Product Name: 1,3-Propanediol, 2-methylene-
Chemical Formula: C4H6O
Recommended Use: Industrial applications, chemical synthesis, laboratory research
Synonyms: Methylenedioxymethanol, 2-Methylene-1,3-propanediol
CAS Number: 500-38-9
Supplier Information: Name, address, and contact number of manufacturer or distributor
Emergency Contact: Poison control center or manufacturer’s emergency hotline
Classification: Flammable liquid, Category 3; Acute toxicity, Category 4 (oral, dermal)
GHS Label Elements: Warning, flame icon, exclamation mark
Hazard Statements: May cause eye and skin irritation, harmful if swallowed, inhaled, or absorbed through skin, may cause respiratory tract irritation, flammable liquid and vapor
Precautionary Statements: Keep away from heat, sparks, open flames, use explosion-proof equipment, wear protective gear, avoid breathing vapor, use outdoors or in well-ventilated area
Chemical Name: 1,3-Propanediol, 2-methylene-
Concentration: ≥98% by weight
CAS Number: 500-38-9
Impurities: Typical trace byproducts include water, trace organic alcohols
Stabilizers/Additives: None identified for standard purity grade
Inhalation: Move person to fresh air, keep at rest, seek medical attention if symptoms persist, avoid further exposure and loosen tight clothing
Skin Contact: Remove contaminated clothing, wash affected area with soap and water, seek treatment for persistent irritation or burns
Eye Contact: Rinse eyes carefully with water for at least fifteen minutes, lift eyelids, seek medical help if symptoms do not resolve
Ingestion: Do not induce vomiting, rinse mouth with water, consult a physician promptly
Acute and Delayed Symptoms: Throat irritation, abdominal pain, dizziness, numbness around mouth, potential skin burns
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, avoid water spray on undiluted chemicals
Special Hazards: Vapors may form explosive mixtures with air, combustion yields irritating and toxic fumes including carbon monoxide
Firefighting Instructions: Evacuate area, isolate hazard, approach from upwind, use self-contained breathing apparatus and protective clothing
Explosion Hazard: Container may rupture in fire from pressure buildup, run-off may pose environmental risk
Protective Equipment: Helmet, fire-retardant coat, boots, gloves, full face-mask with appropriate filters
Personal Precautions: Remove ignition sources, provide adequate ventilation, use chemical-resistant gloves, avoid contact with skin and eyes
Spill Response: Contain spill, absorb with inert material such as sand or vermiculite, collect in tightly sealed containers for disposal
Environmental Precautions: Prevent entry into drains, waterways, or soil, notify local authorities in case of large discharge
Cleanup Methods: Wash residual area with water and neutral detergent, ventilate space, remove all contaminated materials as hazardous waste
Handling: Use only with adequate ventilation, ground transfer equipment for static discharge control, avoid inhaling vapors or mist, use splash-proof goggles and gloves, prohibit eating, drinking, or smoking near handling area
Storage: Keep container tightly closed in cool, dry, well-ventilated spaces away from sunlight, ignition sources, incompatible substances (strong oxidizers, strong acids), store below 30°C, maintain clear labels
Incompatibilities: Avoid contact with oxides, halogens, acids, alkalis, or heat-generating agents to prevent dangerous reactions
Special Requirements: Employ secondary containment for large storage, check storage vessels for corrosion regularly, keep emergency showers and eye stations accessible
Exposure Limits: No established OSHA or ACGIH limits; handle as potentially hazardous substance
Engineering Controls: Use fume hood or local exhaust, provide safety showers and eyewash stations
Personal Protection: Wear chemical-resistant gloves (nitrile or butyl rubber), splash goggles, lab coat, respiratory protection if aerosolized or if ventilation is inadequate
Hygiene Measures: Wash hands thoroughly after handling, do not touch face, do not reuse contaminated clothing, decontaminate all protective equipment after use
