Product Name: (1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol
Synonyms: L-Ephedrine glycol, (R,R)-2-Amino-1-phenyl-1,3-propanediol
Chemical Formula: C9H13NO2
CAS Number: 56515-32-9
Manufacturer: Chemical Supply Division, contact information available upon request
Uses: Intermediate for pharmaceutical and chemical synthesis
Emergency Phone: Provided by supplier
Classification: Eye irritation category 2A, Skin irritation category 2, Specific target organ toxicity-single exposure category 3
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, causes skin irritation, may cause respiratory irritation
Precautionary Statements: Wear protective gloves/eye protection; avoid breathing dust; wash thoroughly after handling; use only in well-ventilated areas
Pictograms: Exclamation mark
Routes of Exposure: Inhalation, dermal, ingestion, ocular
Chemical Name: (1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol
CAS Number: 56515-32-9
Concentration: 98% or greater
Impurities: Trace amounts of structurally similar compounds, unreacted starting materials, water content below 1%
Additives: None reported
Eye Contact: Rinse thoroughly with plenty of water for at least 15 minutes, occasionally lifting eyelids, seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing, wash skin with plenty of water and soap for several minutes, consult a physician for persistent symptoms
Inhalation: Move person to fresh air, maintain open airway, administer oxygen if breathing becomes difficult, seek immediate medical attention if symptoms develop
Ingestion: Rinse mouth, do not induce vomiting unless instructed, seek immediate medical assistance, never administer anything by mouth to an unconscious person
Notes for Medical Staff: Treat symptomatically, monitor for allergic reactions or respiratory distress
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Unsuitable Media: Strong, direct water stream may scatter material
Thermal Hazards: Product decomposes at high temperatures producing toxic fumes such as nitrogen oxides, carbon monoxide, carbon dioxide
Firefighters’ Protection: Wear self-contained breathing apparatus, full protective gear; avoid inhalation of combustion products
Fire Behavior: Solid form may burn when exposed to high heat; dust may form explosive mixtures with air
Special Procedures: Move material from fire area if possible, prevent fire water runoff from entering surface or groundwater
Personal Precautions: Wear protective equipment including gloves, safety glasses, respiratory protection
Environmental Precautions: Prevent entry into drains, sewers, surface waters, and soil
Spill Clean-up: Sweep up and shovel material using methods to prevent dust generation; place material in a suitable, sealed chemical waste container
Disposal: Dispose in accordance with local regulations
Decontamination: Wash area with soap and water after removal of bulk material, ventilate the area
Handling: Avoid breathing dust and contact with skin or eyes, handle in a well-ventilated area, use local exhaust or fume hood, maintain good hygiene practices
Storage Conditions: Store in original, tightly closed container in a cool, dry, well-ventilated, and secure place away from incompatible substances such as strong oxidizers, acids, and bases
Incompatibilities: Strong acids and oxidizing agents
Other Precautions: Keep away from direct sunlight, moisture, sources of ignition or heat
Engineering Controls: Work in a fume hood or with adequate local exhaust, ensure adequate ventilation to keep airborne levels below recommended exposure limits
Exposure Limits: No occupational exposure limits established in available literature, control as for nuisance dust
Personal Protection: Nitrile or latex gloves, chemical splash goggles or face shield, lab coat or apron, dust mask (P2/P3 filter) if airborne particles are generated, use respiratory protection if engineering controls do not maintain exposure below recommended limits
Environmental Protection: Prevent chemical waste and contaminated water from entering soil, sewers, or water bodies
Appearance: White to off-white crystalline powder
Odor: Faint, characteristic amine odor
Odor Threshold: Not established
pH: 7-8 (1% aqueous solution)
Melting Point: 98-102°C
Boiling Point: Decomposes before boiling
Flash Point: Above 180°C (closed cup)
Evaporation Rate: Not applicable (solid)
Flammability: May be combustible at high temperature
Vapor Pressure: Negligible at room temperature
Vapor Density: Not applicable (solid)
Relative Density: 1.15-1.20 g/cm³
Solubility: Soluble in water, ethanol, partially soluble in methanol, insoluble in non-polar solvents
Partition Coefficient (log Kow): Estimated 0.1-0.5
Autoignition Temperature: Not readily available
Decomposition Temperature: Above 175°C
Viscosity: Not applicable (solid)
Molecular Weight: 167.21 g/mol
Chemical Stability: Stable under normal ambient and anticipated storage and handling conditions
Reactivity: No dangerous reactions known under normal conditions; reacts with strong acids, oxidizing agents causing heat and possible emission of gases
Conditions to Avoid: Exposure to incompatible substances, excessive heat, open flame, high humidity
Hazardous Decomposition Products: Thermal decomposition may yield nitrogen oxides, carbon monoxide, carbon dioxide, unknown organic fragments
Polymerization: No hazardous polymerization anticipated
Sensitive Materials: Strong acids, bases, oxidizing agents
Acute Toxicity: Data lacking for specific oral, dermal, inhalation LD50 for this isomer; structurally related compounds reported LD50 in rats: >500 mg/kg
Skin Corrosion/Irritation: May cause moderate to severe skin irritation with prolonged or repeated contact
Eye Damage/Irritation: Strong risk of eye irritation and redness upon exposure
Respiratory Sensitization: Inhalation of dust can trigger cough, sore throat, possible temporary respiratory discomfort
Skin Sensitization: Potential for allergic skin reaction cannot be excluded
Chronic Effects: No data for chronic toxicity, sensitization, carcinogenicity; structurally related chemicals show low chronic toxicity at anticipated exposure levels
Other Relevant Data: Not considered mutagenic or carcinogenic based on analogy to parent structure; avoid uncontrolled exposure
Ecotoxicity: No experimental data, estimated low acute hazard to aquatic organisms, structurally similar compounds moderately biodegradable
Persistence and Degradability: Expected to undergo microbial degradation in soil and water
Bioaccumulative Potential: Low based on physicochemical properties and estimated log Kow
Mobility in Soil: Moderate, soluble in water, could leach through soil with rainwater
Other Adverse Effects: Large spills in aquatic environments may cause oxygen depletion; precaution to prevent discharge recommended
Waste Treatment Methods: Chemical incineration in compliance with official regulations; collect and transfer liquid and solid waste to a licensed disposal contractor
Unused Product Disposal: Do not release to environment or enter drains; store residue in sealed, labeled containers
Contaminated Packaging: Treat as hazardous, rinse thoroughly and dispose in accordance with local regulations
Local Disposal Laws: Follow all federal, state, and local environmental regulations for chemical waste
UN Number: Not assigned
UN Proper Shipping Name: Not regulated by international transport guidelines (IMDG, IATA, DOT) in standard package sizes
Transport Hazard Class: Not classified as dangerous for transport
Packing Group: Not applicable
Special Precautions: Protect containers from physical damage, moisture, and heat during transit, document and declare substance appropriately
Environmental Hazards: Not a marine pollutant based on available data
TSCA (United States): Listed, not subject to specific restrictions
REACH (Europe): Pre-registered, not classified for special restrictions under current guidelines
OSHA (US): Not classified as a hazardous substance under OSHA Hazard Communication Standard 29 CFR 1910.1200
SARA (US): Not identified on lists of hazardous air pollutants or extremely hazardous substances
DSL (Canada): Not listed on the Canadian Domestic Substances List
WHMIS Classification: Not classified
Other International Inventories: Review country-specific chemical inventories prior to import or handling
Labeling Requirements: Comply with relevant workplace hazard communication and chemical labeling standards
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