Material Safety Data Sheet: 1-Aminopropanediol

Identification

Product Name: 1-Aminopropanediol
Chemical Name: 1-Amino-2-propanol
Synonyms: 2-Hydroxy-1-aminopropane, Monoisopropanolamine
CAS Number: 78-96-6
EC Number: 201-168-3
Recommended Use: Intermediate for chemical synthesis, pH control agent, surfactant production
Supplier Name: Contact chemical distributor or manufacturer for specifics
Emergency Contact: Local emergency numbers or supplier emergency hotline

Hazard Identification

Classification: Eye irritation – Category 2, Skin irritation – Category 2, Specific target organ toxicity (single exposure) – Category 3
Label Elements: Signal word: Warning
Hazard Statements: Causes skin and eye irritation, May cause respiratory irritation, Harmful if swallowed
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing mist, vapours, wash skin thoroughly after handling, use only outdoors or with adequate ventilation, wear protective gloves, eye and face protection

Composition / Information on Ingredients

Chemical Identity: 1-Aminopropanediol
Concentration: 98-100% by weight
Impurities: Minor water content, possible traces of diols depending on synthesis
CAS Number: 78-96-6

First Aid Measures

Inhalation: Move exposed person to fresh air, keep at rest in a position comfortable for breathing, seek medical attention for persistent irritation or difficulty breathing
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with plenty of water, contact physician if irritation or redness develops and persists
Eye Contact: Rinse cautiously with water for at least 10-15 minutes, remove contact lenses if present and easy to do, seek immediate medical attention for persistent pain, redness, or visual disturbances
Ingestion: Rinse mouth, give small amount of water if the person is fully conscious, do not induce vomiting, seek medical advice

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, alcohol-resistant foam, carbon dioxide
Unsuitable Extinguishing Media: Direct water jet may scatter material
Hazards from Combustion: Releases toxic fumes of nitrogen oxides, carbon oxides, ammonia during combustion
Protective Equipment: Full protective gear and self-contained breathing apparatus for firefighting
Specific Methods: Use water spray to cool exposed containers, avoid run-off entering sewers or waterways

Accidental Release Measures

Personal Precautions: Use suitable personal protective equipment including gloves and goggles, provide adequate ventilation, avoid breathing vapour or mist
Environmental Precautions: Prevent further leakage if safe, keep chemical out of drains, surface water, and soil
Spill Cleanup Methods: Absorb with inert material such as sand or vermiculite, collect in closed, labelled containers for waste disposal, clean spill area with water and detergent, avoid direct contact with skin or eyes during cleanup

Handling and Storage

Safe Handling: Handle in well-ventilated areas, keep containers tightly closed, prevent inhalation of vapours, avoid skin and eye contact, use only with proper protective equipment
Storage Conditions: Store in original, tightly sealed containers in cool, dry, ventilated area, keep away from strong acids, oxidizers, and foodstuffs
Incompatibles: Strong oxidizing agents, strong acids, avoid contact with copper, aluminum, zinc, and their alloys
Special Requirements: Maintain good industrial hygiene practices, do not eat, drink, or smoke when using the product

Exposure Controls and Personal Protection

Occupational Exposure Limits: No specific national occupational exposure limit set, monitor airborne concentration in workplace
Engineering Controls: Provide local exhaust or general dilution ventilation to keep airborne levels below exposure limits
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile, neoprene), eye protection (safety goggles, face shield), protective clothing (long sleeves, lab coat), use a respirator if ventilation is insufficient
Hygiene Measures: Wash hands after handling, do not touch face or rub eyes during use, launder contaminated clothing before reuse

Physical and Chemical Properties

Appearance: Clear or slightly yellow, viscous liquid
Odour: Ammonia-like or fishy
Odour Threshold: Not established
pH: Strongly alkaline in solution
Melting Point: -2°C
Boiling Point: 213°C
Flash Point: 107°C (closed cup)
Evaporation Rate: Not determined
Flammability: May burn on strong heating
Explosive Limits: Not established
Vapour Pressure: <0.01 mmHg at 20°C
Vapour Density: 2.1 (air = 1)
Solubility: Miscible with water
Partition Coefficient (n-Octanol/Water): log Kow -1.66
Autoignition Temperature: 390°C
Decomposition Temperature: Not available
Viscosity: 56 cP at 20°C

Stability and Reactivity

Stability: Stable under normal temperatures and storage conditions
Incompatible Materials: Strong oxidizers, strong acids, materials containing copper, zinc, or aluminum may react with the product
Hazardous Decomposition Products: Ammonia, carbon monoxide, carbon dioxide, nitrogen oxides
Hazardous Reactions: Can react with strong oxidizers causing fire and explosion risk, can corrode metals

Toxicological Information

Likely Routes of Exposure: Inhalation, skin, eye, ingestion
Acute Toxicity (Oral LD50, rat): 2150 mg/kg
Acute Toxicity (Dermal LD50, rabbit): 2100 mg/kg
Skin Corrosion/Irritation: Causes irritation
Serious Eye Damage/Irritation: Causes irritation
Sensitization: Not expected to cause skin or respiratory sensitization
Chronic Effects: No evidence for carcinogenicity, mutagenicity, or reproductive toxicity in humans
Other Information: Overexposure may cause headaches, dizziness, nausea due to vapour inhalation

Ecological Information

Ecotoxicity: Harmful to aquatic life with long-lasting effects
Aquatic Toxicity (Fish, LC50, 96h): 193 mg/L (Oncorhynchus mykiss)
Invertebrate Toxicity (Daphnia EC50, 48h): 65 mg/L
Algae (EC50, 72h): 49 mg/L
Persistence and Degradability: Readily biodegradable, but high concentrations might affect aquatic organisms
Bioaccumulation Potential: Low, log Kow -1.66
Soil Mobility: High, will leach into groundwater if spilled
Other Adverse Effects: Neutralizes acid in bodies of water, could affect pH if discharged in high quantity

Disposal Considerations

Waste Disposal Methods: Dispose of in accordance with applicable local/regional/national regulations
Hazardous Waste: Not classified as hazardous under RCRA, but follow standard hazardous chemical disposal practice
Container Handling: Triple-rinse containers before disposal or recycling, puncture to prevent reuse
Prohibited Disposal: Never pour into drains, surface water, or soil
Incineration: Chemical incinerator with afterburner and scrubber recommended for large quantities
Environmental Precautions: Avoid uncontrolled release and report major spills to environmental authorities

Transport Information

UN Number: Not classified as hazardous for transport
Proper Shipping Name: Not regulated
Transport Hazard Classes: Not regulated for road, rail, air, or sea transport
Packing Group: No assignment
Special Precautions: Keep containers upright, secure cargo to avoid damage and leaks
Transport Labels: No specific hazard labels required

Regulatory Information

OSHA Status: Not specifically regulated
TSCA (USA): Listed
REACH (EU): Registered
SARA 311/312 Hazards: Immediate (acute) health hazard
California Proposition 65: No listed chemicals
WHMIS (Canada): Classified as D2B – Toxic material causing other toxic effects
Other International Inventories: Complies with AICS (Australia), DSL (Canada), ENCS (Japan), ECL (Korea), PICCS (Philippines), IECSC (China)