Monitoring Methods: Air sampling in work area, regular inspection of ventilation systems
Appearance: Colorless to pale yellow liquid
Odor: Mild, slightly sweet chemical odor
pH: Not determined (neutral to slightly acidic expected)
Melting Point: -56 °C
Boiling Point: Approx. 124 °C at 760 mmHg
Flash Point: Approx. 44 °C (closed cup)
Flammability: Flammable liquid
Autoignition Temperature: >300 °C
Vapor Pressure: 10 mmHg at 25 °C
Solubility: Miscible with water, alcohols, ethers
Density: 1.04 g/cm³ at 25 °C
Viscosity: Low, mobile liquid
Partition Coefficient (n-octanol/water): logKow ~ -0.7
Evaporation Rate: Moderate, typical for glycol derivatives
Chemical Stability: Stable under ordinary conditions, may polymerize under heat or in the presence of free radicals
Reactivity: Reacts with strong oxidizers and acids, forms explosive mixtures with air
Hazardous Reactions: Possibility of runaway reaction if mixed with incompatible substances, exothermic polymerization possible if heated
Decomposition Products: Carbon monoxide, carbon dioxide, acrid smoke if burned
Incompatible Materials: Strong acids, alkali metals, oxidizing agents
Conditions to Avoid: Heat, sparks, open flames, direct sunlight, moisture
Routes of Exposure: Skin absorption, ingestion, inhalation, eye contact
Acute Toxicity: LD50 oral (rat): estimated 3300 mg/kg; LD50 dermal (rabbit): estimated 2000 mg/kg
Symptoms: Irritation or burns to skin, eyes, upper respiratory tract; gastrointestinal discomfort, drowsiness, headache upon high doses
Chronic Effects: Data insufficient; potential for dermatitis or sensitization after prolonged/ repeated exposure
Carcinogenicity: Not listed by IARC, NTP, OSHA as carcinogen
Mutagenicity: No studies found assessing gene mutation potential
Reproductive Toxicity: Insufficient data, limit exposure in pregnant individuals
Environmental Hazards: May be hazardous in case of spillage in large quantities
Aquatic Toxicity: Expected moderate toxicity to aquatic life (EC50, Daphnia ~ >100 mg/L, fish 96h LC50 estimated >200 mg/L)
Persistence and Degradability: Biodegradable under aerobic conditions, breakdown products can include organic acids, carbon dioxide
Bioaccumulation Potential: Low based on logKow
Mobility in Soil: High water solubility increases risk of leaching
Other Adverse Effects: Avoid unintentional release, large loads may alter pH and disrupt aquatic life temporarily
Waste Disposal: Collect as hazardous chemical waste, use registered incineration companies, small quantities may be neutralized with water and disposed as per local regulation
Contaminated Packaging: Triple rinse containers, remove or deface labels, manage container as hazardous waste
Local Requirements: Follow state and federal statutes, chemical should not reach regular drains, landfill or open environment
Other Information: Seek advice from local environmental authorities, follow institution’s hazardous waste protocols
UN Number: UN 1993
Proper Shipping Name: Flammable liquid, n.o.s. (contains 1,3-Propanediol, 2-methylene-)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Label: Flammable liquid
Marine Pollutant: Not classified as marine pollutant for transport
Special Precautions: Ensure secure closure of containers, upright storage, emergency spill response kit in transport vehicle, comply with local and international standards for flammable liquids
TSCA Inventory: Listed or exempted
EC Inventory: Listed in EINECS (European List of Notified Chemical Substances)
Regulatory Classifications: Complies with OSHA Hazard Communication Standard (29 CFR 1910.1200) and REACH regulation
Labeling Requirements: GHS signal word, pictogram, hazard and preventive language as specified in lab safety protocols
Chemical Safety Assessment: Required for manufacturing and industrial use, consult on-site EHS officers for risk analysis
SARA Title III: Not subject to Section 313 reporting, inclusion may vary depending on concentration and use
Other Standards: Follow workplace safety requirements (local, state, international), update training and safety data annually
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