Chemical Name: 2,2-Difluoro-1,3-propanediol
Synonyms: Difluoropropanediol; 1,3-Propanediol, 2,2-difluoro-
CAS Number: 359-98-4
Molecular Formula: C3H6F2O2
Molecular Weight: 112.08 g/mol
Recommended Use: Laboratory chemicals, research and development, chemical intermediates
Supplier Information: Name, address, emergency contact, phone number of supplier or manufacturer
GHS Classification: Acute toxicity (oral, dermal), Skin and eye irritation, Specific target organ toxicity
Signal Word: Warning
Hazard Statements: Harmful if swallowed; Causes skin irritation; Causes serious eye irritation
Precautionary Statements: Avoid breathing dust or vapors; Wash hands and face thoroughly; Wear protective gloves, eye protection; If on skin, wash with plenty of water; If in eyes, rinse cautiously for several minutes
Pictograms: Exclamation mark
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Irritation of eyes, skin, and respiratory tract, possible gastrointestinal upset if swallowed
Chemical Name: 2,2-Difluoro-1,3-propanediol
CAS Number: 359-98-4
Concentration: 98% or greater as supplied
Impurities/Additives: Possible traces of related organic compounds or residual solvents from synthesis – typically below 2% total
Inhalation: Move person to fresh air; assist breathing if necessary; seek medical attention for symptoms
Skin Contact: Remove contaminated clothing; rinse skin with water for at least 15 minutes; seek medical advice if irritation develops
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; seek prompt medical help
Ingestion: Rinse mouth; do not induce vomiting; call poison control or a physician immediately
Most Important Symptoms: Redness, pain, irritation, possible headache, nausea, dizziness
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, or water spray
Unsuitable Media: Direct water jets could spread fire
Specific Hazards: May produce toxic vapors including hydrogen fluoride, carbon oxides when burning
Protective Actions: Firefighters use self-contained breathing apparatus and full protective gear
Special Procedures: Cool fire-exposed containers with water spray to prevent rupture
Explosion Hazard: Not known to be explosive under normal conditions, but may react with strong oxidizers
Personal Precautions: Evacuate area; ensure adequate ventilation; wear proper protective equipment to prevent skin, eye contact, and inhalation
Environmental Precautions: Prevent further leakage or spillage if safe to do so; do not discharge to drains, surface water, or environment
Containment: Absorb spill with non-combustible absorbent material (sand, earth, vermiculite); collect for proper disposal
Cleanup Procedures: Use non-sparking tools, avoid dust or vapor formation, ventilate area thoroughly; ensure all residues are cleaned up and disposed of safely
Safe Handling: Avoid contact with skin, eyes, and clothing; handle in well-ventilated areas; prevent inhalation of vapor or dust
Storage Conditions: Store in tightly sealed original container, in a cool, dry, well-ventilated place away from incompatible substances such as oxidizers and bases
Storage Temperature: Keep away from direct sunlight, sources of ignition; recommended storage at room temperature
Materials to Avoid: Strong acids, strong bases, strong oxidizing agents
Occupational Exposure Limits: No specific national exposure limits established
Engineering Controls: Use chemical fume hood or adequate ventilation; maintain eyewash and safety shower stations nearby
Personal Protective Equipment: Chemical-resistant gloves (nitrile or similar), safety goggles or face shield, laboratory coat or chemical apron
Respiratory Protection: Use certified respirator if ventilation is inadequate or exposure limits are exceeded
General Hygiene: Wash hands after handling; avoid eating, drinking, or smoking in work area; remove contaminated clothing immediately
Appearance: Clear to slightly yellow liquid
Odor: Slight, sweet odor
Odor Threshold: Data not available
pH: Not determined
Melting Point/Freezing Point: Approximately -20°C
Boiling Point: Approximately 120 - 130°C at atmospheric pressure
Flash Point: Above 80°C (closed cup, estimated)
Evaporation Rate: Not determined
Flammability: Flammable liquid
Upper/Lower Flammability Limits: Not determined
Vapor Pressure: Low, estimated below 1 mmHg at 20°C
Vapor Density: Greater than air
Relative Density: Approximately 1.25 g/cm3
Solubility: Miscible with water and organic solvents
Partition Coefficient: Not determined
Auto-ignition Temperature: Not established
Decomposition Temperature: May decompose upon strong heating
Viscosity: Not determined
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: May react with strong oxidizing agents
Conditions to Avoid: Heat, flames, sparks, incompatible materials, moisture
Incompatible Materials: Strong acids, strong bases, strong oxidizers
Hazardous Decomposition Products: Hydrogen fluoride, carbon monoxide, carbon dioxide, toxic fumes
Polymerization: No dangerous polymerization expected under normal conditions
Likely Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Toxicity: Toxic if swallowed, moderate irritation through skin and eye contact
Chronic Effects: Repeated or prolonged skin contact can cause dermatitis; no established carcinogenicity; possible long-term organ effects based on analogous compounds
Symptoms: Irritation to eyes and skin, headache, nausea, dizziness, respiratory irritation if inhaled
LD50 (oral, rat): Estimated 300-700 mg/kg
Irritation/Corrosion: Eyes, skin, respiratory system
Systemic Effects: Possible central nervous system effects with significant overexposure
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA, or ACGIH
Other Data: No data on reproductive toxicity, germ cell mutagenicity, or teratogenicity; use caution due to lack of comprehensive studies
Ecotoxicity: Harmful to aquatic life; no specific data for fish, daphnia, or algae toxicity, but fluorinated organics can impact aquatic organisms
Persistence and Degradability: Not readily biodegradable; potential for moderate persistence in environment
Bioaccumulation: No data available, but generally low bioaccumulation for small fluorinated diols
Mobility in Soil: Expected to be mobile; soluble in water and likely to migrate in soil
Other Adverse Effects: Avoid release to the environment; possible impact if discharged in large quantities; fluorinated compounds can have long-term effects on ecosystem health
Waste Treatment Methods: Collect and send all waste, including absorbents, to approved chemical waste disposal facility
Disposal Containers: Use chemical-resistant, tightly sealed containers; follow local regulations
Disposal of Product: Do not dispose of through regular sewer or household waste; treat as hazardous
Contaminated Packaging: Decontaminate and recycle if possible, or dispose according to national and local regulations
Special Precautions for Disposal: Incinerate at licensed facility with flue gas cleaning where permitted; do not allow chemical to enter waterways
UN Number: UN 1993
Proper Shipping Name: Flammable liquid, n.o.s. (2,2-Difluoro-1,3-propanediol)
Transport Hazard Class(es): 3 (Flammable Liquids)
Packing Group: III
Environmental Hazards: Not marine pollutant by default, but local rules may vary
Special Precautions: Handle in accordance with good industrial hygiene and safety practices during transport; emergency procedures for spill or fire
Transport Labels: Flammable liquid
Occupational Safety and Health: Not specifically regulated by OSHA; observe general duty for safe workplace
TSCA Inventory: Listed or exempt
SARA Title III Section 313: Not listed
EPCRA – Emergency Planning and Community Right-to-Know Act: Not subject to reporting requirements
State Regulations: Consult state and local regulations; may be subject to additional reporting or handling obligations in some regions
Canada DSL/NDSL: Check current status prior to import or sale
Other Global Inventories: Review chemical-specific requirements in countries where handled or transported
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