Product Name: 1-Chloro-3-Propanol
Synonyms: 3-Chloro-1-propanol, 3-Chloropropanol
CAS Number: 627-30-5
Molecular Formula: C3H7ClO
Molecular Weight: 94.54 g/mol
Manufacturer: Company contact information should be provided by supplier.
Recommended Use: Chemical intermediate, research, or synthesis
Restrictions on Use: Not for food, drug, or household applications
GHS Classification: Acute Toxicity (oral, dermal, inhalation), Eye Irritation, Skin Irritation, Specific Target Organ Toxicity
Signal Word: Danger
Hazard Statements: Harmful if swallowed; Causes skin irritation; Causes serious eye damage; Harmful if inhaled; May cause respiratory irritation
Pictograms: Exclamation mark, Health hazard, Corrosive
Precautionary Statements: Avoid breathing vapors; Wear protective gloves, clothing, and eye/face protection; Wash thoroughly after handling; Do not eat, drink, or smoke during use; Use only outdoors or in a well-ventilated area
Routes of Exposure: Inhalation, ingestion, skin, and eyes
Potential Health Effects: Inhalation may trigger coughing or respiratory discomfort; skin contact often produces reddening or burns; eye contact can result in pain and lasting injury; accidental ingestion leads to digestive irritation and possible systemic toxicity
Substance: 1-Chloro-3-Propanol
CAS Number: 627-30-5
EC Number: 210-990-1
Concentration: >99%
Impurities and Additives: Generally limited to water or trace byproducts from synthesis, can influence hazard severity
General Advice: Remove source of exposure immediately while protecting yourself; seek medical attention without delay
Inhalation: Take victim to fresh air; support breathing as needed; rest in a position easy for breathing; medical attention required
Skin Contact: Wash thoroughly with soap and water for fifteen minutes or longer; take off contaminated clothing right away; obtain medical help if irritation persists
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing and urgently consult an ophthalmologist
Ingestion: Rinse mouth thoroughly; do not induce vomiting; give water if conscious; seek immediate medical advice
Important Symptoms/Effects: Redness, burning sensation, coughing, sore throat, abdominal discomfort, vision changes, drowsiness, headache
Immediate Medical Attention: Always consult with poison control or emergency physicians for further instructions
Suitable Extinguishing Media: Dry chemical powder, alcohol-resistant foam, carbon dioxide, water spray for larger fires
Unsuitable Media: Straight water streams can spread chemicals; do not use if not compatible with charged electrical equipment
Hazards from Combustion: Releases toxic vapors including HCl, phosgene, carbon monoxide, and carbon dioxide
Protective Equipment: Full body suit, SCBA (self-contained breathing apparatus), chemical-resistant boots and gloves
Special Procedures: Move containers away from fire zone if safe; use water to keep cool; prevent fire-fighting water runoff from entering drains or waterways; fight fire from safe distance
Other Information: Vapors can accumulate in low-lying areas posing explosive risk; hazardous decomposition may occur on exposure to flames
Personal Protection: Evacuate area if needed; use proper respirators, gloves, splash goggles, and full protective clothing
Emergency Procedures: Alert local authorities; ventilate closed spaces; control sources of ignition
Containment: Prevent runoff into sewers, storm drains, or waterways; contain spill with inert absorbent material such as sand or vermiculite
Clean-up: Soak up with non-combustible absorbent; collect in sealable chemical waste containers; wash spill area thoroughly after removal
Decontamination: Avoid direct contact during cleanup; clearance should be checked by skilled personnel
Handling Precautions: Use only in well-ventilated areas; avoid inhaling vapors; minimize skin, eye, and clothing contact; never consume food or drink near working area
Safe Storage Conditions: Store in tightly closed containers made of compatible material; keep in cool, dry, well-ventilated warehouses; segregate from oxidizers, acids, or incompatible metals
Protective Measures: Use corrosion-resistant storage shelves and materials; always label containers clearly for identification
Incompatible Materials: Acids, oxidizers, strong bases, reactive metals
Other Guidance: Ensure access to emergency eyewash stations, safety showers; regular inspection of storage containers helps prevent leaks or deterioration
Occupational Exposure Limits: No occupational exposure limits have been established by OSHA, ACGIH, or NIOSH, but careful controls are important
Engineering Controls: Local exhaust ventilation, chemical fume hoods, and splash protection barriers
Personal Protective Equipment (PPE): Chemical-resistant gloves such as nitrile or butyl, safety glasses or goggles with side shields, impermeable lab coats or aprons, properly fitted respirators when airborne exposures cannot be controlled
