Back in the mid-20th century, chemists started to notice the usefulness of chiral diamines in drug development and industrial catalysis. (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate emerged as a stronger contender than its earlier cousins for one key reason: its robust ability to create asymmetric environments in reactions. Early research published in the 1970s brought this compound into focus as a resolving agent, particularly for producing important enantiomerically pure pharmaceuticals. Over the decades, the demand for chiral building blocks in the fine chemicals sector kept pushing for more refined production and smarter applications. It’s hard to overstate the impact of reliable, scalable chiral diamine synthesis—without it, whole branches of specialty chemistry and pharmaceutical production would backslide to older, sloppier methods.
(1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate stands out as a salt combining a chiral cyclohexanediamine with L-tartaric acid. This union packs a punch for chemists who need a stable, easy-to-handle solid. Its main role traces to building blocks for active pharmaceutical ingredients and chiral ligands in catalysis. When I worked in a chemical synthesis lab, handling this material, its performance always came through reliably—it offered predictable melting points and solution behaviors, which is a relief for scaling up reactions in unpredictable factory conditions.
Anyone who’s spent time in a lab gets why melting point and solubility matter. (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate looks like a white crystalline powder, typically melting in the 165–170 °C range. The salt dissolves readily in water but much less in organic solvents, helping to separate it from unwanted byproducts. Its structure features two amine groups bonded to a rigid cyclohexane ring, and the tartrate counterion means good thermal stability for most benchwork.
Shoppers for specialty chemicals zero in on certain details: purity above 98%, specific rotation values (typically around +47° in water), and identification using CAS number 4265-58-1. Labels show hazard pictograms, signal words, and storage recommendations, never a waste of space when chemicals can cause skin irritation or more serious harm. Reliable vendors always verify origin and batch traceability, crucial for work under regulatory oversight.
Traditional prep starts with the resolution of racemic 1,2-cyclohexanediamine using L-tartaric acid in water. Stirring up the mixture precipitates the desired enantiomer’s tartrate salt. After filtering, washing, and drying, you end up with pretty pure (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate. For anyone running scale-up in the plant, small tweaks—solvent volumes, stirring rates—boost yield and knock down impurity levels. Labs favor this reliable method since the raw materials come easily, and reaction conditions favor reproducibility.
As a versatile diamine, this molecule partners up with a range of reagents to form Schiff bases, amides, ureas, and metal complexes. In asymmetric catalysis, it transforms into chiral ligands for well-known reactions like hydrogenation, useful for knocking out one enantiomer over another when making drug ingredients. It also converts into protected derivatives for multi-step organic synthesis. In my team’s hands, it smooths out reaction selectivity and often cuts down on those annoying side products that eat up time in purification.
On procurement lists or in scientific papers, you’ll find several aliases for this compound: (1R,2R)-Diaminocyclohexane L-tartrate, (R,R)-DCHD L-tartrate, and (R,R)-1,2-Cyclohexanediamine tartrate pop up most often. Proper naming helps with ordering, compliance, and avoiding dangerous mix-ups, which anyone in a regulated lab will appreciate.
Anyone handling amine salts should know to respect personal protection: gloves, goggles, lab coat, and fume hood for certain prep steps. Safety data sheets warn about the risks of eye and skin irritation. Good labs keep emergency showers and eyewash stations close by, and knowledgeable chemists avoid inhaling dust by working in properly ventilated areas. In terms of transport, classified as a low-hazard commodity, this compound still requires careful packaging to avoid leaks or spills during shipping. Traceability in storage—using labeled containers and monitored logs—helps with compliance and, more importantly, keeps hazards to a minimum.
Pharmaceutical companies prize this compound for both chiral pool synthesis and as a resolving agent for racemic drugs. Its value keeps rising as demand for single-enantiomer drugs explodes. It also proves its worth in making chiral catalysts for asymmetric hydrogenation, an indispensable step for prepping certain drug molecules and agrochemicals. Chemical research teams at universities and contract research organizations keep it on hand for a range of custom syntheses and exploratory work. Its flexibility makes it a steady workhorse in both basic and applied chemistry labs.
