Material Safety Data Sheet: (1R,2S)-(-)-2-Amino-1-phenyl-1,3-propanediol

Identification

Product Name: (1R,2S)-(-)-2-Amino-1-phenyl-1,3-propanediol
Synonyms: (-)-Norpseudoephedrine, Cathine
Chemical Formula: C9H13NO2
Molecular Weight: 167.21 g/mol
CAS Number: 3736-08-1
Recommended Use: Research, chemical synthesis, reference standards
Supplier: Provided by registered chemical distributors for laboratory use
Contact Information: Available from product distributor or manufacturer upon request
Emergency Phone: Refer to local Poison Control Center or local emergency numbers

Hazard Identification

Classification: Classified as harmful if swallowed, skin irritant, eye irritant, possible nervous system effect
Hazard Statements: May cause skin and eye irritation, harmful if inhaled or ingested, may affect central nervous system
Pictograms: Exclamation mark (GHS07)
Signal Word: Warning
Precautionary Statements: Avoid breathing dust or vapors, use protective gloves and eyewear, wash thoroughly after handling, do not eat, drink, or smoke while using
Potential Health Effects: May induce drowsiness, headache, nausea, or mild cardiovascular stimulation
Other Hazards: Not classified as flammable but may emit hazardous fumes during fire conditions

Composition / Information on Ingredients

Chemical Identity: (1R,2S)-(-)-2-Amino-1-phenyl-1,3-propanediol
CAS Number: 3736-08-1
Concentration: Greater than 98% purity
Impurities: Trace level synthesis byproducts may be present at less than 2%
Formulation: Supplied as a solid, crystal, or powder

First Aid Measures

Inhalation: Move affected individual to fresh air, monitor for breathing difficulty, provide oxygen if needed, seek medical advice
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water and mild soap, get medical attention if irritation persists
Eye Contact: Rinse with plenty of clean water for at least 15 minutes, lift eyelids occasionally, obtain medical help if symptoms do not subside
Ingestion: Rinse mouth with water immediately, do not induce vomiting, never give liquids to unconscious individuals, get medical care as soon as possible
Most Important Symptoms: May include headache, drowsiness, nausea, dizziness, skin or eye irritation

Fire-Fighting Measures

Suitable Extinguishing Media: Use dry chemical, CO2, foam, or water spray as appropriate for area
Unsuitable Extinguishing Media: Avoid high-pressure water streams, which could spread the chemical
Specific Hazards: Combustion may yield irritating fumes, toxic oxides of nitrogen, carbon monoxide, carbon dioxide
Protective Equipment for Firefighters: Wear positive pressure self-contained breathing apparatus and full protective gear
Precautions: Move containers from fire area if safe, keep non-emergency personnel away, cool containers exposed to heat with water spray

Accidental Release Measures

Personal Precautions: Wear gloves, safety goggles, protective clothing, use a dust mask or respirator in dust-producing situations
Environmental Precautions: Prevent entry into drains, sewers, surface waters, and soil
Methods for Containment and Cleanup: Scoop up spilled material, avoid creating dust, place waste in closed container for disposal, ventilate area, wash residue away with soap and water
Decontamination: Use damp cloths or absorbent materials for final clean-up

Handling and Storage

Safe Handling: Work only in well-ventilated areas or chemical fume hoods, keep away from food and drink, practice good hygiene, wear recommended PPE
Conditions for Storage: Store in tightly sealed original containers, keep in a cool, dry, well-ventilated place, avoid direct sunlight and sources of heat or ignition
Incompatibilities: Strong oxidizing agents, strong acids
Handling Precautions: Prevent dust generation, handle with care to avoid spills, wash hands after use

Exposure Controls / Personal Protection

Exposure Limits: No established occupational exposure limits for this compound
Engineering Controls: Use local exhaust ventilation, eye wash stations, and safety showers
Personal Protection: Chemical-resistant gloves (nitrile or neoprene), lab coat, safety goggles, dust/particulate respirator if risk of dust generation
Environmental Exposure Controls: Prevent uncontrolled release to environment, handle waste as hazardous

Physical and Chemical Properties

Appearance: White to off-white crystalline solid
Odor: Odorless or faint, non-distinctive
pH: Not applicable (solid form)
Melting Point: 187-190°C (369-374°F)
Boiling Point: Data not available
Solubility: Soluble in water and alcohols
Flash Point: Not determined
Vapor Pressure: Not applicable at room temperature
Density: Approximately 1.2 g/cm³
Partition Coefficient (Log Kow): Estimated 0.2-0.8
Stability: Stable under normal handling and storage conditions
Other Properties: No explosive or oxidizing properties observed

Stability and Reactivity

Stability: Stable under standard conditions, avoid exposure to moisture and high temperatures
Reactivity: Reacts with strong acids, strong oxidizers
Possibility of Hazardous Reactions: May form hazardous decomposition products under fire or improper storage
Decomposition Products: Nitrogen oxides, carbon oxides, potentially irritating organic vapors
Conditions to Avoid: Excessive heat, ignition sources, incompatible substances, prolonged exposure to air or light

Toxicological Information

Likely Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Effects: May cause irritation to skin, eyes, mucous membranes; dizziness, headache, fatigue possible if inhaled or ingested
Chronic Effects: Prolonged exposure may affect central nervous system; sensitization or allergic reactions have not been observed in most individuals
Toxicity Data: No comprehensive animal toxicity data available, structurally related compounds have shown oral LD50 in rodents above 500 mg/kg
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, ACGIH, or OSHA
Mutagenicity: No mutagenic effects reported in available literature
Reproductive Toxicity: No data available on teratogenic or reproductive effects

Ecological Information

Ecotoxicity: Information specific to this compound is limited, related substances may show low aquatic toxicity
Persistence and Degradability: Expected to be biodegradable over time under environmental conditions
Bioaccumulation Potential: Low potential based on Log Kow
Mobility in Soil: Should be mobile in aqueous environments, may leach through soil if released
Other Adverse Effects: Do not release undiluted or large quantities into water streams

Disposal Considerations

Waste Disposal Methods: Collect as hazardous chemical waste, send for disposal at licensed chemical waste facility
Contaminated Packaging: Dispose of as chemical waste following local regulations, do not reuse packaging
RCRA Status: Not listed specifically, but manage as hazardous waste as a precaution
Special Considerations: Prevent release into sewers, surface, or ground waters, consult waste management professionals if unsure

Transport Information

UN Number: Not assigned
Proper Shipping Name: Not regulated for transport in small quantities
Transport Hazard Class: None assigned
Packing Group: Not regulated
Environmental Hazards: Not classified as environmentally hazardous by transport regulations
Special Precautions for Transport: Protect containers from damage or breakage, avoid transporting with incompatible materials

Regulatory Information

Inventory Listings: Check local chemical inventories (e.g., TSCA, EINECS, ENCS, DSL) for region-specific regulatory status
Labeling Requirements: GHS-compliant labeling, hazard statements, and precautionary advice required
Workplace Regulations: Subject to occupational safety regulations for laboratory chemicals
SARA Title III: Not specifically listed under Sections 302, 313
California Proposition 65: Not listed
Other National or Regional Regulations: Compliance with country-specific chemical control statutes as required