Hygiene Measures: Wash hands and face after handling, remove contaminated clothing, prohibit eating, drinking, or smoking in the exposure area
Environmental Controls: Limit releases to environment with spill containment systems or closed transfer processes
Special Precautions: Monitoring exposure with personal or fixed detectors in case evaporation or leaks may occur, maintain strict storage controls in shared laboratory or plant settings
Appearance: Colorless to pale yellow liquid
Odor: Mild, slightly pungent alcohol odor
Odor Threshold: Information not available
pH: Neutral (does not dissociate in water as acid or base)
Melting Point: -53°C
Boiling Point: 156-158°C
Flash Point: 70°C (closed cup)
Evaporation Rate: Data not specified
Flammability: Not classified as highly flammable but vapors can form explosive mixtures
Upper/Lower Flammability Limits: Not established
Vapor Pressure: 1.1 mmHg @ 25°C
Vapor Density: 3.3 (air=1)
Relative Density: 1.147 g/cm³ @ 25°C
Solubility in Water: Completely miscible
Partition Coefficient: log Kow = -0.61 (estimated)
Decomposition Temperature: Not specified
Viscosity: Not reported
Auto-ignition Temperature: 320°C
Chemical Stability: Stable at room temperature under recommended storage conditions
Possibility of Hazardous Reactions: Reacts with acids, bases, oxidizing agents
Conditions to Avoid: Heat, open flame, direct sunlight, moisture, strong oxidizers, and incompatible chemicals
Incompatible Materials: Strong acids, strong bases, alkali metals, reducing agents, strong oxidizers
Hazardous Decomposition: Hydrogen chloride, phosgene, carbon oxides produced during fire or thermal decomposition
Acute Toxicity: Oral LD50 (rat): ~150 mg/kg; may lead to severe systemic effects or fatality after large ingested doses
Inhalation: Causes airway irritation, coughing, headache; systemic effects possible at high concentrations
Skin Contact: Induces redness, burning, and possible blistering after prolonged or repeated exposure
Eye Contact: Significant irritation, redness, tearing, risk of serious injury
Chronic Effects: Repeated or prolonged exposure may impact liver and kidney, potential neurotoxicity if not controlled
Carcinogenicity: Not classified by IARC, NTP, or OSHA as a carcinogen at present; animal studies remain incomplete
Other Data: Mutagenicity and reproductive toxicity data inconclusive, but prudence suggests minimized personal and workplace exposures
Environmental Fate: Rapidly mobile in soil and water, does not tend to bioaccumulate due to low log Kow; readily biodegradable in aquatic systems but releases can affect ecosystem chemistry
Ecotoxicity: Harmful to aquatic organisms, both acute and chronic LC50 values in freshwater fish and daphnia reported at moderate concentrations
Persistence and Degradability: Expected to degrade in days to weeks; hydrolysis and photolysis possible
Mobility in Soil: May leach to groundwater; management practices should prevent spills and leaks in outdoor environments
Other Adverse Effects: Release to surface waters triggers short-term oxygen demand and impacts aquatic flora and fauna, especially sensitive invertebrates
Waste Disposal Methods: Treat as hazardous chemical waste; incineration in licensed facilities recommended; comply with local, state, and federal hazardous waste laws
Container Disposal: Triple-rinse empty containers; puncture and dispose in accordance with environmental regulations
Special Instructions: Do not flush to drains, surface water, or soil; avoid actions likely to vaporize or aerosolize waste
Precautions: Waste handlers need full PPE, including respirators and chemical-resistant clothing; documentation required for waste tracking
UN Number: 2810
UN Proper Shipping Name: Toxic liquid, organic, n.o.s. (contains 1-Chloro-3-Propanol)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Hazard Labels: Toxic, miscellaneous
Special Transport Precautions: Secure containers in upright position, prevent leaks, avoid transport with incompatible goods like foods or strong oxidizers; emergency response instructions on-hand during shipment
Regulatory Notes: Comply with DOT, IMDG, IATA transport codes and local jurisdiction requirements
US Federal Regulations: Not listed as a specific hazard under SARA Title III or CERCLA; subject to OSHA Hazard Communication Standard for hazardous chemicals
State Regulations: Reportable under right-to-know rules in certain states such as New Jersey and Pennsylvania
International Regulations: Listed or notified in many national inventories (TSCA, EINECS, DSL, etc.)
Labeling Requirements: Ensure all storage and shipping containers labeled per GHS and local jurisdiction requirements
Other Compliance: Recordkeeping and incident reporting mandatory in workplace; industrial facilities must review classification and safety controls with workers
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