In the last decade, a lot of R&D money has moved toward greener, more sustainable ways to prepare this molecule. Efforts target higher yields and less solvent waste, sometimes by leveraging biocatalysis or continuous manufacturing. Academic groups and partner companies churn out new ligands based on the diamine core, trying for tighter selectivity in big-money pharma projects. Intellectual property filings show steady patent activity—and it’s not slowing down—so innovation continues to ride this steady platform. In my experience, the presence of a robust supply chain means startups and established players both get what they need fast, so innovation cycles don’t get bogged down waiting for starting material.
Toxicologists have dug into both acute and chronic effects of (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate. Testing on rats and rabbits indicates low oral toxicity but flag some risk of skin and eye irritation with direct, concentrated exposure. As with many amines, proper ventilation curtails risk of respiratory irritation. Long-term use in the industry and research settings has yet to surface any major toxicity patterns, but regulations push for regular monitoring and updated hazard assessments. I remember the first time our safety team gave an update—they focused on keeping minute exposures in check rather than rare, catastrophic incidents, which seems to fit with the safety record so far.
Looking down the road, demand for this diamine will likely pick up speed in pharmaceutical and specialty chemical markets. Growth in enantioselective drug manufacturing creates long-term opportunities. Advances in continuous flow production and renewable sourcing of starting materials could chip away at costs and environmental impact. As regulations keep tightening—especially in Europe and North America—producers will face growing pressure to provide cleaner, safer, and fully documented products. If R&D finds even more efficient catalytic applications or bio-inspired routes to this salt, industry will pivot quickly to lock in performance gains. All evidence suggests that (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate remains a reliable touchstone for anyone aiming to blend classic chemical synthesis with modern manufacturing needs.
(1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate gets a lot of attention in organic chemistry labs for good reason. Chemists look to it as a chiral ligand, a backbone for building more complex structures that need precise shapes. Its structure gives it that all-important chirality, or handedness, which often means the difference between a breakthrough drug and just another failed batch. Every medicinal chemist chasing a new molecule pays extra attention to how left- or right-handed a compound is, and this diamine gives them an excellent starting point.
Asymmetric catalysis stands front and center in most modern pharmaceutical projects. Getting both high yield and selectivity from a catalytic reaction—where only one mirror-image product is desired—can make or break a project. This is where (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate shines. Whether it's a chemist at a research university or a team at a pharma company, the ability to generate only one enantiomer means safer and more effective drugs. For example, certain anti-cancer treatments draw a clear boundary between helpful and harmful forms of molecules; a single wrong turn at the atomic level can erase the benefits or even add dangerous side effects. That's not theoretical—thalidomide's history proves exactly why scientists put such a premium on enantiopure compounds.
The impact ripples way beyond the confines of chemistry journals. More than half of the drugs approved by regulatory agencies since 2010 are chiral—meaning their safety and function depend directly on their three-dimensional form. Using chiral diamines like this tartrate lets developers avoid months of troubleshooting. Instead, they bring new products to market faster and with greater confidence.
This approach also supports environmental goals. Chemical synthesis built on efficiency creates fewer byproducts, translating into less hazardous waste and lower costs for disposal. The pressure mounts each year for both regulatory compliance and genuine corporate sustainability; every process that reduces chemical footprints gives companies a clear advantage.
Introducing any specialty chemical in high-volume production comes with a set of headaches. Reliable sourcing, purity, and cost all factor into decision-making on the ground. Long before a new active pharmaceutical ingredient ever sees clinical trials, manufacturers weigh the cost-effectiveness and reliability of their chiral building blocks. Opportunity opens up for suppliers who can ensure high-purity (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate with minimal batch variation.
