Product Name: (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol
Synonyms: D-threo-2-Amino-1-phenyl-1,3-propanediol, Threo-2-Amino-1-phenyl-1,3-propanediol
CAS Number: 10422-97-4
Molecular Formula: C9H13NO2
Molecular Weight: 167.21 g/mol
Manufacturer: [Company/Contact Information]
Recommended Use: Chemical synthesis, research, pharmaceutical intermediate
Restrictions on Use: Not intended for food, drug, or household use; laboratory use only
GHS Classification: Acute toxicity (Oral, Dermal, Inhalation) Category 4; Eye Irritation Category 2A
Signal Word: Warning
Hazard Statements: Harmful if swallowed, in contact with skin, or if inhaled; causes serious eye irritation; may cause respiratory irritation
Pictograms: Exclamation mark (Irritant)
Precautionary Statements: Avoid breathing dust or vapors; wash thoroughly after handling; wear protective gloves, clothing, and eye protection; if exposed or concerned, seek medical advice
Route of Exposure: Inhalation, ingestion, skin, and eye contact
Potential Health Effects: Irritation of eyes, skin, respiratory tract; possible harm if absorbed or swallowed; symptoms might include dizziness, headache, nausea, and local irritation
NFPA Ratings: Health: 2; Flammability: 1; Reactivity: 0
Chemical Name: (1S,2S)-(+)-2-Amino-1-phenyl-1,3-propanediol
CAS Number: 10422-97-4
Percent: >98% purity
Impurities: Trace organic solvents, residual moisture (low concentration, <2%)
Stabilizing Additives: None reported in purified laboratory-grade batches
Inhalation: Remove to fresh air; keep patient comfortable and warm; consult medical professional for symptoms such as coughing, trouble breathing, or disorientation
Skin Contact: Remove contaminated clothing quickly; wash skin thoroughly with plenty of water and mild soap; seek medical attention for irritation, burns, or prolonged symptoms
Eye Contact: Rinse cautiously with clean, lukewarm water for at least 15 minutes, holding eyelids open; remove contact lenses if present and easy to do so; pursue medical advice if discomfort persists
Ingestion: Rinse mouth, never induce vomiting unless instructed by medical personnel; do not give anything by mouth to an unconscious person; seek immediate medical attention if larger amounts swallowed or symptoms develop
General Notes: Always provide this safety data sheet to medical staff; monitor vital signs and basic support while awaiting help
Suitable Extinguishing Media: Water spray, carbon dioxide (CO2), dry chemical powder, foam
Unsuitable Extinguishing Media: Strong water jet; may spread contamination
Special Hazards Arising: May produce irritating or toxic fumes (nitrogen oxides, carbon monoxide, carbon dioxide) on combustion; risk to firefighters from inhaling combustion products
Protective Equipment for Firefighters: Full protective gear including self-contained breathing apparatus (SCBA); chemical protective clothing and gloves
Precautions: Move containers away from fire area if safely possible; avoid runoff contaminated water; keep unprotected persons away from the area
Personal Protection: Wear appropriate lab coat, chemical-resistant gloves, safety goggles, and, where dust or aerosol may be generated, a respirator
Emergency Procedures: Evacuate unprotected personnel from the spill area; ventilate the area adequately
Containment Methods: Avoid dust formation; prevent further leakage or spillage if safe to do so; block drains to prevent environmental entry
Cleanup Methods: Collect solid material mechanically using non-sparking tools; for spills, absorb with inert material such as sand or vermiculite and transfer to a chemical waste container; wash spill area with water and detergent; collect washings for disposal
Environmental Precautions: Prevent further spillage and entry into waterways or soil; contact local environmental authorities if significant release occurs
Handling: Always handle in well-ventilated laboratory settings or fume hoods; minimize dust and aerosol generation; avoid all forms of ingestion, inhalation, and skin contact; never use mouth for pipetting; keep containers tightly closed when not in use; practice good hygiene, such as washing hands after handling
Storage Conditions: Store in a tightly sealed, clearly labeled container away from incompatible materials; preferred temperature 2-8°C, protected from light, excessive moisture, and physical damage
Incompatible Materials: Strong acids, strong bases, oxidizing agents; risk of violent reaction with these chemicals
Storage Area Requirements: Dry, cool, and properly ventilated area; secure to prevent unauthorized access
Occupational Exposure Limits: No established national limits for this substance; use workplace controls as for compounds of similar toxicity
Engineering Controls: Use fume hoods, local exhaust, and mechanical ventilation to keep airborne levels below nuisance thresholds
