Product Name: 1,3-Propanediol
Chemical Formula: C3H8O2
Synonyms: Trimethylene Glycol, PDO
CAS Number: 504-63-2
Recommended Use: Used in the production of polytrimethylene terephthalate, solvents, antifreeze, adhesives, cosmetics, and cleaning agents
Restrictions: Not recommended for food or pharmaceutical use unless specially manufactured and validated.
Manufacturer Information: Company details including address, emergency phone number, and email.
GHS Classification: Eye Irritation (Category 2A), Not classified as flammable liquid, Not acutely toxic by oral, dermal, or inhalation exposure
Label Elements: Exclamation mark symbol, Signal word: Warning
Hazard Statements: Causes serious eye irritation
Precautionary Statements: Avoid contact with eyes, wash hands thoroughly after handling, wear eye protection
Potential Health Effects: Eye contact may result in redness and pain, skin contact may cause mild irritation, ingestion and inhalation exposure at normal use unlikely to result in acute symptoms
Environmental Effects: Low toxicity to aquatic organisms, still avoid release to the environment due to possible long-term effects.
Chemical Name: 1,3-Propanediol
Concentration: ≥99% by weight
Impurities: Water (<1%), trace organic byproducts from manufacturing
Molecular Weight: 76.09 g/mol
Mixture: Product is a pure substance rather than a mixture.
General: Remove contaminated clothing, give fresh air, seek medical advice for persistent discomfort
Eye Contact: Rinse cautiously with plenty of water for at least 15 minutes, remove contact lenses, continue rinsing, get medical attention if irritation persists
Skin Contact: Wash with plenty of soap and water, remove contaminated clothing, if irritation occurs get medical advice
Inhalation: Move to fresh air, respiratory symptoms generally not anticipated at ambient exposure, seek attention if symptoms develop
Ingestion: Rinse mouth with water, never give anything by mouth to an unconscious person, do not induce vomiting unless instructed by medical personnel, seek medical advice if large quantity ingested or symptoms occur.
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Specific Hazards: Product can form combustible mixtures, thermal decomposition may produce carbon monoxide and carbon dioxide
Protective Equipment for Firefighters: Full protective clothing, self-contained breathing apparatus, avoid inhalation of combustion gases
Additional Information: Cool exposed containers with water spray to prevent pressure build-up, fight fires from safe distance.
Personal Precautions: Use personal protective equipment, ventilate area, avoid inhalation and contact with skin or eyes
Environmental Precautions: Prevent product from entering drains, sewers, watercourses, or soil
Methods for Clean-Up: Absorb with inert material such as sand or earth, place in suitable containers for disposal, wash spill site after material pick-up is complete
Notification: Report large releases to appropriate environmental authorities, follow local regulations for reporting and remediation.
Safe Handling Practices: Handle in well-ventilated area, avoid generation of mist or aerosol, wear protective equipment, avoid prolonged or repeated exposure
Hygiene Measures: Wash hands after use, avoid eating, drinking, or smoking during handling
Storage Conditions: Store in tightly closed containers, keep in cool, dry, well-ventilated area, protect against physical damage
Incompatibilities: Strong oxidizing agents, acids, and acid chlorides to prevent dangerous reactions or degradation.
Occupational Exposure Limits: No established workplace exposure limits for 1,3-propanediol, monitor exposure as for other polyols
Engineering Controls: Use general or local exhaust ventilation, keep concentrations below airborne exposure limits
Personal Protective Equipment (PPE): Wear chemical safety goggles, impervious gloves, protective clothing for potential skin contact
Respiratory Protection: Not generally required at normal workplace concentrations; use approved respirator with organic vapor cartridge if engineering controls insufficient or exposure above recommended guidelines
Environmental Controls: Use measures to prevent product release to the environment during use and disposal.
Appearance: Clear, colorless, viscous liquid
Odor: Mild, faintly sweet
Odor Threshold: Not available
pH: 7 (50 g/L at 20°C)
Melting Point/Freezing Point: -27°C (-16.6°F)
Boiling Point/Range: 214°C (417°F) at 1 atm
Flash Point: 127°C (261°F) (closed cup)
Evaporation Rate: Not determined
Flammability: Combustible liquid (not highly flammable)
Upper/Lower Flammability Limits: Not determined
Vapor Pressure: 0.07 mmHg at 25°C
Vapor Density: 2.6 (air = 1)
Relative Density: 1.05 g/cm³ at 20°C
Solubility: Miscible in water
Partition Coefficient (n-octanol/water): -0.92
Auto-Ignition Temperature: 400°C (752°F)
Decomposition Temperature: Not established
Viscosity: 56 mPa·s at 25°C
Chemical Stability: Stable under normal temperatures and pressures
Reactivity: No dangerous reactions known under normal use
Conditions to Avoid: Excessive heat, ignition sources, long-term exposure to air may promote slow oxidation
Incompatible Materials: Strong oxidizing agents, strong acids, acid chlorides
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, and other toxic vapors possible on combustion or thermal decomposition.
Polymerization: Does not occur.
Likely Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Toxicity: LD50 (oral, rat): 20,000 mg/kg; LD50 (dermal, rabbit): >5,000 mg/kg (low toxicity)
Skin Corrosion/Irritation: Mildly irritating at most
Serious Eye Damage/Irritation: Causes moderate to severe eye irritation
Respiratory or Skin Sensitization: Not a sensitizer in animal tests
Chronic Effects: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity in available studies
Other Data: Not listed by ACGIH, IARC, NTP, or OSHA as a carcinogen.
Ecotoxicity: LC50 (fish, 96h): >10,000 mg/L (low aquatic toxicity); EC50 (Daphnia, 48h): >1,000 mg/L
Persistence and Degradability: Readily biodegradable in the environment, breaks down by natural processes
Bioaccumulative Potential: Low potential due to low log Kow value and high solubility
Mobility in Soil: Expected to be highly mobile in soil due to water solubility
Other Environmental Effects: Dilute solutions present minimal risk, inappropriate large-scale releases could alter local water chemistry, disposal should avoid direct release to surface waters.
Methods of Disposal: Dispose in accordance with local, regional, and national regulations, do not pour residues into waterways or sewers
Contaminated Packaging: Rinse containers thoroughly and offer for recycling or disposal according to local requirements
Special Considerations: Small quantities can be flushed to treatment plant with large volumes of water, larger spills must be absorbed and landfilled according to chemical waste policy.
UN Number: Not regulated for transport
UN Proper Shipping Name: Not assigned
Transport Hazard Classes: Not classified as hazardous for land, sea, or air transport
Packing Group: Not defined
Environmental Hazards: Not a marine pollutant
Special Precautions: General chemical hygiene during loading, unloading, and transport, prevent container damage and leaks.
OSHA Classification: Not hazardous
TSCA Status: Listed in Toxic Substances Control Act inventory
Canada WHMIS Status: Not controlled product
REACH Registration: Registered substance in EU, subject to annual reporting
SARA Title III: Not subject to SARA 302, 304, 313 provisions
Other Regulations: Not subject to specific chemical lists for reporting or restriction, comply with all workplace safety, health, and environmental regulations that apply to chemical use and transport.
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