One area for improvement involves streamlining synthesis and purification. Scale-up from gram quantities in the lab to kilograms in production plants can reveal weaknesses. Greater collaboration between academic researchers and industrial partners promises real gains here. Bringing green chemistry principles into daily practice helps reduce environmental impacts and sharpens competitive edges.
As chemistry drives progress in medicine, materials science, and green manufacturing, the small choices—like picking the right chiral diamine—echo outwards into real changes for patients and the environment. Harnessing the full potential of (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate keeps the science grounded while delivering tangible benefits beyond the laboratory.
"What's the purity specification for this product?" That question isn’t just another checkbox on a technical sheet. People in labs, warehouses, and on factory floors rely on those numbers every single day. I remember how, in my own work helping small manufacturers source ingredients, purity claims made or broke deals. Ask any formulator or quality control manager, and they’ll tell you—purity isn’t some fancy number to print on a label. It shapes product performance, safety, and reputation.
Not all purity specifications hold the same weight. Some suppliers shoot for "99%" purity without saying much about the rest. A missing detail or two means those last 1% impurities could hold anything, sometimes including substances that clash with regulations or harm users. There’s a world of difference between the numbers on a spec sheet and the real data behind them.
I've watched teams scramble when mystery contaminants showed up in what should have been a routine powdered chemical. That shipment went straight back. Brands using these ingredients face big risks, from recalled product batches to legal fallout. Back in the day, the news about contaminated supplements or pharmaceuticals ruining trust taught everyone that skipping the details on purity costs real money and credibility.
It’s not just about trust; clear purity specs keep people safe. Official purity requirements come from groups like the US Pharmacopeia or the European Pharmacopoeia, or from government mandates. In food, medicine, cosmetics, and chemicals, these rules grab hold for a reason. Ask anyone who has handled an adulteration scandal—clear, science-based specs could prevent whole recalls.
A good purity report does more than state a percentage. It spells out the detection method, lists known contaminants, and sets limits. For example, if you’re producing vitamin C, the paperwork should say how much ascorbic acid, how much water, what trace solvents might lurk, and at what levels they’re acceptable. The methods need to check out with the latest lab practices, like HPLC or mass spectrometry.
People selling to regulated industries, like pharmaceuticals or food, don’t get a free pass. FDA and international standards demand robust documentation. Buying or selling without proper specs isn’t worth it—you could be facing dumped products, regulatory heat, or worse, harm to consumers.
Teams that take these specs seriously stand out. I’ve seen small businesses move ahead in tough markets because they demanded more detail from their suppliers, checked lab data, and ran in-house spot tests. Every time they send a purchase order, someone asks about certificates of analysis, traceability, and testing protocols. Those questions keep everyone honest.
But the process works both ways. Manufacturers gain loyalty from customers if they don’t just toss out “99% pure” numbers, but show real analytics and independent third-party results. That approach breeds real transparency. Which, these days, does a lot to lift a brand above the countless others online.
Purity numbers shouldn’t just satisfy paperwork. Genuine improvements show up in more detailed testing, third-party audits, and stubbornness about knowing exactly what’s in a shipment. Some companies set up open lines between buyers and technical teams, so customers never have to guess what each spec means.
By pushing for stricter, better communicated purity standards, companies don’t just cover themselves. They build a system people can trust, with less risk of costly mistakes, less stress for staff, and higher quality for everyone who eventually uses the product—whether it goes into a snack bar, a medication, or an electronic component.
Anyone who’s worked with chemicals in the lab knows the mess that can happen from poor storage. No one likes seeing a valuable reagent ruined just because it picked up water from the air or picked up grime from a dusty shelf. (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate may not grab headlines like a new drug or a wild patent, but every clean reaction in research or industry owes at least a nod to the person who stored the chemicals right.