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), lab coat, safety glasses with side shields or chemical splash goggles; for dusty work, use NIOSH/MSHA approved dust respirator
Hygiene Measures: Do not eat, drink, or smoke while working with this material; wash hands, face, and any exposed skin thoroughly after handling
Exposure Monitoring: Implement regular air monitoring in working environment, especially during procedures involving powder or aerosol
Appearance: White to off-white crystalline solid
Odor: Odorless or faint organic smell
Odor Threshold: Not established
pH: 8-9 in 1% aqueous solution
Melting Point/Range: 110-115°C
Boiling Point/Range: Decomposes before boiling
Flash Point: Not available
Flammability (solid, gas): Not highly flammable under normal conditions
Explosion Limits: Not available
Vapor Pressure: Negligible at room temperature
Vapor Density: Not determined
Relative Density (Water=1): Approximately 1.20
Solubility: Soluble in water, ethanol, and some other polar organic solvents
Partition Coefficient n-octanol/water (log Kow): Not determined
Auto-ignition Temperature: Not determined
Decomposition Temperature: Above 200°C
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended storage conditions; avoids excess humidity, open flames, and temperatures above 40°C
Reactivity: Low at ambient temperatures; avoid exposure to strong acids, bases, oxidizing agents; incompatible with strong dehydrating agents
Hazardous Reactions: No polymerization or self-reactivity expected under normal handling; exothermic decomposition possible on strong heating
Conditions to Avoid: Extreme heat, strong oxidizers, moisture, light
Hazardous Decomposition Products: Decomposes to carbon monoxide, carbon dioxide, nitrogen oxides under fire or severe heating; toxic fumes possible in case of fire
Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity (estimated): LD50 (oral, rat): >300 mg/kg (precise values sparse); LD50 (skin, rabbit): not available
Skin Corrosion/Irritation: Can cause mild to moderate irritation with prolonged exposure
Eye Damage/Irritation: Causes moderate to severe eye irritation—burning, redness, tearing can result
Respiratory Effects: Inhalation of dust may irritate upper respiratory tract; might provoke coughing, sneezing, chest tightness
Sensitization: Not classified as sensitizer based on available information; potential for dermatological reaction cannot be excluded on repeated exposure
Chronic Toxicity: No conclusive data; prolonged exposure could affect liver, kidneys, or nervous system based on structural analogy with related compounds
Carcinogenicity/Mutagenicity: Not listed by IARC, NTP, OSHA
Reproductive Toxicity: Data is not sufficient to make a determination
Medical Symptoms: Headache, dizziness, skin or eye redness, nausea
Aquatic Toxicity: May be harmful to aquatic life; insufficient data for chronic effects; do not discharge to waterways or soil
Soil Mobility: Readily soluble in water increases mobility; possible leaching if released
Bioaccumulation Potential: Likely low, molecular structure indicates limited persistence in the environment
Degradation: Not readily biodegradable according to standard tests; breakdown in environment may be slow
Other Ecological Effects: No data on ozone depletion or endocrine disruption; best practice dictates avoidance of environmental release
Waste Disposal Methods: Dispose of in accordance with local, state, and federal regulations; incineration preferred for organic chemical waste; avoid direct landfill or drain disposal
Contaminated Packaging: Rinse empty containers thoroughly, then discard as hazardous waste; do not reuse packaging
Additional Notes: Consult licensed waste disposal contractor; retain documentation of all disposals and cleanup activities as required by regulation
UN Number: Not regulated
Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Classes: Not applicable
Packing Group: Not applicable
Special Precautions: Protect packages from mechanical damage and moisture; ensure containers are sealed and clearly labeled; carry documentation and emergency contact numbers during shipment
Environmental Hazards: Avoid accidental release during transport; ensure secure containment in transit vehicles
OSHA Status: Not listed as a hazardous chemical under OSHA Hazard Communication Standard
TSCA: Listed on the United States Toxic Substances Control Act inventory
EU REACH: Not registered or evaluated
Canadian DSL/NDSL: Not listed
SARA Title III Section 313: Not subject to reporting
California Proposition 65: Not listed as a known carcinogen or reproductive toxin
WHMIS (Canada): Not classified as a hazardous product
Other Regulations: Check local and national guidelines for updates on classification, transport, and disposal requirements; maintain SDS records for regulatory audits and inspections
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