Material Safety Data Sheet for 1-Phenoxy-2,3-propanediol

Identification

Product Name: 1-Phenoxy-2,3-propanediol
Chemical Formula: C9H12O3
Synonyms: Glyceryl Phenyl Ether, 2,3-Dihydroxypropyl Phenyl Ether
CAS Number: 7705-10-8
Recommended Use: Chemical intermediate, solvent, pharmaceutical applications
Supplier Identification: Name, address, and emergency contact details supplied on the label
Emergency Phone: Available 24/7 through manufacturer or local poison control center

Hazard Identification

Classification: Not classified as hazardous under GHS guidelines for typical handling
Labeling Elements: Signal word not required; no pictograms assigned for GHS
Hazard Statements: Some eye and skin irritation reported with direct contact
Precautionary Statements: Avoid contact with skin and eyes, use in well-ventilated locations, do not ingest
Potential Health Effects: Eye irritation, mild skin discomfort, possible respiratory irritation if mist inhaled
Environmental Impact: Possible mild aquatic toxicity in high concentrations based on structurally similar substances

Composition / Information on Ingredients

Chemical Name: 1-Phenoxy-2,3-propanediol
Concentration: More than 98% w/w as pure chemical
Impurities: Less than 2% unidentified by-products or related esters typical for the synthesis process
EC Number: 231-723-7,
Molecular Weight: 168.19 g/mol

First Aid Measures

Inhalation: Move person to fresh air, monitor breathing, seek medical attention if coughing or respiratory symptoms persist
Skin Contact: Wash affected area thoroughly with soap and water, remove contaminated clothing, seek care if irritation develops
Eye Contact: Rinse gently with plenty of water for at least 15 minutes, keep eyelids apart, remove contact lenses if present, consult physician if irritation persists
Ingestion: Rinse mouth, avoid inducing vomiting, drink water, call physician or poison control immediately
Oversight: Never provide anything by mouth to unconscious individuals, observe for any allergic reaction symptoms, record exposure details for medical responders

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, foam, dry chemical powder, water spray
Unsuitable Media: High-pressure water jets may spread chemical
Specific Hazards: May release phenol fumes, carbon monoxide, carbon dioxide under combustion, slight fire risk as heated
Protective Equipment: Wear self-contained breathing apparatus, fire-resistant suit, keep containers cool with water spray, evacuate unnecessary personnel
Special Precautions: Prevent run-off into drains, apply firefighting water sparingly to avoid chemical spread

Accidental Release Measures

Personal Protection: Use gloves, goggles, chemical-resistant clothing, ventilate affected area
Environmental Precautions: Prevent chemical spill from entering drains, surface waters, or soil
Methods for Cleanup: Contain and absorb spillage with inert material like sand or earth, shovel into labeled waste containers for disposal, clean residue with water
Emergency Procedures: Remove ignition sources, evacuate area if spill is large, follow local regulations for further decontamination
Reporting: Notify local authorities if major environmental exposure, especially in case of spill into waterways

Handling and Storage

Safe Handling: Use with adequate ventilation, avoid direct contact with skin and eyes, practice good laboratory hygiene
Protection Measures: Carry only in original or suitable secondary containers sealed tightly, avoid breathing vapor or mist
Conditions for Storage: Store at room temperature, away from heat, ignition sources, and incompatible chemicals like strong oxidizers and acids
Storage Requirements: Keep in a dry, cool, well-ventilated place, out of direct sunlight, container tightly closed
Incompatibilities: Segregate from oxidizing substances, prevent exposure to acids and bases

Exposure Controls and Personal Protection

Exposure Limits: No workplace exposure limit established for this compound
Engineering Controls: Use fume hood or local exhaust, maintain safety shower and eyewash nearby
Personal Protective Equipment: Chemical goggles, gloves (nitrile or similar), lab coat, safety shoes
Respiratory Protection: Wear approved respirator if aerosol or mist is generated
Control of Environmental Exposure: Waste containment for all spills, regular equipment decontamination, monitor for vapor buildup in storage
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke near the chemical

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid with faint, sweet odor
Boiling Point: 283-295 °C (uncorrected)
Melting Point: -16 °C (approximate value)
Flash Point: 143 °C (closed cup)
Auto-ignition Temperature: No data available
Vapor Pressure: Low, less than 0.01 mmHg at 25 °C
Solubility: Soluble in water, alcohol, and many polar organic solvents
Density: 1.16 g/cm³ at 25 °C
Viscosity: Moderate
Odor Threshold: Not determined
pH: Slightly acidic in solution

Stability and Reactivity

Chemical Stability: Stable under normal storage conditions, no hazardous polymerization expected
Conditions to Avoid: Heat, open flame, direct sunlight, strong oxidizing conditions
Materials to Avoid: Strong acids, strong bases, oxidizers
Hazardous Decomposition Products: Combustion forms carbon monoxide, carbon dioxide, possible phenol derivatives
Reactivity Hazards: Reactive with oxidizers, forms peroxides slowly on long exposure to air

Toxicological Information

Acute Toxicity: Low acute oral and dermal toxicity in animal studies, LD50 values not significantly low
Skin/Eye Irritation: May cause mild irritation with direct contact, not a known sensitizer
Respiratory Effects: Inhalation of high concentrations of vapor or mist may cause mild respiratory irritation
Long-term Exposure: No major chronic toxicity reported; long-term studies limited
Mutagenicity: Not known to be mutagenic in standard in vitro tests
Carcinogenicity: No evidence in long-term animal studies; not listed as a carcinogen by IARC, NTP, or OSHA
Other Effects: Not known to cause reproductive or developmental harm

Ecological Information

Ecotoxicity: Low toxicity to aquatic life expected at typical usage concentrations, limited data from bioassays
Persistence: Biodegradable under aerobic conditions, slow breakdown in anaerobic conditions possible
Bioaccumulation: Low potential for bioaccumulation based on partition coefficient
Mobility in Soil: Moderate mobility predicted from water solubility, risk of leaching exists if spilled in large quantities
Other Environmental Effects: Breakdown products not expected to be more hazardous than parent substance

Disposal Considerations

Waste Handling: Collect in suitable labeled containers, don’t mix with incompatible waste streams
Methods of Disposal: Dispose through chemical waste incineration in accordance with local, regional, national, and international regulations
Recovery & Recycling: Recovery not practical for used or contaminated solutions, avoid drain disposal
Packaging: Containers should be triple-rinsed and disposed as hazardous chemical waste
Special Precautions: Consult local authority or chemical waste processor, always use personal protection during disposal activities

Transport Information

UN Number: Not regulated for transport by ground, sea, or air under most international codes
Proper Shipping Name: Not classified as dangerous goods
Transport Hazards: Avoid extreme temperatures, upright secure packaging, protect from crushing
Special Precautions: Standard chemical storage and carriage, keep away from food, animal feed, and incompatible chemicals
Packaging Group: No special group assignment

Regulatory Information

OSHA Status: Not classified as hazardous chemical under OSHA Hazard Communication Standard
SARA Title III: Not listed under Sections 302, 304, 311, or 312
TSCA: Listed on the U.S. Toxic Substances Control Act Inventory
REACH Status: Registered or pre-registered in EU chemical regulation system
Other International Regulations: No major restrictions noted in Canada (DSL/NDSL listed), Japan, Australia (AICS listed), or Korea
Labeling Requirements: Standard chemical hazard symbol not required for routine laboratory or industrial use
Other Regulatory Notes: Always review local, site-specific regulations as they may require additional risk management