This compound takes lessons from any sensitive organic salt: it stays happiest in a dry place. Humidity can sneak into containers and lead to clumping, slow changes, or a mess that takes twice as long to clean up. Always use tightly sealed bottles or jars, ideally glass with solid caps or heavy plastic. The advice may sound simple, but even top labs have seen crystals fudge up after a careless seal left air gaps overnight.
If you work in a climate with humid summers—think the American South or coastal Asia—throw in a small bag of desiccant. Silica gel can help. Swapping it out a couple times a year makes sense, because moisture creeps in every time a bottle opens.
Room temperature works for (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate. Most reference books put the comfort zone between 15°C and 25°C. Super-hot storage rooms or windowsills are trouble, since heat speeds up unwanted changes. Refrigerators help stretch shelf life in places where summer heat hits harder.
Don’t toss this compound into deep freezers unless stability data says it’s safe. Some salts pull in water and cake when they return to room temperature—then scooping out a dry powder becomes a nightmare.
Dust, oils from skin, and leftover powder from other chemicals sneak in if people get lazy in the lab. Pour powders with clean spatulas, or shake out needed amounts onto clean paper instead of digging hands into bottles. Label containers with open dates and always use the “first-in, first-out” rule to prevent forgotten batches from turning useless.
If you have leftover material you’re not using soon, split your stock into smaller bottles. That way, exposure from repeated opening drops each time, and the back stock stays fresh. Not everyone budgets for this, but every research group benefits from tighter organization.
Light rarely does major harm to these organic salts, but plain prudence says keep chemicals away from direct sunlight or high heat lamps. Brown glass bottles block UV rays and add another layer of defense.
Training new staff takes real investment. Show newcomers real examples. No one forgets seeing a ruined batch fused to a sticky lid. Explaining the small details—what happens if powder cakes, how moisture creeps—means better habits and fewer rewrites of research.
Label bottles with clear names and hazards. Keep acids and bases—including this diamine tartrate—separate from strong oxidizers or reactive solvents. Most accidents come from simple mistakes, like grabbing the wrong bottle from a cluttered shelf.
Invest in sturdy shelving. Never stack heavy containers high or balance bottles on narrow ledges. The cost of a broken jar—wasted material, lost time, maybe injury—far outweighs the price of a few extra shelves.
Good chemical storage gives reliable experimental results, keeps budgets in check, and keeps dangerous mishaps to a minimum. Ask any experienced chemist—the real payoffs always show up in safe, steady work.
Stepping into a research lab or a pharmaceutical facility throws you straight into a world where the slightest compromise can have enormous consequences. There isn’t much room for guesswork. I’ve seen projects grind to a halt because a supplier provided a product that wasn’t up to scratch. No matter how sharp your team or advanced your equipment, one unreliable ingredient can disrupt everything down the line.
Researchers and manufacturers need clear answers from their suppliers. Anyone involved with pharmaceuticals or even basic lab research knows regulators and auditors demand traceability, documentation, and consistency at every step. If a product lacks a certificate of analysis or the source labs can’t trace it batch-by-batch, I wouldn’t touch it for regulated work.
Life isn’t as simple as ticking off a list of chemical properties. Agencies like the FDA, EMA, and others have learned the hard way that small oversights turn into big problems. They don’t just want you to say your product is pure — they want records showing how it’s made, stored, shipped, and tested. It’s about minimizing risk, not shifting blame.
Over the years, shortcuts tempt even the best teams, especially when a cheaper product from an unknown source appears. I’ve seen colleagues pay for that mistake later, with projects stalled or even recalled. Saving a few bucks upfront can lead to months of lost work. Documented, compliant products with known origins may cost more, but they keep that risk in check.
Certifications matter for a reason. If a supplier can’t provide paperwork showing compliance with Good Manufacturing Practice (GMP) or even Good Laboratory Practice (GLP) for research chemicals when appropriate, that’s a big red flag. I always check for ISO standards, too, which tells me the company takes their processes as seriously as those using the end product.
