MSDS for 2-[(Acetyloxy)methoxy]-1,3-propanediol diacetate

Identification

Product Name: 2-[(Acetyloxy)methoxy]-1,3-propanediol diacetate
Synonyms: Glycerol 1,3-diacetate 2-acetyloxymethyl ether
Chemical Family: Organic ester
Recommended Uses: Laboratory and industrial solvent, chemical intermediate
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UN Number: Not regulated under standard UN shipping

Hazard Identification

Hazard Classification: Eye irritant, skin irritant, potential respiratory irritant on excessive inhalation
Signal Word: Warning
Hazard Statements: Causes mild skin irritation, may cause serious eye irritation, can cause respiratory discomfort if inhaled as mist or vapor
Precautionary Statements: Avoid breathing mist or vapor, wash thoroughly after handling, wear protective gloves, clothing, and eye/face protection, use only outdoors or in well-ventilated areas
Pictograms: Exclamation mark for skin and eye irritation
Unknown Toxicity: No data for full mixture; based on ingredient structure innate toxicity is considered low according to publicly available datasets
Target Organs: Eyes, skin, respiratory system

Composition / Information on Ingredients

Chemical Name: 2-[(Acetyloxy)methoxy]-1,3-propanediol diacetate
Purity: Minimum 95% by weight
Other Ingredients: Trace moisture, trace acetic acid, synthesis residues below 1%
Hazardous Components: No regulated hazardous constituents above threshold requiring identification

First Aid Measures

Inhalation: Move individual to fresh air, keep person comfortable, monitor breathing, seek medical attention when symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin with plenty of soap and water, seek attention for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing, seek prompt medical help if irritation remains
Ingestion: Rinse mouth, do not induce vomiting, watch for signs of discomfort, seek medical advice immediately
Most Important Symptoms: Redness, itching or swelling on skin, stinging or redness in eyes, respiratory irritation
Immediate Medical Attention: Eye exposure may require rapid specialist consultation

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: Direct high-pressure water streams due to potential splatter
Hazardous Combustion Products: Releases carbon monoxide, carbon dioxide, acetic acid fumes under fire conditions
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective suit
Special Precautions: Prevent runoff from fire control from entering drains or surface waters
Fire/Explosion Hazards: Combustible at elevated temperature, vapors may form explosive mixtures with air if heated well above ambient

Accidental Release Measures

Personal Precautions: Ventilate area, evacuate unnecessary personnel
Protective Equipment: Chemical resistant gloves, safety goggles, coveralls, respirator when mist may become airborne
Spill Containment: Stop leak if safe to do so, dike large spills, prevent entry into drains, sewers, watercourses
Clean-Up Methods: Absorb with inert material (sand, diatomite), place in sealable container for proper disposal
Environmental Precautions: Prevent spills from reaching soil and waterways

Handling and Storage

Handling: Use only in well-ventilated areas, avoid skin and eye contact, avoid inhalation of vapors or mists, keep away from incompatible materials like strong alkalis, oxidizers
Hygiene Measures: Wash hands before eating, drinking or smoking, remove contaminated clothing and laundry thoroughly before reuse
Storage Conditions: Store in tightly-closed containers, in a cool, dry, well-ventilated area, away from heat sources and direct sunlight
Incompatibles: Avoid strong acids, alkalis, and oxidizing agents which cause decomposition or violent reaction
Other Precautions: Keep container upright, avoid handling in confined unventilated spaces

Exposure Controls and Personal Protection

Exposure Limits: No established workplace exposure limits found for this compound, monitor for acetic acid vapor as secondary decomposition hazard
Engineering Controls: Good general ventilation, local exhaust at points of emission
Eye Protection: Chemical splash-proof goggles, face shield for bulk handling
Skin Protection: Impermeable gloves (nitrile or neoprene), chemical-resistant apron
Respiratory Protection: Organic vapor respirator if vapor or aerosol concentration exceeds comfort level
Environmental Exposure Measures: Minimize airborne emissions, avoid release to environment, apply workplace containment where applicable

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Mild acetic ester odor
pH: Not applicable (non-aqueous)
Melting Point: Below room temperature
Boiling Point: Decomposes above 200°C, no clear boiling point
Flash Point: Estimated 110°C (closed cup)
Evaporation Rate: Slower than diethyl ether
Flammability: Low flammability, but combustible at high temperature
Vapor Pressure: Low at room temperature
Solubility: Moderately soluble in water, freely soluble in most organic solvents
Density: Roughly 1.18 g/cm³ at 20°C
Viscosity: Slightly more viscous than water
Partition Coefficient (n-octanol/water): Estimated moderate, reflecting ester content

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Decomposition: Yields acetic acid and formaldehyde under prolonged heating or strong acid/base contact
Conditions to Avoid: Heating above boiling point, exposure to strong bases, acids, powerful oxidizing agents
Incompatible Materials: Alkali metals, strong acids, bases, oxidizers
Hazardous Reactions: May react exothermically with above materials, releases decomposition gases if heated to high temperatures
Polymerization: Not known to undergo hazardous polymerization

Toxicological Information

Acute Toxicity: Expected low toxicity based on related esters, oral LD50 anticipated >2000 mg/kg (rat)
Skin Corrosion/Irritation: Causes mild to moderate irritation, severity depends on duration and exposure
Eye Damage/Irritation: May cause serious eye irritation on contact
Respiratory Sensitization: Irritation possible if vapor or mist concentrations exceed normal air-dilution rates
Skin Sensitization: Not expected, but avoid repeated prolonged exposure
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity/Teratogenicity: No conclusive data available
Chronic Effects: Prolonged or repeated contact may cause dermatitis or respiratory discomfort

Ecological Information

Aquatic Toxicity: Not acutely toxic at low levels, but high concentrations may cause harm to aquatic invertebrates
Persistence and Degradability: Expected to undergo biodegradation through ester hydrolysis in environment
Bioaccumulation Potential: Estimated low to moderate, based on partition coefficient
Mobility in Soil: Intermediate mobility, not expected to strongly bind to soil particles
Other Adverse Effects: Large spills can deplete oxygen levels in water, cause pH shifts due to acetic acid formation

Disposal Considerations

Waste Treatment Methods: Utilize licensed waste disposal company, incinerate with appropriate emission control
Disposal of Product: Incineration or solvent recovery recommended
Waste Codes: Check with local environmental authority; not listed as a hazardous waste federally in most jurisdictions
Contaminated Packaging: Triple rinse, puncture, dispose of in authorized landfill or via incineration
Precautions: Do not discharge to sewers or watercourses, keep out of landfill unless authorized

Transport Information

UN Number: Not classified as dangerous goods for land, sea or air transport
Proper Shipping Name: Not regulated for transport
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Environmental Hazards: None under normal transport conditions
Special Precautions for Users: Secure loads, avoid temperature extremes, contain leaks
Transport in Bulk: Not regulated for MARPOL/IBC

Regulatory Information

TSCA: Registered or exempt
REACH: Pre-registered or registered as appropriate
OSHA Classification: Not hazardous under OSHA Hazard Communication Standard
SARA Title III: Not listed Section 302/304 (EHS), Section 313 (TRI)
California Prop 65: Not listed
WHMIS Classification (Canada): Not controlled
Other Inventory Listings: Verify with national chemical inventories as applicable
Labeling Requirements: Eye/skin irritant symbols as outlined in hazard identification