Material Safety Data Sheet: 1-Chloro-3-t-Butylamino-2-propanol

Identification

Product Name: 1-Chloro-3-t-Butylamino-2-propanol
Chemical Formula: C7H16ClNO
Synonyms: 3-tert-butylamino-1-chloro-2-propanol; Chloro-t-butylaminopropanol
CAS Number: 32797-44-7
Recommended Uses: Intermediate for chemical synthesis, including pharmaceuticals
Supplier: [Supplier information as indicated on container label]
Emergency Phone Number: [Emergency contact as supplied with product registration]

Hazard Identification

Classification: Harmful if swallowed, causes serious eye irritation, may cause skin irritation
Signal Word: Warning
Hazard Statement(s): Can irritate eyes and skin; ingestion might harm internal organs; inhalation of dust or vapor may cause respiratory discomfort; risk of environmental contamination exists
Precautionary Statement(s): Wear safety goggles and gloves; wash thoroughly after handling; work only in well-ventilated zones; keep away from open flame and strong oxidizers
Hazard Pictograms: Exclamation mark, Health hazard
Other Hazards: Avoid breathing vapor or dust; avoid all unnecessary exposure; may react with acids or oxidizers, releasing toxic gases

Composition / Information on Ingredients

Chemical Name: 1-Chloro-3-t-Butylamino-2-propanol
Concentration: ≥98% by weight
Impurities: ≤2% unspecified organic and inorganic components
Additives: None reported
Molecular Weight: 165.66 g/mol

First Aid Measures

Inhalation: Move exposed person to fresh air; seek medical attention if breathing becomes difficult; provide oxygen if directed by healthcare provider
Skin Contact: Rinse skin immediately with plenty of water for at least 15 minutes; remove contaminated clothing; wash affected area with mild soap; consult doctor if irritation develops
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; medical evaluation is strongly advised
Ingestion: Rinse mouth with water; do not induce vomiting; never give anything by mouth to an unconscious person; immediate medical help is crucial
Most Important Symptoms/Effects: Burning sensation, coughing, difficulty breathing, headache, nausea, irritation of skin and eyes

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical, or foam
Specific Hazards: Releases toxic and irritating gases such as hydrogen chloride and nitrogen oxides upon combustion
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective fire-resistant clothing
Special Procedures: Avoid direct contact with substance; keep containers cool with water spray to prevent rupture; control runoff to minimize environmental exposure

Accidental Release Measures

Personal Precautions: Evacuate area, ventilate adequately, ensure use of PPE (gloves, goggles, respirator)
Environmental Precautions: Prevent contamination of soil, drains, sewers, and waterways; notify environmental authority if large releases occur
Clean-up Methods: Absorb with inert material (dry sand, earth); sweep or scoop into properly labeled chemical-waste container; complete clean-up with detergent and water, do not reuse contaminated absorbent

Handling and Storage

Handling: Keep tightly closed in original packaging; avoid generation of dust or aerosols; use only in environments with good ventilation; prevent contact with skin, eyes, and clothing
Storage: Store at ambient temperature in a dry, well-ventilated place away from incompatible materials (strong acids, oxidizers); keep away from direct sunlight and moisture; containers must be clearly labeled and checked regularly for leaks or signs of damage

Exposure Controls and Personal Protection

Engineering Controls: Local exhaust ventilation or chemical fume hood to minimize airborne exposure
Exposure Limits: No specific occupational exposure limits set; general exposure to similar chlorinated compounds should be minimized
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), tightly fitting safety goggles, long-sleeved lab coat, adequate respiratory protection in cases of inadequate ventilation
Hygiene Measures: Wash hands thoroughly after handling; do not eat, drink, or smoke while handling chemical

Physical and Chemical Properties

Appearance: Colorless to pale yellow liquid
Odor: Characteristic, mild amine-like
Odor Threshold: Data not available
pH: Neutral (approx. 7)
Melting Point/Freezing Point: -2°C (approximate)
Boiling Point: 180–190°C
Flash Point: 67°C (estimated, closed cup)
Evaporation Rate: Not established
Flammability: Not highly flammable
Explosion Limits: Not determined
Vapor Pressure: Low at room temperature
Relative Density: 1.03 g/cm³ (at 20°C)
Solubility: Miscible with water and most polar organic solvents
Partition Coefficient (log Pow): Estimated 0.2–0.5
Autoignition Temperature: Data not available

Stability and Reactivity

Reactivity: May react with acids, strong oxidizing agents, and strong bases
Chemical Stability: Stable under recommended storage and handling conditions
Hazardous Reactions: Possible release of toxic gases on heating or contact with incompatible materials
Conditions to Avoid: Excessive heat, sparks, open flame, direct sunlight, strong oxidants
Incompatible Materials: Strong oxidizers, strong acids, some metals
Hazardous Decomposition Products: Hydrogen chloride, nitrogen oxides, phosgene under fire conditions

Toxicological Information

Likely Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: Oral LD50 (rat) estimate: 800–1200 mg/kg; inhalation and dermal data limited
Skin Corrosion/Irritation: Moderate irritation possible
Serious Eye Damage/Irritation: Can cause redness and pain
Respiratory Sensitization: Inhalation of high doses causes cough, sore throat, dizziness
Chronic Effects: Prolonged or repeated exposure may lead to dermatitis, respiratory sensitization
Mutagenicity: No data available
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Other Information: Data on reproductive or developmental toxicity not available

Ecological Information

Toxicity to Aquatic Life: May be harmful to aquatic organisms at significant concentrations
Persistence and Degradability: Expected to degrade slowly in the environment
Bioaccumulative Potential: Low based on estimated log Pow
Mobility in Soil: May leach into groundwater; soluble in water
Other Adverse Effects: Risk of local environmental impact exists from accidental spills or leaks into waterways; data on chronic toxicity in the environment is limited

Disposal Considerations

Product Disposal: Dispose of in accordance with national and local regulations; a licensed waste disposal contractor should handle large volumes
Container Disposal: Triple rinse containers, then puncture and dispose of as hazardous waste
Other Recommendations: Do not discharge into drains, water courses, or onto the ground; incinerate if suitable facilities exist

Transport Information

UN Number: Not regulated under UN Model Regulations
ADR/RID: Not classified as hazardous for transport
IMDG: Not classified as dangerous goods for sea transport
IATA: Not regulated for air transport
Proper Shipping Name: 1-Chloro-3-t-Butylamino-2-propanol
Transport Hazard Class: Not assigned
Packing Group: Not applicable
Environmental Hazards: None known under standard conditions

Regulatory Information

TSCA: Listed or exempt
EINECS/ELINCS: Listed
Canada DSL/NDSL: Listed
OSHA HazCom: Hazardous chemical as defined by OSHA Hazard Communication Standard
REACH Status: Substance registered or exempted
SARA Title III Sections 302/311/312/313: Not subject to reporting
Other Regulatory Info: Chemical inventories should be checked for local registration; comply with country-specific chemical safety management rules; workers must have access to this data sheet during use