You also need to ask tough questions about testing. Is the analysis current and specific to the batch you’re buying, or just taken from years ago? Was the product packaged and shipped with attention to contamination or conditions that could compromise quality? In my experience, responsible suppliers welcome these questions. The ones cutting corners dodge them.
Risk never drops to zero, but transparency and traceability drive it down. Accepting anything less, especially for drug development or clinical research, just paves the way for headaches and liability. Reliable products come with paperwork, batch tracing, and support from real people who know what’s at stake in your work.
If you’re not sure if a product is suitable for your application, contact the supplier directly. Ask for the certificate of analysis, traceability documents, and details about how it’s handled. Ask around in your professional network, too. Most labs share supplier experiences, good and bad, much more willingly than manufacturers expect.
In the end, safety, compliance, and scientific rigor can’t be just buzzwords. They’re the foundation of good research and safe medicine. Cutting corners erases trust, slows progress, and eventually costs everyone a lot more than a small upfront saving.
Early on in my career, I always looked forward to taking samples from chemical drums for lab work. Sometimes the sizes didn’t match our needs, which left us struggling to transfer excess material or pay for chemicals we’d never use. With specialized compounds like (1R,2R)-(+)-1,2-Cyclohexanediamine L-tartrate, the packaging sizes tell a lot about intended audiences and real-life usability. This compound acts as a chiral building block—whether in pharmaceuticals, agrochemical development, or academic research, labs value precision and minimum waste. Someone working in discovery research in a university might only need a few grams, but a company scaling a synthetic API needs something a lot bigger.
Most chemical suppliers offer a range of sizes. Typical choices include small bottles from 1 gram to 25 grams for bench-scale work. These suit chemists validating new reactions or screening catalysts. Lab managers watch budgets closely, and smaller bottles mean less sunk cost.
As the quantity demand grows, 100-gram and 500-gram bottles become staples for kilo lab projects and continuous process development. It’s not uncommon to find this tartrate salt packed in 1 kg jars or even 5 kg containers at the larger end, often for pilot plant work or commercial batch synthesis. From personal experience in kilo labs, those 500 g to 1 kg units hit the sweet spot—convenient enough to use sparingly, but large enough to serve several rounds of process trials.
Bulk chemical buyers step into another league. Custom packaging for orders above 10 kg usually centers on either sealed polyethylene bags within cardboard drums or high-strength containers that guard against moisture and cross-contamination. Some manufacturers will even ship in 25 kg drums if the project needs justify it. From my own work with contract manufacturers, specifying packaging here comes down to supplier flexibility, customer site capabilities, and clear communication around purity standards.
Few things matter more than safety and product integrity. L-tartrate salts absorb moisture easily. Suppliers often pack them with tight-sealing caps or lined foil pouches, especially for small and medium containers. Larger packages rely on thick-walled containers and double-bagging.
Managing packaging serves more than organizational neatness—it protects researchers, keeps products reliable, and even helps with compliance. Every time I saw labs using poorly labeled or repackaged chemicals, I saw mistakes: product wasted, projects delayed, or worse, exposure risks. Manufacturers who choose secure, tamper-evident, and moisture-resistant containers actually make life better for users down the line.
Over the last few years, sustainable packaging in specialty chemicals started to gather attention. Suppliers now sometimes accept requests for take-back programs, reusable drums, or lightweight recyclable plastics. My team started requesting bulk product in fewer, larger units to reduce the volume of non-biodegradable plastic waste. More vendors should follow this trend, since it aligns with both lab demands and broader industry targets.
Contacting a supplier with clear intentions saves time. I recommend discussing exact use levels, intended shelf life, and site storage capacity. Most catalogues list several sizes, but requests for alternate packaging often get accommodated—especially from established customers. Technical support teams can offer insights on shelf life, shipping best practices, and sometimes arrange split shipments to help keep sensitive compounds in top shape.
Product stewardship comes full circle through practical packaging. Picking the right size pays off in safety, quality, and less environmental impact.
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