Chemical Name: 1-propanol, 2-chloro-, (2R)-
Synonyms: (R)-2-Chloro-1-propanol, (R)-Chlorohydrin
CAS Number: 57090-45-6
Molecular Formula: C3H7ClO
Molecular Weight: 94.54 g/mol
Recommended Use: Laboratory research, chemical synthesis
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GHS Classification: Acute toxicity (oral, dermal, inhalation), Skin corrosion/irritation, Serious eye damage/irritation, Specific target organ toxicity
Pictograms: GHS06 (skull and crossbones), GHS05 (corrosive), GHS07 (exclamation mark)
Signal Word: Danger
Hazard Statements: Toxic if swallowed; Harmful if inhaled; Causes severe skin burns and eye damage
Precautionary Statements: Avoid inhalation, ingestion, and contact with skin and eyes. Wear appropriate PPE. Use only in well-ventilated areas.
Chemical: 1-propanol, 2-chloro-, (2R)-
Content: ≥98%
Impurities: Water (<1%), other organic compounds (<1%)
Occupational Exposure Limits: No specific value; handle with caution due to toxic effects
Inhalation: Move the person to fresh air. Provide artificial respiration if not breathing or use oxygen if breathing is difficult. Call a medical professional immediately.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of water for at least 15 minutes. Consult a physician promptly.
Eye Contact: Rinse thoroughly with water for at least 15 minutes, lifting eyelids occasionally. Seek immediate medical attention.
Ingestion: Do NOT induce vomiting. Rinse mouth with water. Never give anything by mouth to an unconscious person. Call a physician right away.
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, or alcohol-resistant foam.
Unsuitable Extinguishing Media: Do not use water jet.
Specific Hazards: Releases hydrogen chloride and phosgene gas on decomposition. May form explosive mixtures with air when vaporized.
Protective Equipment: Full protective suits, self-contained breathing apparatus required for fire service personnel.
Firefighting Instructions: Stay upwind and avoid breathing vapors. Use water spray to cool closed containers at risk of explosion.
Personal Precautions: Evacuate non-essential personnel. Ventilate area well. Wear protective clothing, gloves, safety eyewear, and appropriate respiratory protection.
Environmental Precautions: Prevent further leakage or spillage where safe to do so. Do not allow chemical to enter drains, watercourse, or soil.
Cleanup Methods: Absorb with inert material (earth, sand). Sweep up and collect in suitable, tightly closed containers for disposal. Wash area with copious water. Dispose of all cleanup materials responsibly.
Handling: Always handle in a chemical fume hood. Avoid skin, eye, and clothing contact. Refrain from eating, drinking, or smoking in the work area. Wash hands thoroughly after handling.
Storage: Store in tightly closed containers in a cool, dry, well-ventilated place away from incompatible substances including strong oxidizers, strong acids, and bases. Label containers clearly and keep away from sources of ignition or heat.
Engineering Controls: Use chemical fume hoods, local exhaust, and work in well-ventilated areas.
Personal Protective Equipment: Chemical safety goggles or face shields, butyl rubber or nitrile gloves, laboratory coats, and, if the potential for exposure exists, use of a respirator (with organic vapor cartridge or positive pressure supplied air mask).
Hygiene Measures: Wash hands before breaks and after work. Remove contaminated clothing immediately.
Appearance: Clear, colorless to pale yellow liquid
Odor: Penetrating, pungent, characteristic
Boiling Point: 155–157°C
Melting Point: -52°C
Flash Point: 70°C
Solubility: Miscible with water and most organic solvents
Vapor Pressure: 2.1 mmHg at 25°C
Density: 1.10 g/cm³ at 20°C
pH: Not applicable (neutral in solution)
Chemical Stability: Stable under recommended storage conditions.
Reactivity: Reacts with strong oxidizing agents, bases, and acids.
Hazardous Decomposition Products: Hydrogen chloride, phosgene, carbon monoxide, carbon dioxide released under fire conditions.
Conditions to Avoid: Heat, sparks, open flames, sources of static discharge, incompatible chemicals, moisture.
Acute Toxicity: Harmful by oral, dermal, and inhalation exposure. May cause respiratory tract irritation, nausea, headache, and dizziness. Toxic dose for rats (oral LD50): ~320 mg/kg.
Chronic Effects: Risk of liver and kidney injury with long-term or repeated exposure.
Symptoms of Exposure: Skin and eye burns, cough, shortness of breath, abdominal pain, convulsions at high doses.
Sensitization/Carcinogenicity: No known data on carcinogenicity, mutagenicity, or sensitization.
Aquatic Toxicity: Toxic to aquatic organisms. LC50 for fish (96 h): approx. 45 mg/L.
Persistence/Degradability: Moderate persistence in water; photodegrades and biodegrades under exposure to sunlight and bacteria.
Bioaccumulation Potential: Low, but may still accumulate under concentration exposure.
Effects: May cause disruptions in aquatic ecologies and affect non-target organisms.
Waste Treatment Methods: Dispose of in accordance with local, state, and federal regulations. Do not pour down drains or dispose of with household garbage.
Contaminated Packaging: Rinse containers several times before disposal. Treat as hazardous waste.
Disposal Precautions: Use certified hazardous waste disposal contractors. Incineration is preferred method.
UN Number: UN 2735
UN Proper Shipping Name: Amines, liquid, corrosive, n.o.s. (contains 1-propanol, 2-chloro-, (2R)-)
Transport Hazard Class: Class 8 (corrosive liquids)
Packing Group: III
Marine Pollutant: Yes
Handling Requirements: Ensure containers are upright, sealed, labeled for hazardous contents, and handled by trained personnel only.
TSCA (US): Listed
EINECS (EU): Listed
OSHA Hazards: Corrosive, toxic
SARA Title III: Covered under Section 313 (Toxic Chemical Release Inventory Reporting)
California Proposition 65: Not listed
Other Regulations: Workers must use according to local and international guidelines to minimize exposure and environmental impact.
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