoid release into natural bodies of water, runoff may alter local pH

Disposal Considerations

Waste Treatment Methods: Dispose of in accordance with local, regional, and national regulations
Chemical Waste: Collect in sealed, labelled containers, treat as hazardous chemical waste
Contaminated Packaging: Triple rinse containers, destroy after use or dispose through certified handler
Precautions: Avoid disposal into the environment, prevent spills from reaching drains

Transport Information

UN Number: Not classified as a hazardous material for transport by DOT, IATA, or IMDG
Proper Shipping Name: 2-Amino-1,3-propanediol
Transport Hazard Class: Not regulated as dangerous goods
Packing Group: None assigned
Special Precautions: Secure packaging, avoid breakage and exposure during transit

Regulatory Information

Inventory Listings: Listed in TSCA (USA), EINECS (Europe), DSL (Canada)
OSHA: Not classified as a hazardous substance under OSHA Hazard Communication Standard
SARA Title III: Not listed as hazardous under Section 302, 304, or 313
California Proposition 65: Not listed
Other Regulations: Ensure compliance with REACH (EU), WHMIS (Canada), and any additional local requirements