Product Name: 1,3-Propanediol, 2-bromo-2-nitro-
Other Names: 2-Bromo-2-nitro-1,3-propanediol, Bronopol
Recommended Use: Biocide, preservative in cosmetics and personal care products, antimicrobial in industrial water systems, paper mills, cooling water, and oil field operations
Manufacturer/Supplier: Refer to source or purchasing entity for current contact information
Emergency Contact: Manufacturer’s chemical emergency line; access local or national poison centers for immediate medical guidance
CAS Number: 52-51-7
UN Number: 3241 (for transport purposes)
GHS Classification: Acute Toxicity (Oral) Category 4, Acute Toxicity (Dermal) Category 4, Eye Damage/Irritation Category 1, Skin Corrosion/Irritation Category 2, Aquatic Acute Category 1
Signal Word: Danger
Hazard Statements: Harmful if swallowed or in contact with skin, causes serious eye damage, causes skin irritation, highly toxic to aquatic life
Precautionary Statements: Avoid release to environment, wash contaminated skin thoroughly, wear gloves and eye/face protection, do not eat or drink when using product, remove contaminated clothing and wash before reuse
Pictograms: Skull and crossbones, exclamation mark, corrosion, environment
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Chemical Name: 2-Bromo-2-nitro-1,3-propanediol
Chemical Formula: C3H6BrNO4
Concentration: ≥99% (for technical or industrial grade material)
Impurities: Trace levels of related glycol derivatives, moisture less than 0.1%, no listed stabilizers or additives
CAS Number: 52-51-7
Inhalation: Move person to fresh air, monitor for respiratory distress, seek medical attention if coughing or breathing difficulty persists
Skin Contact: Remove contaminated clothing, wash skin thoroughly with plenty of soap and water for at least 15 minutes, seek medical advice for persistent irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to remove, keep rinsing, obtain immediate medical care
Ingestion: Rinse mouth, do not induce vomiting, provide water to dilute only if person is conscious, seek prompt medical help
Symptoms and Effects: Irritation to skin, staining, burning in mouth and throat, pain and redness in eyes, gastrointestinal upset
Note to Physicians: Treat symptomatically, monitor vital signs, consider delayed pulmonary effects
Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray
Unsuitable Extinguishing Media: Do not use direct water jet on large molten pools
Specific Hazards: Can decompose upon heating releasing toxic gases including nitrogen oxides, bromine vapors, and carbon oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Advice for Firefighters: Keep upwind, prevent runoff from entering waterways, use water spray to cool containers
Combustion Products: Nitrogen oxides, hydrogen bromide, carbon oxides, potentially formaldehyde
Personal Precautions: Wear chemical-resistant gloves, goggles, protective clothing, avoid breathing dust or vapors, evacuate unnecessary personnel
Environmental Precautions: Prevent spillage from entering drains, surface water or soil; report to appropriate authorities if significant environmental contamination occurs
Cleanup Methods: Collect spillage mechanically, use inert absorbent for residues, transfer to sealed container for disposal
Decontamination: Wash contaminated area with water and detergent after bulk removal
Disposal: Dispose via licensed chemical waste disposal contractor using methods compliant with local regulations
Safe Handling: Avoid skin and eye contact, handle in well-ventilated area, use appropriate PPE, prevent formation of dust and aerosols
Storage Requirements: Keep container tightly closed in cool, dry space, away from sunlight, strong acids, strong bases, oxidizing agents, and reducing agents
Incompatible Materials: Acids, alkalis, reducing and oxidizing agents, strong bases
Special Precautions: Store in original container with proper labeling, restrict access to trained personnel, keep segregated from food and feedstuff
Occupational Exposure Limit Values: No established OSHA, ACGIH, or NIOSH exposure limits; always implement good industrial hygiene standards
Engineering Controls: Work in chemical fume hood or with equivalent local exhaust ventilation
Personal Protective Equipment: Safety goggles, face shield, neoprene/nitrile gloves, lab coat or coveralls, chemical-resistant boots
Respiratory Protection: Use NIOSH/MSHA approved respirator if dust or vapor formation likely
Hygiene Measures: Wash hands and forearms after handling, remove contaminated clothing before leaving work area, do not eat or smoke during work
Appearance: White to off-white crystalline powder
Odor: Slight characteristic odor
Boiling Point: Decomposes before boiling
Melting Point: 130–132°C
Flash Point: Not flammable under normal conditions
Solubility in Water: 25 g/100 ml at 25°C
Partition Coefficient (log Kow): -0.64 (estimated)
Vapor Pressure: Negligible at 20°C
Relative Density: 2.0–2.3 at 20°C
pH (1% solution): 5–7
Evaporation Rate: Not applicable
Autoignition Temperature: Not self-igniting
Decomposition Temperature: Begins to decompose above 130°C
Stability: Stable under normal ambient and recommended conditions
Reactivity: Reacts violently with strong acids or bases, decomposes on heating, releases toxic gases
Hazardous Reactions: May react with reducing agents, can liberate nitrogen oxides and toxic bromine compounds
Hazardous Decomposition Products: Nitrogen oxides, hydrogen bromide, formaldehyde, carbon monoxide/dioxide
Conditions to Avoid: Heat, moisture, sunlight, sources of ignition, prolonged contact with incompatible materials
Likely Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rat): 305 mg/kg; LD50 (dermal, rabbit): 1600 mg/kg
Skin and Eye Irritation: Causes moderate skin irritation, severe eye damage
Long-Term Effects: Prolonged exposure linked to sensitization, possible respiratory irritation
Symptoms: Local redness, burns, abdominal pain, nausea, dermatitis with repeated contact
Carcinogenicity: No clear evidence in animal studies, not classified by IARC or NTP
Mutagenicity: Results mixed; some studies show DNA damage in vitro
Reproductive Toxicity: Insufficient human data, animal testing did not indicate significant risk
Acute Aquatic Toxicity: Highly toxic to aquatic organisms, EC50 (daphnia, 48h): 1.8 mg/L
Persistence and Degradability: Partial biodegradation; significant persistence in aquatic environments
Mobility in Soil: Moderate mobility, may leach to groundwater in significant spills
Bioaccumulative Potential: Low potential based on partition coefficient
Other Adverse Effects: May form breakdown products harmful to microorganisms
Product Disposal: Dispose of in accordance with local, regional, and national environmental regulations at licensed chemical waste facility
Packaging Disposal: Rinse empty containers thoroughly, puncture or crush, dispose along with controlled waste
Contaminated Waste: Collect in labeled, sealed containers, handle as hazardous chemical waste
Recommendation: Do not discharge to sewerage, waterways, or soil
UN Number: 3241
UN Proper Shipping Name: 2-Bromo-2-nitropropane-1,3-diol
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Environmental Hazards: Marine pollutant
Transport Labels: Toxic, environmentally hazardous
Special Precautions: Protect from moisture and sunlight during transport, follow all provision of ADR/RID, IMDG, IATA regulations
Inventory Listings: Listed on TSCA (US), EINECS (EU), DSL (Canada), AICS (Australia), ENCS (Japan)
Safety, Health, Environmental Regulations: Subject to workplace health regulation in many jurisdictions; regulated under REACH in Europe as SVHC candidate;
Restrictions: Use in cosmetics and skin products regulated in EU, limited in leave-on preparations
Label Requirements: Compliance with OSHA Hazard Communication, CLP (Europe), WHMIS (Canada)
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